Locally synthesized glycyl aminoacyl-tRNA synthetase is important for local translation in neurons.
The 1 match
- [1] § Results › GARS1 protein is in proximity to tRNAGly in neurites ↔ probability density_v2_6_26_2025.py, lines 15–114 · score 0.60 · 0–20 um, neurite length, segments, proximal, distal, NS
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The authors' code
Python · 126 lines · 5.3 KB · no license · 1 match
probability density_v2_6_26_2025.py at commit 6b90b01, no license · at the source
Overview
Abstract
Regulation of gene expression is essential for neuronal development and function. A prominent regulatory mechanism involves synthesis of proteins at their activity site. Such local protein synthesis enables neurons to respond rapidly and tightly to stimuli. Key components of the translation machinery, including mRNA and ribosomes, were identified in subcellular regions of neurons. Yet, the role of tRNAs and their charging enzymes, aminoacyl-tRNA synthetases (ARS), in this process remains largely unclear. Here, we demonstrate that glycyl-tRNA synthetase (Gars1) mRNA is abundant in neurites and undergoes local translation, producing GARS1 protein. Notably, Gars1 mRNA colocalizes with mitochondria in a translation-dependent manner, with its coding sequence (CDS) sufficient to direct this association. The localized GARS1 protein is in close proximity to tRNAGly, and disrupting their proximity impairs local protein synthesis in neurites. These findings establish the functional importance of GARS1 and tRNAGly in neuritic translation and highlight mitochondria as hubs for mRNA transport and translation.
Reproduced under the paper's license (CC BY), from the paper cited above.
Repository
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tylerbrent/gars1-
6b90b016099ccc61cb5c34aaf408a55394c52902, 2 March 2026Availability: 1 check, the latest on 29 September 2026: the link answers
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- README.md — Text, 1 line, shown from its source
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Data
Datasets cited
- arrayexpress:E-MTAB-4978
— at ArrayExpress; found in the text, “Bioinformatics analysis” - figshare:31449445 — at figshare; found in “Data Availability”
- geo:GSE121069 — at NCBI GEO; found in the text, “Bioinformatics analysis”
- rcsb.org/
structure/ — at PDB; found in the text, “Disrupting GARS1 and tRNA Gly proximity…”4kr2
Data Availability
Raw images are deposited in Zenodo (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 10 MeSH terms, 1 funder, 82 references.
Cite
This paper
de Leon, T. B., Golani-Armon, A., Cohen, B., & Arava, Y. S. (2026). Locally synthesized glycyl aminoacyl-tRNA synthetase is important for local translation in neurons. Life science alliance, 9(6), e202603630. https://
BibTeX
@article{deleon2026local
author = {de Leon, Tyler Brent and Golani-Armon, Adi and Cohen, Bar and Arava, Yoav S},
title = {{Locally synthesized glycyl aminoacyl-tRNA synthetase is important for local translation in neurons}},
journal = {Life science alliance},
year = {2026},
month = apr,
volume = {9},
number = {6},
pages = {e202603630},
publisher = {Life Science Alliance LLC},
issn = {2575-1077},
doi = {10.26508/
url = {https://
pmid = {41986236},
pmcid = {PMC13084160}
}
RIS
TY - JOUR
AU - de Leon, Tyler Brent
AU - Golani-Armon, Adi
AU - Cohen, Bar
AU - Arava, Yoav S
TI - Locally synthesized glycyl aminoacyl-tRNA synthetase is important for local translation in neurons
T2 - Life science alliance
J2 - Life Sci Alliance
PY - 2026
DA - 2026/
VL - 9
IS - 6
SP - e202603630
SN - 2575-1077
PB - Life Science Alliance LLC
DO - 10.26508/
UR - https://
LA - en
ER -
CSL-JSON
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