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GPR37 modulates body weight and insulin sensitivity in a sex-biased manner.

Overview

Authors: Mariam Ahmed1, Mariela Nunez Santos1, Karen Abdelsayed1, Corrine Liu1, Nimco Xuseen1, Pokuaa Adwoa Boakye1, Sharon Owino1,2
ORCID iDs: Sharon Owino
  1. Neuroscience Program, Smith College, Northampton, Massachusetts, United States of America
  2. Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia, United States of America
Institutions: Smith College (United States); Morehouse School of Medicine (United States)
Journal: PloS one, volume 21, issue 5, article e0349406
Dates: received 16 September 2025; accepted 29 April 2026; published online 28 May 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1371/journal.pone.0349406 · PMID 42207848 · PMCID PMC13218456 · OpenAlex W7162675205
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Statistics
MeSH: Body Weight*, Insulin Resistance*, Receptors, G-Protein-Coupled*, Animals, Energy Metabolism, Female, Glucose, Insulin, Male, Mice, Mice, Knockout (* major topic)
Topic: Receptor Mechanisms and Signaling (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: American Heart Association (23AIREA961441)
Citations: not cited yet (Europe PMC); 18 references in the paper

Abstract

Metabolic disorders are a growing public health concern in the United States, with approximately 40% of the population living with obesity. The urgent need for novel therapeutic targets has driven interest in G protein–coupled receptors (GPCRs), a diverse group of seven-transmembrane receptors that regulate various physiological processes and represent a significant portion of current drug targets. In this study, we investigated the role of GPR37, a brain-enriched orphan GPCR, in systemic glucose regulation. Using heterozygous Gpr37 + /- mice, we assessed body weight, glucose tolerance, and insulin sensitivity. Male Gpr37 + /- mice exhibited significantly reduced body weight, an enhanced metabolic response to fasting, and increased insulin sensitivity compared to wild-type controls. These findings indicate that reduced Gpr37 gene dosage is associated with metabolic efficiency, particularly in the regulation of glucose metabolism, and reveal a previously unrecognized sex-biased role for GPR37 in systemic energy homeostasis. Taken together, these data suggest that GPR37 contributes to metabolic regulation and represents a candidate pathway for further pharmacological and tissue-specific study.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data

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Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 2, 28 September 2026

  • Funding: added American Heart Association: 23AIREA961441

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 11 MeSH terms, 16 references.

Cite

This paper

Ahmed, M., Santos, M. N., Abdelsayed, K., Liu, C., Xuseen, N., Boakye, P. A., & Owino, S. (2026). GPR37 modulates body weight and insulin sensitivity in a sex-biased manner. PloS one, 21(5), e0349406. https://doi.org/10.1371/journal.pone.0349406

BibTeX

@article{ahmed2026gpr37,
author = {Ahmed, Mariam and Santos, Mariela Nunez and Abdelsayed, Karen and Liu, Corrine and Xuseen, Nimco and Boakye, Pokuaa Adwoa and Owino, Sharon},
title = {{GPR37 modulates body weight and insulin sensitivity in a sex-biased manner}},
journal = {PloS one},
year = {2026},
month = may,
volume = {21},
number = {5},
pages = {e0349406},
publisher = {PLOS},
issn = {1932-6203},
doi = {10.1371/journal.pone.0349406},
url = {https://doi.org/10.1371/journal.pone.0349406},
pmid = {42207848},
pmcid = {PMC13218456}
}

RIS

TY - JOUR
AU - Ahmed, Mariam
AU - Santos, Mariela Nunez
AU - Abdelsayed, Karen
AU - Liu, Corrine
AU - Xuseen, Nimco
AU - Boakye, Pokuaa Adwoa
AU - Owino, Sharon
TI - GPR37 modulates body weight and insulin sensitivity in a sex-biased manner
T2 - PloS one
J2 - PLoS One
PY - 2026
DA - 2026/05/28
VL - 21
IS - 5
SP - e0349406
SN - 1932-6203
PB - PLOS
DO - 10.1371/journal.pone.0349406
UR - https://doi.org/10.1371/journal.pone.0349406
LA - en
ER -

CSL-JSON

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