TGF-β and IL-4 + IL-13 induce neuroplasticity in an <i>in vitro</i> model of hPSC-derived sensory neurons.
Overview
- Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands
- Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen (UMCG), University of Groningen, Groningen, Netherlands
Abstract
Chronic type 2 inflammation is known to drive the neuroplasticity of both afferent and efferent vagal nerves innervating many organs. This results in increased neuronal density and sensitivity, possibly contributing to pathologies such as eczema and asthma. However, the mechanisms driving these neuronal changes, particularly in sensory pathways, remain poorly understood, and appropriate in vitro models for their study are lacking. Here, we describe the differentiation of sensory neurons from human pluripotent stem cells. The generation of sensory neurons was validated by verifying the expression of sensory neuron markers, such as β3-tubulin, PGP9.5, TRPV1, Nav1.8, and Piezo1/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- geo:GSE190499, at NCBI GEO; found in the text, “Development and validation of a hPSC-derived…”
Other data links
- ncbi.nlm.nih.gov/
geo , NCBI; found in the text, “RNA sequencing analysis”
Data availability statement
The datasets presented in this study can be found in online repositories. The names of the repository/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 6 authors, 6 keywords, 8 MeSH terms, 2 funders, 91 references.
Cite
This paper
Koster, C. S., Bos, I. S. T., Lavitola, C., Balogh, M., Melgert, B. N., & Gosens, R. (2026). TGF-β and IL-4 + IL-13 induce neuroplasticity in an &
BibTeX
@article{koster2026tgf,
author = {Koster, Carli S and Bos, I Sophie T and Lavitola, Chiara and Balogh, Mihaly and Melgert, Barbro N and Gosens, Reinoud},
title = {{TGF-β and IL-4 + IL-13 induce neuroplasticity in an \&
journal = {Frontiers in immunology},
year = {2026},
month = mar,
volume = {17},
pages = {1705880},
publisher = {Frontiers Media SA},
issn = {1664-3224},
doi = {10.3389/
url = {https://
pmid = {41853271},
pmcid = {PMC12992014}
}
RIS
TY - JOUR
AU - Koster, Carli S
AU - Bos, I Sophie T
AU - Lavitola, Chiara
AU - Balogh, Mihaly
AU - Melgert, Barbro N
AU - Gosens, Reinoud
TI - TGF-β and IL-4 + IL-13 induce neuroplasticity in an &
T2 - Frontiers in immunology
J2 - Front Immunol
PY - 2026
DA - 2026/
VL - 17
SP - 1705880
SN - 1664-3224
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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"family": "Melgert",
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"URL": "https://
"language": "en",
"issued": {
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