OSCR

Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females.

Overview

Authors: Marina S Puffer1, Jason Yang1, Lourdes A Esparza1, Lillian Rose1, Viet Duong1, Sally Radovick2, Alexander S Kauffman1
ORCID iDs: Lourdes A Esparza, Alexander S Kauffman
  1. Department of OBGYN and Reproductive Sciences, University of California San Diego, La Jolla, CA 92093, USA
  2. Department of Pediatrics, University of Arizona College of Medicine, Phoenix, AZ 85004, USA
Institutions: University of California San Diego (United States); University of Arizona College of Medicine- Phoenix (United States)
Journal: Endocrinology, volume 167, issue 6, article bqag049
Dates: received 22 July 2025; accepted 13 April 2026; published online 30 April 2026; in print May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1210/endocr/bqag049 · PMID 42057695 · PMCID PMC13148160 · OpenAlex W7158924709
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), clinical / translational (subfield)
Methods: Statistics
Keywords: LH surge, kisspeptin, Kiss1, GnRH, fertility, ovulation
MeSH: Estradiol*, Fertility*, Kisspeptins*, Luteinizing Hormone*, Preoptic Area*, Animals, Estrous Cycle, Female, Hypothalamic-Pituitary-Gonadal Axis, Mice, Mice, Knockout, Mice, Transgenic, Neurons, Third Ventricle (* major topic)
Topic: Hypothalamic control of reproductive hormones (Reproductive Medicine, Medicine), according to OpenAlex
Funding: NIH HHS (R01 HD109477, R01 HD111650)
Citations: not cited yet (Europe PMC); 64 references in the paper
Research resources: RRID:AB_2665513, RRID:AB_2665514, detection polyclonal antibody RRID:AB_2665533, THCRE female mice RRID:IMSR_JAX:008601

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1210/endocr/bqag049.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 6 keywords, 14 MeSH terms, 1 funder, 64 references, 4 RRIDs.

Cite

This paper

Puffer, M. S., Yang, J., Esparza, L. A., Rose, L., Duong, V., Radovick, S., & Kauffman, A. S. (2026). Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females. Endocrinology, 167(6), bqag049. https://doi.org/10.1210/endocr/bqag049

BibTeX

@article{puffer2026kisspeptin,
author = {Puffer, Marina S and Yang, Jason and Esparza, Lourdes A and Rose, Lillian and Duong, Viet and Radovick, Sally and Kauffman, Alexander S},
title = {{Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females}},
journal = {Endocrinology},
year = {2026},
month = may,
volume = {167},
number = {6},
pages = {bqag049},
publisher = {The Endocrine Society},
issn = {0013-7227},
doi = {10.1210/endocr/bqag049},
url = {https://doi.org/10.1210/endocr/bqag049},
pmid = {42057695},
pmcid = {PMC13148160}
}

RIS

TY - JOUR
AU - Puffer, Marina S
AU - Yang, Jason
AU - Esparza, Lourdes A
AU - Rose, Lillian
AU - Duong, Viet
AU - Radovick, Sally
AU - Kauffman, Alexander S
TI - Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females
T2 - Endocrinology
J2 - Endocrinology
PY - 2026
DA - 2026/05/01
VL - 167
IS - 6
SP - bqag049
SN - 0013-7227
PB - The Endocrine Society
DO - 10.1210/endocr/bqag049
UR - https://doi.org/10.1210/endocr/bqag049
LA - en
ER -

CSL-JSON

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"title": "Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females",
"container-title": "Endocrinology",
"author": [
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"family": "Puffer",
"given": "Marina S"
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{
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],
"container-title-short": "Endocrinology",
"volume": "167",
"issue": "6",
"page": "bqag049",
"DOI": "10.1210/endocr/bqag049",
"PMID": "42057695",
"PMCID": "PMC13148160",
"ISSN": "0013-7227",
"publisher": "The Endocrine Society",
"URL": "https://doi.org/10.1210/endocr/bqag049",
"language": "en",
"issued": {
"date-parts": [
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]
}
}

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