NGF promotes, in an autocrine-paracrine manner, metabolic and anti-inflammatory pathways in human and mouse adipocytes.
Overview
- Laboratory of Clinical Chemistry, Department of Laboratory Medicine, School of Medicine, University of Crete, Heraklion 71003, Crete, Greece
- Department of General Surgery, University Hospital of Heraklion, Heraklion 71110, Crete, Greece
- Laboratory of Pharmacology, Department of Basic Sciences, School of Medicine, University of Crete, Heraklion 71003, Crete, Greece
- Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas (FORTH), Heraklion 70013, Crete, Greece
Abstract
Context: Nerve growth factor (NGF) affects the development and survival of sympathetic neurons. NGF is also found in non-neural cell lineages that are implicated in immune-endocrine interactions associated with metabolic diseases. Although NGF is expressed in white adipose tissue (WAT), little is known about the regulation of its expression and role in adipocytes.
Objective: To determine whether NGF and its receptors are expressed in human adipocytes and demonstrate their role in adipocyte metabolic and inflammatory phenotypes.
Methods: The expression of NGF and its receptors, tropomyosin-related kinase A (TrkA) and pan-neurotrophin receptor (p75NTR), and their effects on metabolic and inflammatory responses were examined in freshly isolated adipocytes from human abdominal WAT and mouse 3T3L1 cells.
Results: TrkA and p75NTR were expressed in both human and mouse adipocytes and pre-adipocytes. NGF was secreted by human white adipocytes and their exogenous exposure to NGF increased mitochondrial mass and activity, peroxisome proliferator-activated receptor gamma, CCAAT/
Conclusion: Our data suggest that NGF is produced locally within the adipose tissue where it upregulates mitochondrial function while it suppresses the pro-inflammatory phenotype of human and mouse adipocytes.
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Zenodo 17447920
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Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 4 keywords, 15 MeSH terms, 1 funder, 46 references, 11 RRIDs.
Cite
This paper
Deiktakis, M., Athanasakis, E., Charalampopoulos, I., Gravanis, A., Tsatsanis, C., Venihaki, M., Margioris, A. N., & Dermitzaki, E. (2026). NGF promotes, in an autocrine-paracrine manner, metabolic and anti-inflammatory pathways in human and mouse adipocytes. The Journal of clinical endocrinology and metabolism, 111(7), e1892-e1907. https://
BibTeX
@article{deiktakis2026ng
author = {Deiktakis, Michail and Athanasakis, Elias and Charalampopoulos, Ioannis and Gravanis, Achille and Tsatsanis, Christos and Venihaki, Maria and Margioris, Andrew N and Dermitzaki, Eirini},
title = {{NGF promotes, in an autocrine-paracrine manner, metabolic and anti-inflammatory pathways in human and mouse adipocytes}},
journal = {The Journal of clinical endocrinology and metabolism},
year = {2026},
month = jun,
volume = {111},
number = {7},
pages = {e1892--e1907},
publisher = {The Endocrine Society},
issn = {0021-972X},
doi = {10.1210/
url = {https://
pmid = {41556140},
pmcid = {PMC13502198}
}
RIS
TY - JOUR
AU - Deiktakis, Michail
AU - Athanasakis, Elias
AU - Charalampopoulos, Ioannis
AU - Gravanis, Achille
AU - Tsatsanis, Christos
AU - Venihaki, Maria
AU - Margioris, Andrew N
AU - Dermitzaki, Eirini
TI - NGF promotes, in an autocrine-paracrine manner, metabolic and anti-inflammatory pathways in human and mouse adipocytes
T2 - The Journal of clinical endocrinology and metabolism
J2 - J Clin Endocrinol Metab
PY - 2026
DA - 2026/
VL - 111
IS - 7
SP - e1892
EP - e1907
SN - 0021-972X
PB - The Endocrine Society
DO - 10.1210/
UR - https://
LA - en
ER -
CSL-JSON
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