Astrocyte TrkB.T1 Deficiency Disrupts Glutamatergic Synaptogenesis and Astrocyte-Synapse Interactions.
Overview
Abstract
Perisynaptic astrocyte processes (PAPs) contact pre- and postsynaptic elements to provide structural and functional support to synapses. Accumulating research demonstrates that the contact of synapses by PAPs is critical for synapse formation, stabilization, and plasticity. The specific signaling pathways that govern these astrocyte–synapse interactions, however, remain to be elucidated. Herein, we demonstrate the role of the astrocyte TrkB.T1 receptor, a truncated isoform of the canonical receptor for brain-derived neurotrophic factor (BDNF), in modulating astrocyte–synapse interactions and excitatory synapse development. Neuron–astrocyte coculture studies revealed that loss of astrocyte TrkB.T1 disrupts the formation of PAPs. To elucidate the role of TrkB.T1 in synapse development, we conditionally deleted TrkB.T1 in astrocytes in mice of either sex. Synaptosome preparations were employed to probe for TrkB.T1 localization at the PAP, and confocal three-dimensional microscopy revealed a significant reduction in synapse density and astrocyte–synapse interactions across development in the absence of astrocytic TrkB.T1. Furthermore, conditional knock-out of astrocyte TrkB.T1 alters motor learning and experience-dependent astrocyte–synapse interactions. These findings suggest that BDNF/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- portal.brain-map.org/
atlases-and-data/ , at Allen Brain Map; found in the text, “TrkB.T1 is enriched at the synapse in vivo”bkp
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 4 keywords, 16 MeSH terms, 2 funders, 70 references, 1 RRID.
Cite
This paper
Pinkston, B. T. C., Browning, J. L., Larson, A. P., & Olsen, M. L. (2026). Astrocyte TrkB.T1 Deficiency Disrupts Glutamatergic Synaptogenesis and Astrocyte-Synapse Interactions. The Journal of neuroscience : the official journal of the Society for Neuroscience, 46(31), e2002242026. https://
BibTeX
@article{pinkston2026ast
author = {Pinkston, Beatriz T C and Browning, Jack L and Larson, Amelie P and Olsen, Michelle L},
title = {{Astrocyte TrkB.T1 Deficiency Disrupts Glutamatergic Synaptogenesis and Astrocyte-Synapse Interactions}},
journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
year = {2026},
month = aug,
volume = {46},
number = {31},
pages = {e2002242026},
publisher = {Society for Neuroscience},
issn = {0270-6474},
doi = {10.1523/
url = {https://
pmid = {42431834},
pmcid = {PMC13446085}
}
RIS
TY - JOUR
AU - Pinkston, Beatriz T C
AU - Browning, Jack L
AU - Larson, Amelie P
AU - Olsen, Michelle L
TI - Astrocyte TrkB.T1 Deficiency Disrupts Glutamatergic Synaptogenesis and Astrocyte-Synapse Interactions
T2 - The Journal of neuroscience : the official journal of the Society for Neuroscience
J2 - J Neurosci
PY - 2026
DA - 2026/
VL - 46
IS - 31
SP - e2002242026
SN - 0270-6474
PB - Society for Neuroscience
DO - 10.1523/
UR - https://
LA - en
ER -
CSL-JSON
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