Delta family protocadherins contribute to protoglomerular targeting of olfactory sensory neuron axons in the olfactory bulb.
The 4 matches
- [1] § Results › Olfactory sensory neurons from three developmental timepoints contain similar cells that differ by maturity ↔ 10x Genomics scRNAseq Zebrafish OSNs.R, lines 223–274 · score 0.84 · ascl1a, cfl1l, Early mature, cfap157, cldne, gng8
- [2] § Results › Olfactory sensory neurons from three developmental timepoints contain similar cells that differ by maturity ↔ 10x Genomics scRNAseq Zebrafish OSNs.R, lines 223–274 · score 0.58 · cxcr3.3, DESeq2, CD83, tnfb, immune, maturity
- [3] § Materials and methods › 10x genomics scRNA-seq analysis ↔ 10x Genomics scRNAseq Zebrafish OSNs.R, lines 1–53 · score 0.51 · cell Ranger, Seurat, Genomics, zebrafish
- [4] § Results › Odorant receptors co-expressed in the same OSN generally belong to the same OR subfamily ↔ 10x Genomics scRNAseq Zebrafish OSNs.R, lines 276–318 · score 0.51 · Or107, or106, or108, or109, or125, or126
Paper
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R · 366 lines · 19 KB · no license · 4 matches
10x Genomics scRNAseq Zebrafish OSNs.R at commit 7c431e8, no license · at the source
Overview
- Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Department of Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Department of Natural & Applied Sciences, Cheyney University, Cheyney, Pennsylvania, United States of America
Abstract
To understand how neural circuits are assembled, it is essential to identify and characterize the axonal guidance cues and receptors that determine the axonal trajectories and connections between neurons. We performed single-cell RNA sequencing of olfactory sensory neurons from zebrafish to identify candidate axonal guidance-related genes that are differentially expressed according to sensory axon target location in the olfactory bulb. Among the candidates we identified were several members of the non-clustered delta-protocadherin family of adhesion molecules. We found that two members of the delta1-protocadherin family, pcdh7b and pcdh11, are most highly expressed in sensory neurons that project to a specific identifiable neuropil in the early olfactory bulb called the DZ protoglomerulus. Knocking down either one of these protocadherins impairs the ability of sensory axons to terminate within the DZ protoglomerulus. Knockdown does not affect the ability of other sensory axons from terminating normally in a separate neuropil called the CZ protoglomerulus. In contrast, two members of the delta2-protocadherin family, pcdh10b and pcdh17, are most highly expressed in sensory neurons that project to the CZ protoglomerulus. Knocking down pcdh10b induces ectopic terminations of CZ projecting sensory axons. Knocking down pcdh17 induces substantial ectopic axonal trajectories and impairs CZ projecting sensory axons from finding and terminating in the CZ protoglomerulus. Knockdowns of either pcdh10b or pcdh17 do not affect DZ projecting sensory axons. We conclude that delta1-protocadherins help DZ projecting sensory axons enter and remain within the DZ protoglomerulus, while delta2-protocadherins help CZ projecting sensory axons navigate to the CZ protoglomerulus.
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DanielTBarnes/sc-RNAseq-of-Zebrafish-Olfactory-Sensory-Neurons
7c431e8e7cfb77d21ddfec72c6b5c1447289129a, 10 March 2025Availability: 1 check, the latest on 28 September 2026: the link answers
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Data
Datasets cited
- geo:GSE291626 — at NCBI GEO; found in the text, “10x genomics scRNA-seq analysis”
Data Availability
All scRNA-seq data is available in both raw and processed forms at the Gene Expression Omnibus accession code GSE291626. The scripts used to analyze the data are available at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 11 MeSH terms, 3 funders, 83 references, 1 RRID.
Cite
This paper
Barnes, D. T., Crenshaw, E. M. D., Curran, M. J., Herr, J. B., Devereaux, E. S., Seligman, C. D., & Raper, J. A. (2026). Delta family protocadherins contribute to protoglomerular targeting of olfactory sensory neuron axons in the olfactory bulb. PLoS genetics, 22(4), e1012090. https://
BibTeX
@article{barnes2026delta
author = {Barnes, Daniel T and Crenshaw, Ezekiel M D and Curran, Matthew J and Herr, Jessica B and Devereaux, Emily S and Seligman, Carly D and Raper, Jonathan A},
title = {{Delta family protocadherins contribute to protoglomerular targeting of olfactory sensory neuron axons in the olfactory bulb}},
journal = {PLoS genetics},
year = {2026},
month = apr,
volume = {22},
number = {4},
pages = {e1012090},
publisher = {PLOS},
issn = {1553-7390},
doi = {10.1371/
url = {https://
pmid = {41920906},
pmcid = {PMC13043054}
}
RIS
TY - JOUR
AU - Barnes, Daniel T
AU - Crenshaw, Ezekiel M D
AU - Curran, Matthew J
AU - Herr, Jessica B
AU - Devereaux, Emily S
AU - Seligman, Carly D
AU - Raper, Jonathan A
TI - Delta family protocadherins contribute to protoglomerular targeting of olfactory sensory neuron axons in the olfactory bulb
T2 - PLoS genetics
J2 - PLoS Genet
PY - 2026
DA - 2026/
VL - 22
IS - 4
SP - e1012090
SN - 1553-7390
PB - PLOS
DO - 10.1371/
UR - https://
LA - en
ER -
CSL-JSON
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