OSCR

Ovarian central nervous system-type tumors: integrated neuropathological and methylation-based classification reveals site-related features.

Overview

Authors: Martin Raby1,2, Alexis Trécourt3,4, Euphrasie Servant1,5, Anne-Sophie Lebre5,6,7, Sabrina Croce8,9, Isabelle Treilleux10, Tatiana Franceschi10, Gerlinde Averous11, Catherine Genestie12, Margot Bucau13, Yassine Bouchoucha14, Dominique Berrebi2,15, Raphaël Saffroy16, Romain Appay17,18, Pierre-Alexandre Just19, Lauren Hasty1, Farah Sassi1, Alice Métais1,20, Pascale Varlet1,21, Mojgan Devouassoux-Shisheboran3,4, Arnault Tauziède-Espariat1
21 affiliations
  1. Department of Neuropathology, GHU Paris - Psychiatry and Neuroscience, Sainte-Anne Hospital, 1-Rue Cabanis, 75014 Paris, France
  2. Paris Cité University, Paris, France
  3. Multi-Site Department of Pathology, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France
  4. Faculty of Medicine Lyon-Sud-Charles Mérieux, UR 3738 CICLY, Claude Bernard University Lyon 1, Lyon, France
  5. Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, [Krebs team], Paris Cité University, 75014 Paris, France
  6. Faculty of medicine, University of Reims Champagne-Ardenne (URCA), Reims, France
  7. Department of Genetics, Reims University Hospital, Reims, France
  8. Department of Biopathology, Comprehensive Cancer Center, Bergonié Institute, Bordeaux, France
  9. INSERM Unit 1312, Bordeaux, France
  10. Department of Biopathology, Léon Bérard Center, Lyon, France
  11. Department of Pathology, CHRU, Strasbourg, France
  12. Biopathology Department, Unit 981, Gustave Roussy, Villejuif, France
  13. Pathology Department, Bichat Hospital, Paris, France
  14. SIREDO (Care, Innovation & Research in Childhood, Adolescent & Young-Adult Oncology) Oncology Center, Institut Curie, Paris, France
  15. Paediatric Pathology Department, Necker-Enfants Malades Hospital, Sorbonne Paris Cité, Paris, France
  16. Department of Biochemistry and Oncogenetic, Paul Brousse Hospital, 94804 Villejuif, France
  17. Neuropathology Department, AP-HM, Aix Marseille University, University Hospital Timone, 13005 Marseille, France
  18. Inst Neurophysiopathol, CNRS, INP, Aix-Marseille University, 13005 Marseille, France
  19. Department of Pathology, La Timone Hospital, Marseille, France
  20. Translational Research in Neuroscience Lab, Institut Imagine, INSERM U1163, Université Paris Cité, Paris, France
  21. Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, [IMA-Brain], Paris Cité University, 75014 Paris, France
Institutions: Université Paris Cité (France); Centre Hospitalier Sainte-Anne (France); Lyon 1 Université (France); Hospices Civils de Lyon (France); Hôpital Lyon Sud (France); Centre pour l'innovation en cancérologie de Lyon (France); Inserm (France); Institut de Psychiatrie et Neurosciences de Paris (France); Centre Hospitalier Universitaire de Reims (France); Université de Reims Champagne-Ardenne (France); Institut Bergonié (France); BoRdeaux Institute of onCology (France); Centre Léon Bérard (France); Hôpitaux Universitaires de Strasbourg (France); Institut Gustave Roussy (France); Fondation Gustave Roussy (France); Hôpital Bichat-Claude-Bernard (France); Institut Curie (France); Hôpital Necker-Enfants Malades (France); Sorbonne Paris Cité (France); Hôpital Paul-Brousse (France); Centre National de la Recherche Scientifique (France); Aix-Marseille Université (France); Assistance Publique Hôpitaux de Marseille (France); Institut de Neurophysiopathologie (France); Hôpital de la Timone (France); Institut des Maladies Génétiques Imagine (France)
Journal: Acta neuropathologica communications, volume 14, issue 1, article 139
Dates: received 22 February 2026; accepted 19 April 2026; published online 7 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s40478-026-02302-1 · PMID 42098819 · PMCID PMC13321577 · OpenAlex W7160540626
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), histology / microscopy (modality), human (organism), other condition (population)
Methods: Smoothing, state filtering, decompositions, Spectral & time-frequency
Keywords: PNET, Ovary, ETMR non C19MC-altered, Medulloblastoma SHH-activated, DNA-methylation
MeSH: Central Nervous System Neoplasms*, Ovarian Neoplasms*, Adolescent, Adult, Aged, Child, DNA Methylation, Female, Humans, Medulloblastoma, Middle Aged, Retrospective Studies, Young Adult (* major topic)
Topic: Glioma Diagnosis and Treatment (Genetics, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 27 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1186/s40478-026-02302-1.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 21 authors, 5 keywords, 13 MeSH terms, 26 references.

Cite

This paper

Raby, M., Trécourt, A., Servant, E., Lebre, A.-S., Croce, S., Treilleux, I., Franceschi, T., Averous, G., Genestie, C., Bucau, M., Bouchoucha, Y., Berrebi, D., Saffroy, R., Appay, R., Just, P.-A., Hasty, L., Sassi, F., Métais, A., Varlet, P., . . . Tauziède-Espariat, A. (2026). Ovarian central nervous system-type tumors: integrated neuropathological and methylation-based classification reveals site-related features. Acta neuropathologica communications, 14(1), 139. https://doi.org/10.1186/s40478-026-02302-1

BibTeX

@article{raby2026ovarian,
author = {Raby, Martin and Trécourt, Alexis and Servant, Euphrasie and Lebre, Anne-Sophie and Croce, Sabrina and Treilleux, Isabelle and Franceschi, Tatiana and Averous, Gerlinde and Genestie, Catherine and Bucau, Margot and Bouchoucha, Yassine and Berrebi, Dominique and Saffroy, Raphaël and Appay, Romain and Just, Pierre-Alexandre and Hasty, Lauren and Sassi, Farah and Métais, Alice and Varlet, Pascale and Devouassoux-Shisheboran, Mojgan and Tauziède-Espariat, Arnault},
title = {{Ovarian central nervous system-type tumors: integrated neuropathological and methylation-based classification reveals site-related features}},
journal = {Acta neuropathologica communications},
year = {2026},
month = may,
volume = {14},
number = {1},
pages = {139},
publisher = {BMC},
issn = {2051-5960},
doi = {10.1186/s40478-026-02302-1},
url = {https://doi.org/10.1186/s40478-026-02302-1},
pmid = {42098819},
pmcid = {PMC13321577}
}

RIS

TY - JOUR
AU - Raby, Martin
AU - Trécourt, Alexis
AU - Servant, Euphrasie
AU - Lebre, Anne-Sophie
AU - Croce, Sabrina
AU - Treilleux, Isabelle
AU - Franceschi, Tatiana
AU - Averous, Gerlinde
AU - Genestie, Catherine
AU - Bucau, Margot
AU - Bouchoucha, Yassine
AU - Berrebi, Dominique
AU - Saffroy, Raphaël
AU - Appay, Romain
AU - Just, Pierre-Alexandre
AU - Hasty, Lauren
AU - Sassi, Farah
AU - Métais, Alice
AU - Varlet, Pascale
AU - Devouassoux-Shisheboran, Mojgan
AU - Tauziède-Espariat, Arnault
TI - Ovarian central nervous system-type tumors: integrated neuropathological and methylation-based classification reveals site-related features
T2 - Acta neuropathologica communications
J2 - Acta Neuropathol Commun
PY - 2026
DA - 2026/05/07
VL - 14
IS - 1
SP - 139
SN - 2051-5960
PB - BMC
DO - 10.1186/s40478-026-02302-1
UR - https://doi.org/10.1186/s40478-026-02302-1
LA - en
ER -

CSL-JSON

{
"id": "10.1186/s40478-026-02302-1",
"type": "article-journal",
"title": "Ovarian central nervous system-type tumors: integrated neuropathological and methylation-based classification reveals site-related features",
"container-title": "Acta neuropathologica communications",
"author": [
{
"family": "Raby",
"given": "Martin"
},
{
"family": "Trécourt",
"given": "Alexis"
},
{
"family": "Servant",
"given": "Euphrasie"
},
{
"family": "Lebre",
"given": "Anne-Sophie"
},
{
"family": "Croce",
"given": "Sabrina"
},
{
"family": "Treilleux",
"given": "Isabelle"
},
{
"family": "Franceschi",
"given": "Tatiana"
},
{
"family": "Averous",
"given": "Gerlinde"
},
{
"family": "Genestie",
"given": "Catherine"
},
{
"family": "Bucau",
"given": "Margot"
},
{
"family": "Bouchoucha",
"given": "Yassine"
},
{
"family": "Berrebi",
"given": "Dominique"
},
{
"family": "Saffroy",
"given": "Raphaël"
},
{
"family": "Appay",
"given": "Romain"
},
{
"family": "Just",
"given": "Pierre-Alexandre"
},
{
"family": "Hasty",
"given": "Lauren"
},
{
"family": "Sassi",
"given": "Farah"
},
{
"family": "Métais",
"given": "Alice"
},
{
"family": "Varlet",
"given": "Pascale"
},
{
"family": "Devouassoux-Shisheboran",
"given": "Mojgan"
},
{
"family": "Tauziède-Espariat",
"given": "Arnault"
}
],
"container-title-short": "Acta Neuropathol Commun",
"volume": "14",
"issue": "1",
"page": "139",
"DOI": "10.1186/s40478-026-02302-1",
"PMID": "42098819",
"PMCID": "PMC13321577",
"ISSN": "2051-5960",
"publisher": "BMC",
"URL": "https://doi.org/10.1186/s40478-026-02302-1",
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
7
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1111/bpa.70092
Molecular and clinical features of a Japanese medulloblastoma cohort: Subgroup-specific prognostic stratification using economical/accessible diagnostic methods.
Journal: Brain pathology (Zurich, Switzerland)
In common: genetics / omics, other condition, 5 references
[2] doi:10.1038/s41586-026-10631-3 [code]
A prognostic human brain network for diffuse midline glioma.
Journal: Nature
In common: other condition, 3 references
[3] doi:10.1038/s41586-026-10214-2 [code]
Multidimensional profiling of heterogeneity in supratentorial ependymomas.
Journal: Nature
In common: genetics / omics, other condition, 2 references
[4] doi:10.1186/s40478-026-02382-z
Methylation profiling and alternative classification approaches in a glioma-enriched FFPE stereotaxic biopsy cohort.
Journal: Acta neuropathologica communications
In common: histology / microscopy, genetics / omics, other condition, 2 references
[5] doi:10.1186/s40478-026-02269-z
Histological grade 2 and non-contrast-enhancing phenotype provide prognostic information complementary to DNA methylation classification in TERTp-mutant molecular glioblastomas.
Journal: Acta neuropathologica communications
In common: histology / microscopy, genetics / omics, other condition, 2 references
[6] doi:10.1038/s41467-026-77170-3 [code]
DNA methylation profiling identifies long-range epigenetic silencing of clustered protocadherins as a key determinant of meningioma progression.
Journal: Nature communications
In common: genetics / omics, other condition, 2 references
[7] doi:10.1016/j.xcrm.2026.102682 [code]
TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas.
Journal: Cell reports. Medicine
In common: genetics / omics, other condition, 2 references
[8] doi:10.1186/s40478-026-02402-y
Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma.
Journal: Acta neuropathologica communications
In common: genetics / omics, other condition, 2 references
[9] doi:10.1038/s43018-026-01199-y
IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial.
Journal: Nature cancer
In common: other condition, 2 references
[10] doi:10.1186/s40170-026-00432-7
In vivo characterization of the redox balance in IDH-wildtype glioblastomas: a J-difference edited MEGA-sLASER MRS study at 3T.
Journal: Cancer & metabolism
In common: other condition, 2 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.