Inward rectifier potassium channels interact with calcium channels to promote robust and physiological bistability.

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Paper

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The authors' code

Julia · 30 lines · 841 B · MIT

include("gates.jl")
function INa(gNa,mNa,hNa,V,eNa)
INa = gNa*mNa^3*hNa*(V-eNa) # [µA/cm^2]
return INa
end
function IKDR(gKDR,mKDR,V,eK)
IKDR = gKDR*mKDR^4*(V-eK) # [µA/cm^2]
return IKDR
end
function ICaLf(pCaLf,mCaLf,hCaLf,V,Ca,Ca_o)
ICaLf = pCaLf*mCaLf^2*hCaLf*ghk_LeFranc(V, Ca, Ca_o) *1000 # [µA/cm^2] instead of [mA/cm^2]
return ICaLf
end
function ICaLs(pCaLs,mCaLs,hCaLs,V,Ca,Ca_o)
ICaLs = pCaLs*mCaLs*hCaLs*ghk_LeFranc(V, Ca, Ca_o) *1000 # [µA/cm^2] instead of [mA/cm^2]
return ICaLs
end
function IKir(gKir,mKir,V,eK)
IKir = gKir*mKir*(V-eK) # [µA/cm^2]
return IKir
end
function IKM(gKM,mKM,V,eK)
IKM = gKM*mKM*(V-eK) # [µA/cm^2]
return IKM
end
function Ileak(gleak,V,eleak)
Ileak = gleak*(V-eleak) # [µA/cm^2]
return Ileak
end

currents.jl at commit a4cb390, under MIT · at the source

Overview

Authors: Anaëlle De Worm¹, Guillaume Drion¹, Pierre Sacré¹

ORCID iDs: Anaëlle De Worm, Pierre Sacré

Department of Electrical Engineering and Computer Science, University of Liège, Liège, Belgium

Institutions: University of Liège (Belgium)

Journal: PLoS computational biology, volume 22, issue 7, article e1014549

Dates: received 23 May 2025; accepted 8 July 2026; published online 28 July 2026

Type: Research article · Language: English

License: CC BY

Identifiers: DOI 10.1371/journal.pcbi.1014549 · PMID 42520078 · PMCID PMC13441080 · OpenAlex W7171485400

Open access: gold, a free copy (OpenAlex)

Status: code verified

Categories: cellular / molecular (subfield)

MeSH: Calcium Channels*, Models, Neurological*, Potassium Channels, Inwardly Rectifying*, Action Potentials, Animals, Computational Biology (* major topic)

Topic: Neural dynamics and brain function (Cognitive Neuroscience, Neuroscience), according to OpenAlex

Funding: Waalse Gewest; Belgian Federal Science Policy Office (NEMODEI2)

Citations: not cited yet (Europe PMC); 42 references in the paper

Abstract

Projection neurons in the dorsal horn relay nociceptive input to supraspinal centers. During central sensitization, a subset of them switches from tonic firing to plateau potentials with sustained afterdischarges, a change that requires intrinsic bistability between a resting and a spiking state. Voltage-gated L-type calcium (CaL) channels can produce bistability, but reach physiological resting states only when paired with voltage-gated potassium channels, most of which simultaneously shrink the bistability window. How robust, physiological bistability arises has therefore remained unclear. Using a minimal conductance-based model, we show that inward rectifier potassium (Kir) channels enlarge the bistability window when combined with CaL channels, while M-type potassium (KM) channels slightly reduce it. Within the parameter region where bistability is both robust and physiological, both channel types can sustain bistability, but the CaL + Kir combination produces a substantially larger window and is more robust to noise and intrinsic variability. This window-enlarging effect traces to a shape feature of the outward Kir steady-state current: like the CaL current, it has a region of negative differential conductance around the spike threshold, a feature absent from KM and from most other voltage-gated potassium currents. Bifurcation analysis further shows that the two pairs support qualitatively distinct excitability: plateau-generating bistability for CaL + Kir and resonator-like dynamics for CaL + KM. These conclusions hold in a two-compartment model of deep projection neurons with realistic ion channel complements, and identify the CaL + Kir pair as a candidate intrinsic mechanism for central sensitization.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repository

Its files are read in the Code ↔ Paper reader above.

anadew2/cal-kir-bistability

License: MIT

State: the link answers, verified on 27 September 2026

Evidence: files inventoried

Commit: a4cb390e5a4593adef0c85c91b7069c717aafe9c, 29 April 2026

Languages: Julia (163), Shell (56)

Size: 860 files, 219 scripts

Software Heritage: not archived

Found in: the text, “Software”

Holds: README, license file, environment (.vscode/env/Manifest.toml, .vscode/env/Project.toml), tests

Not found: CITATION.cff, continuous integration, documentation

Tools: Plots.jl (81 files), DifferentialEquations.jl (60 files), DataFrames.jl (6 files), Distributions.jl (1 file)

Availability: 1 check, the latest on 27 September 2026: the link answers

27 September 2026: the link answers

221 files

currents.jl, Julia, 30 lines
fixedpoints.jl, Julia, 551 lines
gates.jl, Julia, 225 lines
membrane.jl, Julia, 118 lines
sim.jl, Julia, 74 lines
solver_fun.jl, Julia, 12 lines
test_gates.jl, Julia, 15 lines
tests/LeFranc-multicomp-jl/compartment.jl, Julia, 221 lines
tests/LeFranc-multicomp-jl/compartment_test.jl, Julia, 83 lines
tests/LeFranc-multicomp-jl/currents.jl, Julia, 75 lines
tests/LeFranc-multicomp-jl/dI_grad/comp_dI_outputs.jl, Julia, 114 lines
tests/LeFranc-multicomp-jl/dI_grad/data_loader.jl, Julia, 73 lines
tests/LeFranc-multicomp-jl/dI_grad/data_loader_ext.jl, Julia, 73 lines
tests/LeFranc-multicomp-jl/dI_grad/fct_dI_grad.jl, Julia, 327 lines
tests/LeFranc-multicomp-jl/dI_grad/fct_local_postpro_output.jl, Julia, 340 lines
tests/LeFranc-multicomp-jl/dI_grad/jld_hdle_dI_grad.jl, Julia, 46 lines
tests/LeFranc-multicomp-jl/dI_grad/job.sh, Shell, 10 lines
tests/LeFranc-multicomp-jl/dI_grad/local_postpro_output.jl, Julia, 86 lines
tests/LeFranc-multicomp-jl/dI_grad/script_dI_grad_Kir_s.jl, Julia, 49 lines
tests/LeFranc-multicomp-jl/dI_grad/test.sh, Shell, 21 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/data_loader.jl, Julia, 73 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/data_loader_ext.jl, Julia, 73 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/fct_dI_grad.jl, Julia, 327 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/fct_local_postpro_output.jl, Julia, 340 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/gates_compart_KM_instead_Kir.jl, Julia, 204 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/jld_hdle_dI_grad.jl, Julia, 46 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/job.sh, Shell, 10 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/local_postpro_output_ext.jl, Julia, 79 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/local_test.jl, Julia, 57 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/script_dI_grad_Kir_s.jl, Julia, 49 lines
tests/LeFranc-multicomp-jl/dI_grad_KM_instead_Kir/test.sh, Shell, 21 lines
tests/LeFranc-multicomp-jl/fI_curve/bif-km.jl, Julia, 189 lines
tests/LeFranc-multicomp-jl/fI_curve/bif.jl, Julia, 189 lines
tests/LeFranc-multicomp-jl/fI_curve/compartment_simulation-km.jl, Julia, 87 lines
tests/LeFranc-multicomp-jl/fI_curve/compartment_simulation.jl, Julia, 76 lines
tests/LeFranc-multicomp-jl/fI_curve/data_loader.jl, Julia, 86 lines
tests/LeFranc-multicomp-jl/fI_curve/data_loader_km.jl, Julia, 77 lines
tests/LeFranc-multicomp-jl/fI_curve/fct_fI_curve.jl, Julia, 167 lines
tests/LeFranc-multicomp-jl/fI_curve/jld_hdle_fI.jl, Julia, 92 lines
tests/LeFranc-multicomp-jl/fI_curve/job.sh, Shell, 10 lines
tests/LeFranc-multicomp-jl/fI_curve/local_postpro_outputs_batch-KM.jl, Julia, 154 lines
tests/LeFranc-multicomp-jl/fI_curve/local_postpro_outputs_batch.jl, Julia, 154 lines
tests/LeFranc-multicomp-jl/fI_curve/script_fI_curve.jl, Julia, 65 lines
tests/LeFranc-multicomp-jl/fI_curve/test.sh, Shell, 21 lines
tests/LeFranc-multicomp-jl/figures/fig-5-km.jl, Julia, 302 lines
tests/LeFranc-multicomp-jl/figures/fig-5.jl, Julia, 303 lines
tests/LeFranc-multicomp-jl/fixedpoints.jl, Julia, 623 lines
tests/LeFranc-multicomp-jl/gates_compart.jl, Julia, 188 lines
tests/LeFranc-multicomp-jl/solver_fun.jl, Julia, 12 lines
tests/V0_basin/data_loader_larger_range_kir.jl, Julia, 127 lines
tests/V0_basin/data_loader_larger_range_km.jl, Julia, 128 lines
tests/V0_basin/job_kir.sh, Shell, 10 lines
tests/V0_basin/job_km.sh, Shell, 10 lines
tests/V0_basin/local_postpro_outputs.jl, Julia, 153 lines
tests/V0_basin/script_V0_basin_kir.jl, Julia, 196 lines
tests/V0_basin/script_V0_basin_km.jl, Julia, 196 lines
tests/V0_basin/test_kir.sh, Shell, 13 lines
tests/V0_basin/test_km.sh, Shell, 13 lines
tests/dI_grad/data_loader.jl, Julia, 57 lines
tests/dI_grad/data_loader_larger_range.jl, Julia, 73 lines
tests/dI_grad/job.sh, Shell, 13 lines
tests/dI_grad/job_km.sh, Shell, 13 lines
tests/dI_grad/local_postpro_output.jl, Julia, 316 lines
tests/dI_grad/local_postpro_output_larger_range.jl, Julia, 189 lines
tests/dI_grad/local_postpro_output_pCaLf_e-4.jl, Julia, 151 lines
tests/dI_grad/local_postpro_output_pCaLf_e-5.jl, Julia, 151 lines
tests/dI_grad/script_dI_grad.jl, Julia, 436 lines
tests/dI_grad/script_dI_grad_km.jl, Julia, 433 lines
tests/dI_grad/test.sh, Shell, 20 lines
tests/dI_grad/test_km.sh, Shell, 20 lines
tests/dI_grad_altgt/data_loader.jl, Julia, 51 lines
tests/dI_grad_altgt/data_loader_larger_range.jl, Julia, 73 lines
tests/dI_grad_altgt/job.sh, Shell, 10 lines
tests/dI_grad_altgt/local_postpro_output.jl, Julia, 264 lines
tests/dI_grad_altgt/script_dI_grad.jl, Julia, 443 lines
tests/dI_grad_altgt/test.sh, Shell, 27 lines
tests/dI_grad_m2/currents_m2.jl, Julia, 30 lines
tests/dI_grad_m2/data_loader_larger_range_m2.jl, Julia, 73 lines
tests/dI_grad_m2/fixedpoints_CaLf_replaced_by_CaLs.jl, Julia, 551 lines
tests/dI_grad_m2/gates_CaLf_replaced_by_CaLs.jl, Julia, 229 lines
tests/dI_grad_m2/job.sh, Shell, 13 lines
tests/dI_grad_m2/job_km.sh, Shell, 13 lines
tests/dI_grad_m2/local_postpro_output_m2.jl, Julia, 172 lines
tests/dI_grad_m2/membrane_CaLf_replaced_by_CaLs.jl, Julia, 118 lines
tests/dI_grad_m2/script_dI_grad_f_repl_by_s.jl, Julia, 434 lines
tests/dI_grad_m2/script_dI_grad_f_repl_by_s_km.jl, Julia, 434 lines
tests/dI_grad_m2/test.sh, Shell, 20 lines
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tests/dI_grad_no_ghk/currents_no_ghk.jl, Julia, 30 lines
tests/dI_grad_no_ghk/data_loader_larger_range_no_ghk.jl, Julia, 73 lines
tests/dI_grad_no_ghk/fixedpoints_no_ghk.jl, Julia, 563 lines
tests/dI_grad_no_ghk/job.sh, Shell, 13 lines
tests/dI_grad_no_ghk/job_km.sh, Shell, 13 lines
tests/dI_grad_no_ghk/local_postpro_output_no_ghk.jl, Julia, 157 lines
tests/dI_grad_no_ghk/membrane_no_ghk.jl, Julia, 118 lines
tests/dI_grad_no_ghk/script_dI_grad_km_no_ghk.jl, Julia, 420 lines
tests/dI_grad_no_ghk/script_dI_grad_no_ghk.jl, Julia, 422 lines
tests/dI_grad_no_ghk/sim_no_ghk.jl, Julia, 64 lines
tests/dI_grad_no_ghk/test.sh, Shell, 20 lines
tests/dI_grad_no_ghk/test_km.sh, Shell, 20 lines
tests/dI_grad_no_ghk_m2/currents_no_ghk_m2.jl, Julia, 30 lines
tests/dI_grad_no_ghk_m2/data_loader_larger_range_no_ghk_m2.jl, Julia, 73 lines
tests/dI_grad_no_ghk_m2/fixedpoints_no_ghk_m2.jl, Julia, 562 lines
tests/dI_grad_no_ghk_m2/gates_CaLf_replaced_by_CaLs.jl, Julia, 229 lines
tests/dI_grad_no_ghk_m2/job.sh, Shell, 13 lines
tests/dI_grad_no_ghk_m2/job_km.sh, Shell, 13 lines
tests/dI_grad_no_ghk_m2/local_postpro_output_no_ghk_m2.jl, Julia, 158 lines
tests/dI_grad_no_ghk_m2/membrane_no_ghk_m2.jl, Julia, 119 lines
tests/dI_grad_no_ghk_m2/script_dI_grad_km_no_ghk_m2.jl, Julia, 432 lines
tests/dI_grad_no_ghk_m2/script_dI_grad_no_ghk_m2.jl, Julia, 434 lines
tests/dI_grad_no_ghk_m2/test.sh, Shell, 20 lines
tests/dI_grad_no_ghk_m2/test_km.sh, Shell, 20 lines
tests/dI_grad_other_km/IKv72_comparison.jl, Julia, 63 lines
tests/dI_grad_other_km/currents_other_km.jl, Julia, 31 lines
tests/dI_grad_other_km/data_loader.jl, Julia, 56 lines
tests/dI_grad_other_km/data_loader_larger_range.jl, Julia, 56 lines
tests/dI_grad_other_km/fixedpoints_other_km.jl, Julia, 552 lines
tests/dI_grad_other_km/gates_other_km.jl, Julia, 230 lines
tests/dI_grad_other_km/job_km.sh, Shell, 10 lines
tests/dI_grad_other_km/local_postpro_output_other_km.jl, Julia, 121 lines
tests/dI_grad_other_km/membrane_other_km.jl, Julia, 118 lines
tests/dI_grad_other_km/script_dI_grad_km.jl, Julia, 433 lines
tests/dI_grad_other_km/test_km.sh, Shell, 20 lines
tests/dI_inw/currents_inw.jl, Julia, 30 lines
tests/dI_inw/data_loader_inw.jl, Julia, 41 lines
tests/dI_inw/fixedpoints_inw.jl, Julia, 551 lines
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tests/dI_inw/membrane_inw.jl, Julia, 118 lines
tests/dI_inw/script_dI_inw_kir.jl, Julia, 432 lines
tests/dI_inw/script_dI_inw_km.jl, Julia, 432 lines
tests/dI_inw/test.sh, Shell, 13 lines
tests/dI_inw/test_km.sh, Shell, 13 lines
tests/dI_noise/asc_std_kir_I1.jl, Julia, 195 lines
tests/dI_noise/asc_std_kir_Ihalf.jl, Julia, 199 lines
tests/dI_noise/asc_std_km_I1.jl, Julia, 193 lines
tests/dI_noise/asc_std_km_Ihalf.jl, Julia, 199 lines
tests/dI_noise/data_loader_larger_range_kir.jl, Julia, 136 lines
tests/dI_noise/data_loader_larger_range_kir_I1.jl, Julia, 136 lines
tests/dI_noise/data_loader_larger_range_km.jl, Julia, 136 lines
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tests/dI_noise/local_postpro_outputs.jl, Julia, 279 lines
tests/dI_noise/local_postpro_outputs_I1.jl, Julia, 252 lines
tests/dI_noise/locall_postrpro_asc_std.jl, Julia, 125 lines
tests/dI_noise/script_dI_noise_cyc_kir.jl, Julia, 366 lines
tests/dI_noise/script_dI_noise_cyc_km.jl, Julia, 365 lines
tests/dI_noise/script_dI_noise_kir.jl, Julia, 364 lines
tests/dI_noise/script_dI_noise_km.jl, Julia, 364 lines
tests/dI_noise/test_cyc.sh, Shell, 19 lines
tests/dI_noise/test_km_cyc.sh, Shell, 19 lines
tests/dI_noise/test_km_st.sh, Shell, 19 lines
tests/dI_noise/test_st.sh, Shell, 19 lines
tests/dI_outw/currents_outw.jl, Julia, 30 lines
tests/dI_outw/data_loader_outw.jl, Julia, 41 lines
tests/dI_outw/fixedpoints_outw.jl, Julia, 551 lines
tests/dI_outw/gates_outw.jl, Julia, 233 lines
tests/dI_outw/job.sh, Shell, 13 lines
tests/dI_outw/job_km.sh, Shell, 13 lines
tests/dI_outw/local_postpro_outputs.jl, Julia, 169 lines
tests/dI_outw/membrane_outw.jl, Julia, 118 lines
tests/dI_outw/script_dI_outw_kir.jl, Julia, 432 lines
tests/dI_outw/script_dI_outw_km.jl, Julia, 432 lines
tests/dI_outw/test.sh, Shell, 13 lines
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tests/dI_var_mc/data_loader.jl, Julia, 99 lines
tests/dI_var_mc/job_kir.sh, Shell, 13 lines
tests/dI_var_mc/job_km.sh, Shell, 13 lines
tests/dI_var_mc/local_postpro_outputs.jl, Julia, 178 lines
tests/dI_var_mc/script_dI_var_mc_kir.jl, Julia, 435 lines
tests/dI_var_mc/script_dI_var_mc_km.jl, Julia, 435 lines
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tests/dI_var_mc/test_km.sh, Shell, 13 lines
tests/fI_curve/bif_kir.jl, Julia, 112 lines
tests/fI_curve/bif_km.jl, Julia, 117 lines
tests/fI_curve/data_loader.jl, Julia, 92 lines
tests/fI_curve/job_kir.sh, Shell, 11 lines
tests/fI_curve/job_km.sh, Shell, 11 lines
tests/fI_curve/local_postpro_outputs_batch.jl, Julia, 223 lines
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tests/fI_curve/script_fI_curve_km.jl, Julia, 234 lines
tests/fI_curve/test_kir.sh, Shell, 26 lines
tests/fI_curve/test_km.sh, Shell, 26 lines
tests/fI_curve_altgt/bif.jl, Julia, 128 lines
tests/fI_curve_altgt/data_loader.jl, Julia, 88 lines
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tests/fI_curve_altgt/local_postpro_outputs_batch.jl, Julia, 171 lines
tests/fI_curve_altgt/script_fI_curve.jl, Julia, 239 lines
tests/fI_curve_altgt/test.sh, Shell, 33 lines
tests/figures/fig-1.jl, Julia, 169 lines
tests/figures/fig-10-11.jl, Julia, 241 lines
tests/figures/fig-2.jl, Julia, 220 lines
tests/figures/fig-3.jl, Julia, 241 lines
tests/figures/fig-4.jl, Julia, 328 lines
tests/figures/fig-6-I1.jl, Julia, 121 lines
tests/figures/fig-6.jl, Julia, 133 lines
tests/figures/fig-6B.jl, Julia, 14 lines
tests/figures/fig-7.jl, Julia, 155 lines
tests/figures/fig-8.jl, Julia, 87 lines
tests/figures/fig-9.jl, Julia, 181 lines
tests/figures/fig-A1-ICaLs_eq.jl, Julia, 156 lines
tests/figures/fig-A1-fI_vI_hh.jl, Julia, 153 lines
tests/figures/fig-A2-ICaLs_eq.jl, Julia, 156 lines
tests/figures/fig-A2-pCaLf_increased.jl, Julia, 102 lines
tests/figures/fig-A3-other_mKM.jl, Julia, 28 lines
tests/figures/fig-A4-pCaLf_increased.jl, Julia, 102 lines
tests/figures/fig-A5-other_mKM.jl, Julia, 28 lines
tests/sim_pulse_step/sim_CaLs.jl, Julia, 94 lines
tests/sim_pulse_step/sim_KM.jl, Julia, 88 lines
tests/sim_pulse_step/sim_Kir.jl, Julia, 85 lines
tests/sim_pulse_step/sim_inward.jl, Julia, 98 lines
tests/sim_pulse_step/sim_outward.jl, Julia, 104 lines
tests/sim_pulse_step/sim_switch.jl, Julia, 266 lines
tests/sim_pulse_step/steady_state_currents.jl, Julia, 44 lines
LICENSE, License, 21 lines
README.md, Text, 1 line

At the source: github.com/anadew2/cal-kir-bistability

The paper's code and data availability statement is in the Data section.

Tracing map

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What the map holds:

1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
219 scripts, each with its path and the digest of its content;
no match between paragraphs and code yet;
neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data Availability

All data and code used for running experiments and plotting are available at https://github.com/anadew2/cal-kir-bistability/tree/main.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

Funding: added Waalse Gewest; Belgian Federal Science Policy Office: NEMODEI2

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 6 MeSH terms, 41 references.

Cite

This paper

De Worm, A., Drion, G., & Sacré, P. (2026). Inward rectifier potassium channels interact with calcium channels to promote robust and physiological bistability. PLoS computational biology, 22(7), e1014549. https://doi.org/10.1371/journal.pcbi.1014549

BibTeX

@article{deworm2026inward, author = {De Worm, Anaëlle and Drion, Guillaume and Sacré, Pierre}, title = {{Inward rectifier potassium channels interact with calcium channels to promote robust and physiological bistability}}, journal = {PLoS computational biology}, year = {2026}, month = jul, volume = {22}, number = {7}, pages = {e1014549}, publisher = {PLOS}, issn = {1553-734X}, doi = {10.1371/journal.pcbi.1014549}, url = {https://doi.org/10.1371/journal.pcbi.1014549}, pmid = {42520078}, pmcid = {PMC13441080} }

RIS

TY - JOUR AU - De Worm, Anaëlle AU - Drion, Guillaume AU - Sacré, Pierre TI - Inward rectifier potassium channels interact with calcium channels to promote robust and physiological bistability T2 - PLoS computational biology J2 - PLoS Comput Biol PY - 2026 DA - 2026/07/28 VL - 22 IS - 7 SP - e1014549 SN - 1553-734X PB - PLOS DO - 10.1371/journal.pcbi.1014549 UR - https://doi.org/10.1371/journal.pcbi.1014549 LA - en ER -

CSL-JSON

{ "id": "10.1371/journal.pcbi.1014549", "type": "article-journal", "title": "Inward rectifier potassium channels interact with calcium channels to promote robust and physiological bistability", "container-title": "PLoS computational biology", "author": [ { "family": "De Worm", "given": "Anaëlle" }, { "family": "Drion", "given": "Guillaume" }, { "family": "Sacré", "given": "Pierre" } ], "container-title-short": "PLoS Comput Biol", "volume": "22", "issue": "7", "page": "e1014549", "DOI": "10.1371/journal.pcbi.1014549", "PMID": "42520078", "PMCID": "PMC13441080", "ISSN": "1553-734X", "publisher": "PLOS", "URL": "https://doi.org/10.1371/journal.pcbi.1014549", "language": "en", "issued": { "date-parts": [ [ 2026, 7, 28 ] ] } }

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