Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice.
The 7 matches · 2 of them tie a paragraph to a whole file, not to given lines: weak matches, whose lines are not tinted
- [1] § Results › Spatial patterns of gene expression in the forebrain ↔ preprocessing/functions/umap_feature_expression_plot.R, lines 195–263 · score 0.68 · Adora2a, Ppp1r2, Drd1, Drd2, Ecel1, Gad2
- [2] § Results › Spatial patterns of gene expression in the forebrain ↔ preprocessing/risperidone/ris-umap-genes.R, the whole file · a weak match · score 0.67 · Adora2a, Ppp1r2, Drd1, Drd2, Ecel1, Gad2
- [3] § Methods › Cluster identification and marker validation ↔ preprocessing/functions/functions-spatial-data.R, lines 71–132 · score 0.66 · Principal component, Seurat, UMAP, neighbor, variable
- [4] § Methods › Cluster identification and marker validation ↔ preprocessing/old-scripts/deseq-test-analysis.R, lines 392–476 · score 0.64 · variance stabilizing transformation, log2 fold change, Clusters
- [5] § Methods › Differential gene expression analysis ↔ preprocessing/functions/statistics-functions-v2.R, lines 186–234 · score 0.57 · log2 fold change, quantile normalization, assignments, clustering resolution, transcript
- [6] § Methods › Peak processing, validation, and custom reference generation ↔ preprocessing/old-scripts/reduction-peaks.R, lines 333–414 · score 0.52 · amplitude, log10, coverage, BAM, summit, ratio
- [7] § Results › Enrichment analysis ↔ preprocessing/clozapine/supplementaryAnalysis_paper_03.12.2025.R, the whole file · a weak match · score 0.50 · Cacna1i, Bhlhe40, Phactr3, Homer1, Kalrn, Olig2
Paper
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The authors' code
R · 267 lines · 10 KB · no license · 1 match
- umap_feature_expression_plot <- function(ldopa_integrate,
- spatial_data,
- type_data,
- peak_id,
- samples,
- plot_title = "UMAP Visualization with Feature Expression", # Nowy argument dla tytułu
- min_percentile = 0.01,
- max_percentile = 0.99,
- normalization = TRUE,
- low_color = "gray99",
- high_color = "red",
- na_color = "grey99",
- point_size = 1,
- alpha = 1,
- save_to_png = FALSE, # Nowy argument: czy zapisać do PNG
- file_path = NULL, # Nowy argument: ścieżka do zapisu
- width = 8, # Opcjonalny argument: szerokość wykresu
- height = 6, # Opcjonalny argument: wysokość wykresu
- dpi = 300) { # Opcjonalny argument: rozdzielczość
- # Wyciągnij koordynaty UMAP oraz barcodes
- umap_coordinates <- ldopa_integrate@reductions$[email hidden]
- umap_table <- data.frame(
- barcode = rownames(umap_coordinates),
- X = umap_coordinates[, 1], # Oś X
- Y = umap_coordinates[, 2] # Oś Y
- )
- # Przygotowanie tabeli ekspresji
- expression_table <- spatial_data[[type_data]]$data[peak_id, ] %>%
- as.data.frame() %>%
- dplyr::rename(expression = ".") %>%
- rownames_to_column("sample_barcode") %>%
- separate("sample_barcode", c("sample", "barcode"), sep = "_") %>%
- left_join(., spatial_data$bcs_information, by = c("barcode", "sample")) %>%
- filter(sample %in% samples) %>%
- mutate(
- max_perc = as.numeric(quantile(expression, probs = c(max_percentile), na.rm = TRUE)),
- min_perc = as.numeric(quantile(expression, probs = c(min_percentile), na.rm = TRUE)),
- expression = ifelse(expression > max_perc, max_perc, expression),
- expression = ifelse(expression < min_perc, min_perc, expression),
- expression = if (normalization == TRUE) {
- (expression - min(expression, na.rm = TRUE)) / (max(expression, na.rm = TRUE) - min(expression, na.rm = TRUE))
- } else {
- expression
- },
- barcode = paste(sample, barcode, sep = "_")
- ) %>%
- dplyr::select(barcode, expression)
- # Merge dwóch tabel
- merged_table <- dplyr::left_join(umap_table, expression_table, by = "barcode")
- # Sprawdzenie poprawności mergu
- all_matched <- nrow(merged_table) == nrow(umap_table)
- missing_matches <- sum(is.na(merged_table$expression))
- if (!all_matched || missing_matches > 0) {
- cat("Uwaga: Niektóre wiersze nie zostały dopasowane. Niedopasowane wiersze:", missing_matches, "\n")
- }
- # Tworzenie wykresu
- plot <- ggplot(merged_table, aes(x = X, y = Y, fill = expression)) +
- geom_point(shape = 21, size = point_size, alpha = alpha, stroke = 0) + # Punkty bez obramówki
- scale_fill_gradient(low = low_color, high = high_color, na.value = na_color) + # Skala kolorów
- labs(
- title = plot_title, # Użycie nowego argumentu dla tytułu
- x = "UMAP 1",
- y = "UMAP 2",
- fill = "Expression"
- ) +
- theme_minimal() +
- theme(
- panel.grid.major = element_blank(),
- panel.grid.minor = element_blank(),
- panel.background = element_blank(),
- axis.line = element_line(colour = "black")
- )
- # Opcjonalny zapis do pliku
- if (save_to_png) {
- # Ustawienie domyślnej ścieżki, jeśli nie została podana
- if (is.null(file_path)) {
- file_path <- getwd()
- }
- # Upewnienie się, że ścieżka istnieje
- if (!dir.exists(file_path)) {
- dir.create(file_path, recursive = TRUE)
- cat("Utworzono katalog:", file_path, "\n")
- }
- # Przygotowanie bezpiecznej nazwy pliku
- safe_title <- stringr::str_replace_all(plot_title, "[: ]", "_")
- safe_title <- stringr::str_replace_all(safe_title, "_+", "_")
- file_name <- paste0(safe_title, ".png")
- full_path <- file.path(file_path, file_name)
- # Dostosowanie motywu do białego tła
- plot_to_save <- plot + theme(
- panel.background = element_rect(fill = "white", color = NA),
- plot.background = element_rect(fill = "white", color = NA)
- )
- # Zapis wykresu
- ggsave(filename = full_path, plot = plot_to_save, width = width, height = height, dpi = dpi)
- cat("Wykres zapisano do pliku:", full_path, "\n")
- }
- return(plot)
- }
- #
- # # Wywołanie funkcji z Twoimi danymi
- # plot <- umap_feature_expression_plot(
- # ldopa_integrate = ldopa_integrate,
- # spatial_data = ldopa_st_data,
- # type_data = "quantile_normalize_resolution_1",
- # peak_id = "ldopa-peak-17758",
- # samples = c(samples_saline, samples_ldopa),
- # min_percentile = 0.00,
- # max_percentile = 1,
- # normalization = TRUE,
- # low_color = "gray99",
- # high_color = "red",
- # na_color = "grey99",
- # point_size = 1,
- # alpha = 1
- # )
- #
- # # Wyświetlenie wykresu
- # print(plot)
- umap_gene_expression_plot <- function(spatial_data,
- type_data,
- ncol,
- gene,
- ldopa_integrate,
- samples,
- min_percentile = 0.01,
- max_percentile = 0.99,
- normalization = TRUE,
- low_color = "gray95",
- high_color = "red",
- na_color = "grey99",
- point_size = 1,
- alpha = 1,
- save_to_png = FALSE, # Nowy argument: czy zapisać do PNG
- file_path = NULL, # Nowy argument: ścieżka do zapisu
- width = 8, # Opcjonalny argument: szerokość wykresu
- height = 6, # Opcjonalny argument: wysokość wykresu
- dpi = 300, # Opcjonalny argument: rozdzielczość
- ...) {
- # Wyciągnięcie wektora peak_id dla danego genu
- vector_peak <- spatial_data[[type_data]]$annotate %>%
- dplyr::filter(gene_name == gene) %>%
- dplyr::select(peak_id) %>%
- pull(peak_id)
- print(paste("Peaki dla genu", gene, ":", paste(vector_peak, collapse = ", ")))
- # Lista do przechowywania wykresów
- plot_list <- list()
- # Iteracja po każdym peak_id
- for (peak in vector_peak) {
- # Tworzenie tytułu wykresu
- plot_title <- paste(gene, peak, sep = ": ")
- # Generowanie wykresu UMAP
- plot <- umap_feature_expression_plot(
- ldopa_integrate = ldopa_integrate,
- spatial_data = spatial_data,
- type_data = type_data,
- peak_id = peak,
- samples = samples,
- plot_title = plot_title,
- min_percentile = min_percentile,
- max_percentile = max_percentile,
- normalization = normalization,
- low_color = low_color,
- high_color = high_color,
- na_color = na_color,
- point_size = point_size,
- alpha = alpha,
- save_to_png = save_to_png, # Przekazanie argumentu
- file_path = file_path, # Przekazanie argumentu
- width = width, # Przekazanie argumentu
- height = height, # Przekazanie argumentu
- dpi = dpi # Przekazanie argumentu
- )
- # Dodanie wykresu do listy
- plot_list[[peak]] <- plot
- # Opcjonalne wyświetlenie wykresu
- print(plot_title)
- print(plot)
- }
- # Organizacja wykresów w siatkę
- combined_plot <- patchwork::wrap_plots(plot_list, ncol = ncol, guides = "collect") +
- patchwork::plot_annotation(title = paste("UMAP Plots dla Genu:", gene))
- # Wyświetlenie połączonego wykresu
- print(combined_plot)
- # Opcjonalny zapis połączonego wykresu
- if (save_to_png) {
- # Ustawienie domyślnej ścieżki, jeśli nie została podana
- if (is.null(file_path)) {
- file_path <- getwd()
- }
- # Upewnienie się, że ścieżka istnieje
- if (!dir.exists(file_path)) {
- dir.create(file_path, recursive = TRUE)
- cat("Utworzono katalog:", file_path, "\n")
- }
- # Przygotowanie bezpiecznej nazwy pliku
- safe_title <- gsub("[/:*?\"<>|\\s]", "_", paste("Combined_", gene, sep = ""))
- file_name <- paste0(safe_title, ".png")
- full_path <- file.path(file_path, file_name)
- # # Zapis połączonego wykresu
- # ggsave(filename = full_path, plot = combined_plot, width = width, height = height, dpi = dpi)
- # cat("Połączony wykres zapisano do pliku:", full_path, "\n")
- }
- # Zwrócenie listy wykresów oraz połączonego wykresu
- return(list(individual_plots = plot_list, combined_plot = combined_plot))
- }
- umap_gene_expression_plot(
- spatial_data = risperidone_st_data_half,
- type_data = "quantile_normalize_resolution_0.4",
- ncol = 2,
- gene = "Gad2",
- ldopa_integrate = risperidone_integrate_half,
- samples = c(samples_saline, samples_risperidone),
- min_percentile = 0.01,
- max_percentile = 0.99,
- normalization = TRUE,
- low_color = "gray95",
- high_color = "red",
- na_color = "grey99",
- point_size = 1.5,
- alpha = 1,
- save_to_png = TRUE, # Włączenie zapisu do PNG
- file_path = "./results/risperidone/umap-gene-expression", # Podanie ścieżki do katalogu
- width = 10, # Szerokość wykresu w calach
- height = 8, # Wysokość wykresu w calach
- dpi = 300 # Rozdzielczość
- )
- # Definiowanie wektora z nazwami genów
- genes <- c("Drd1", "Drd2", "Adora2a", "Ppp1r1b", "Ppp1r2", "Gad2", "Ecel1", "Gfra1")
umap_feature_expression_plot.R at commit 03f0a59, no license · at the source
Overview
- Department of Molecular Neuropharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
- Laboratory of Pharmacogenomics, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland
Abstract
Introduction: Risperidone is a widely used antipsychotic that reduces psychotic symptoms through modulation of monoaminergic signaling. At the cellular level, however, its effects extend beyond receptor antagonism and induce spatially discrete transcriptional responses across forebrain structures, particularly in the basal ganglia and frontal cortex.
Methods: We applied sequencing-based spatial transcriptomics to the forebrain of male C57BL/
Results: Acute risperidone treatment significantly affected 95 transcripts across 12 brain regions. The most prominent transcriptional changes were concentrated in ventral forebrain structures, including the olfactory tubercle (25 differentially expressed transcripts), diagonal band nucleus (22), corpus callosum and commissures (13), and lateral septal nucleus (9). Importantly, 18 of these 95 genes have previously been implicated in schizophrenia, including Olig2, Smpd3, and Cacna1i.
Discussion: Together, these findings indicate that acute treatment with risperidone in male mice exerts pronounced molecular effects in medial and ventral forebrain regions with high oligodendrocyte and glial cell abundance. Moreover, enrichment analysis points to a molecular convergence between risperidone-induced transcription and genetic pathways implicated in schizophrenia.
Reproduced under the paper's license (CC BY), from the paper cited above.
Repositories
Its files are read in the Code ↔ Paper reader above, with 7 matches between paragraphs and lines of code.
macs3-project/MACS
c5443190e3edfeb301cc94acf450e2b2c026a223, 25 September 2026Availability: 1 check, the latest on 28 September 2026: the link answers
- 28 September 2026: the link answers
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ippas/ifpan-janrod-spatial
03f0a59895f28cd124562d4e07b397f41684a177, 1 September 2026Availability: 1 check, the latest on 28 September 2026: the link answers
- 28 September 2026: the link answers
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functions/ , R, 13 lineswrite_cluster_list_to_xl sx.R - preprocessing/
functions/ , R, 168 lineszero-nonzero-ratio.R - preprocessing/
installing-require-packa , R, 28 linesges.R - preprocessing/
ldopa/ , R, 314 linesldopa-analysis.R - preprocessing/
ldopa/ , R, 139 linesldopa-permutation-fdr.R - preprocessing/
ldopa/ , R, 1 linetest-umap-single-gene.R - preprocessing/
old-scripts/ , R, 143 linesanalysis-data-normalize. R - preprocessing/
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old-scripts/ , R, 89 linesgenerate-raport.R - preprocessing/
old-scripts/ , R, 324 linesold-code.R - preprocessing/
old-scripts/ , R, 1,041 linespreparation-functions.R - preprocessing/
old-scripts/ , R, 117 linespreparation-visualizatio n.R - preprocessing/
old-scripts/ , Shell, 167 linesprepare-annotate-peaks.s h - preprocessing/
old-scripts/ , R, 73 linesread-data.R - preprocessing/
old-scripts/ , R, 584 lines, 1 matchreduction-peaks.R - preprocessing/
old-scripts/ , Shell, 91 linesspaceranger-analysis.sh - preprocessing/
old-scripts/ , R, 127 linesstatistics.R - preprocessing/
old-scripts/ , R, 110 linesvisualization-seurat.R - preprocessing/
prepare-annotate-peaks-v , Shell, 150 lines2.sh - preprocessing/
prepare-annotate-peaks.s , Shell, 167 linesh - preprocessing/
python/ , Python, 186 linesscripts/ extract-coverage-for-gen es-test.py - preprocessing/
python/ , Python, 1 linesrc/ __init__.py - preprocessing/
python/ , Python, 152 linessrc/ bam_coverage_utils.py - preprocessing/
python/ , Python, 56 linessrc/ mouse_annotations_downlo ader.py - preprocessing/
python/ , Python, 317 linessrc/ plotting_functions.py - preprocessing/
python/ , Python, 29 linessrc/ workflow_utils.py - preprocessing/
pz-1190/ , R, 178 linespz-1190-analysis-half.R - preprocessing/
pz-1190/ , R, 178 linespz-1190-analysis.R - preprocessing/
reduction-peaks.R , R, 584 lines - preprocessing/
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risperidone-3q29/ , R, 35 linesadd-hoc-analysis/ ris3q29-meanEgr3Usp48.R - preprocessing/
risperidone-3q29/ , R, 50 linesadd-hoc-analysis/ ris3q29-meanGenesPerSamp le.R - preprocessing/
risperidone-3q29/ , R, 229 linesadd-hoc-analysis/ ris3q29-nr3.R - preprocessing/
risperidone-3q29/ , R, 100 linesadd-hoc-analysis/ ris3q29-umap-25samples.R - preprocessing/
risperidone-3q29/ , R, 1,475 linesclustering-spatial-conti nuity/ 01_evaluateClusteringSpa tialContinuity_PAS_CHAOS _ASW.R - preprocessing/
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risperidone-3q29/ , R, 728 linesedgeR/ edger_cross_cell_contras ts_by_cluster_16.06.2026 .R - preprocessing/
risperidone-3q29/ , R, 751 linesedgeR/ edger_cross_cell_contras ts_by_cluster_29.06.2026 .R - preprocessing/
risperidone-3q29/ , R, 29 linesedgeR/ investigation_logFC_edge r.R - preprocessing/
risperidone-3q29/ , R, 351 linesedgeR/ prepare_logCPM_per_sampl e_for_clusters.R - preprocessing/
risperidone-3q29/ , R, 687 linesedgeR/ pseudobulk_edgeR_n25Samp les_min15Spots_02.07.202 6.R - preprocessing/
risperidone-3q29/ , R, 301 linesedgeR/ ris3q29_edgerInteraction _test.R - preprocessing/
risperidone-3q29/ , R, 444 linesedgeR/ ris3q29_edgerMarginaProp ortional_permutationFDRI nteraction.R - preprocessing/
risperidone-3q29/ , R, 626 linesedgeR/ ris3q29_edger_MarginalPr oportional.R - preprocessing/
risperidone-3q29/ , R, 164 linesedgeR/ ris3q29_edger_scatterplo tLog2FC.R - preprocessing/
risperidone-3q29/ , R, 594 linesedgeR/ ris3q29_prepareExpressio nByClusters_29.06.2026.R - preprocessing/
risperidone-3q29/ , R, 183 linesedgeR/ ris3q29_visSumQN_heatmap .R - preprocessing/
risperidone-3q29/ , R, 81 linesheatmap/ ris3q29-complexheatmap-f unc-test.R - preprocessing/
risperidone-3q29/ , R, 147 linesheatmap/ ris3q29-complexheatmap-f unc-v1.10.R - preprocessing/
risperidone-3q29/ , R, 159 linesheatmap/ ris3q29-complexheatmap-f unc-v1.11.R - preprocessing/
risperidone-3q29/ , R, 170 linesheatmap/ ris3q29-complexheatmap-f unc-v1.12.R - preprocessing/
risperidone-3q29/ , R, 152 linesheatmap/ ris3q29-complexheatmap-f unc-v1.13.R - preprocessing/
risperidone-3q29/ , R, 188 linesheatmap/ ris3q29-complexheatmap-f unc-v1.14.R - preprocessing/
risperidone-3q29/ , R, 127 linesheatmap/ ris3q29-complexheatmap-f unc-v1.3.R - preprocessing/
risperidone-3q29/ , R, 130 linesheatmap/ ris3q29-complexheatmap-f unc-v1.4.R - preprocessing/
risperidone-3q29/ , R, 134 linesheatmap/ ris3q29-complexheatmap-f unc-v1.6.R - preprocessing/
risperidone-3q29/ , R, 136 linesheatmap/ ris3q29-complexheatmap-f unc-v1.7.R - preprocessing/
risperidone-3q29/ , R, 143 linesheatmap/ ris3q29-complexheatmap-f unc-v1.8.R - preprocessing/
risperidone-3q29/ , R, 133 linesheatmap/ ris3q29-complexheatmap-f unc1.5.R - preprocessing/
risperidone-3q29/ , R, 142 linesheatmap/ ris3q29-complexheatmap-f unction-v1.1.R - preprocessing/
risperidone-3q29/ , R, 113 linesheatmap/ ris3q29-complexheatmap-f unction-v1.R - preprocessing/
risperidone-3q29/ , R, 263 linesheatmap/ ris3q29-globalHeatmap-te st.R - preprocessing/
risperidone-3q29/ , R, 321 linesheatmap/ ris3q29-globalSummary-v2 .R - preprocessing/
risperidone-3q29/ , R, 442 linesinteraction-heatmap-16.1 0.2025/ plot_heatmap_zscoreSalin eType_customDist.R - preprocessing/
risperidone-3q29/ , R, 295 linesris3q29-analysis-seurat- v2.R - preprocessing/
risperidone-3q29/ , R, 333 linesris3q29-analysis-seurat. R - preprocessing/
risperidone-3q29/ , R, 106 linesris3q29-complexheatmap.R - preprocessing/
risperidone-3q29/ , R, 116 linesris3q29-deletion-genes-h eatmap.R - preprocessing/
risperidone-3q29/ , R, 389 linesris3q29-edgerStatistics. R - preprocessing/
risperidone-3q29/ , R, 61 linesris3q29-find-markers.R - preprocessing/
risperidone-3q29/ , R, 159 linesris3q29-heatmap-dev2.R - preprocessing/
risperidone-3q29/ , R, 191 linesris3q29-statistcs.R - preprocessing/
risperidone-3q29/ , R, 186 linesris3q29-statistics-v3.R - preprocessing/
risperidone-3q29/ , R, 120 linesris3q29-visualization-re sults-test.R - preprocessing/
risperidone-3q29/ , R, 336 linesris3q29_preapreMeanExpre ssionPersSampleMin20spot s_09.06.2026.R - preprocessing/
risperidone-3q29/ , R, 246 linesris3q39-heatmap.R - preprocessing/
risperidone-3q29/ , R, 104 linessandbox/ sandbox-15.10.2025/ heatmap-interaction-zsco reSalinePerGenotype.R - preprocessing/
risperidone-3q29/ , R, 46 linessandbox/ sandbox-15.10.2025/ heatmap-test-zscore.R - preprocessing/
risperidone-3q29/ , R, 101 linessandbox/ sandbox-15.10.2025/ heatmap-test-zscore_v2.R - preprocessing/
risperidone-3q29/ , R, 113 linessandbox/ sandbox-15.10.2025/ heatmap-test-zscore_v3-w twtSalienZscore.R - preprocessing/
risperidone-3q29/ , R, 58 linessandbox/ sandbox-15.10.2025/ heatmap-test-zsocre-allS amplesHeatmap.R - preprocessing/
risperidone-3q29/ , R, 251 linessandbox/ sandbox-15.10.2025/ plot_gene_heatmap_group_ means_refZscore_from_bun dle.R - preprocessing/
risperidone-3q29/ , R, 170 linessummary-statistics-debug / compute-data-summary-deb ug.R - preprocessing/
risperidone-3q29/ , R, 138 linessummary-statistics-debug / summarize_and_test-debug -v2.R - preprocessing/
risperidone-3q29/ , R, 155 linessummary-statistics-debug / summarize_and_test-debug .R - preprocessing/
risperidone-3q29/ , R, 40 linessummary_clusters/ summarize_cluster_barcod es_per_sample.R - preprocessing/
risperidone/ , R, 139 linescustomize-clusters.R - preprocessing/
risperidone/ , R, 102 linesfunction-statistics.R - preprocessing/
risperidone/ , R, 104 linesgene-count-per-spot.R - preprocessing/
risperidone/ , R, 89 linesgenerate-raport.R - preprocessing/
risperidone/ , R, 187 linesjackcraig-prepare-spatia ldata.R - preprocessing/
risperidone/ , R, 67 lines, 1 matchris-umap-genes.R - preprocessing/
risperidone/ , R, 762 linesris_permutataion_minSpot 15_16.03.2026.R - preprocessing/
risperidone/ , R, 201 linesrisperidone-analysis-hal f-seurat5.R - preprocessing/
risperidone/ , R, 149 linesrisperidone-analysis.R - preprocessing/
risperidone/ , R, 766 linesrisperidone-half-analysi s-defaultReference_17.03 .2026.R - preprocessing/
risperidone/ , R, 320 linesrisperidone-half-analysi s.R - preprocessing/
risperidone/ , R, 188 linesrisperidone-half-statist ics-spotThreshold15-11.0 2.2026.R - preprocessing/
risperidone/ , R, 101 linesrisperidone-half-statist ics.R - preprocessing/
risperidone/ , R, 2 linesrisperidone-median-trans cript-per-spot.R - preprocessing/
risperidone/ , R, 135 linesrisperidone_findMarkers_ 12.02.2026.R - preprocessing/
risperidone/ , R, 69 linesspatial-cluster-stabilit y/ prepareData_toSilhouette _v1_2026.R - preprocessing/
risperidone/ , Python, 169 linesspatial-cluster-stabilit y/ run_sdmbench_chaos_pas/ run_sdmbench_chaos_pas_v 1_27.04.2026.py - preprocessing/
risperidone/ , Python, 195 linesspatial-cluster-stabilit y/ run_sdmbench_chaos_pas/ run_sdmbench_chaos_pas_v 2_27.04.2026.py - preprocessing/
risperidone/ , Python, 192 linesspatial-cluster-stabilit y/ run_sdmbench_chaos_pas/ run_sdmbench_chaos_pas_v 3_27.04.2026.py - preprocessing/
risperidone/ , Python, 229 linesspatial-cluster-stabilit y/ run_sdmbench_chaos_pas/ run_sdmbench_chaos_pas_v 4_27.04.2026.py - preprocessing/
risperidone/ , Python, 265 linesspatial-cluster-stabilit y/ run_sdmbench_chaos_pas/ run_sdmbench_chaos_pas_v 5_27.04.2026.py - preprocessing/
risperidone/ , Python, 230 linesspatial-cluster-stabilit y/ run_sdmbench_chaos_pas/ run_sdmbench_chaos_pas_v 6_27.04.2026.py - preprocessing/
risperidone/ , Python, 439 linesspatial-cluster-stabilit y/ run_silhouette_analysis/ run_resolution_compare_0 .4_vs_0.85_FAST_v1_27.04 .2026.py - preprocessing/
risperidone/ , Python, 128 linesspatial-cluster-stabilit y/ run_silhouette_analysis/ run_silhouette_analysis_ v1_27.04.2026.py - preprocessing/
risperidone/ , Python, 148 linesspatial-cluster-stabilit y/ run_silhouette_analysis/ run_silhouette_analysis_ v2_27.04.2026.py - preprocessing/
risperidone/ , Python, 152 linesspatial-cluster-stabilit y/ run_silhouette_analysis/ run_silhouette_analysis_ v3_27.04.2026.py - preprocessing/
risperidone/ , Python, 160 linesspatial-cluster-stabilit y/ run_silhouette_analysis/ run_silhouette_analysis_ v4_27.04.2026.py - preprocessing/
risperidone/ , Python, 166 linesspatial-cluster-stabilit y/ run_silhouette_analysis/ run_silhouette_analysis_ v5_27.04.2026.py - preprocessing/
risperidone/ , Python, 255 linesspatial-cluster-stabilit y/ run_silhouette_analysis/ run_silhouette_analysis_ v6_27.04.2026.py - preprocessing/
risperidone/ , Python, 221 linesspatial-cluster-stabilit y/ run_silhouette_analysis/ run_silhouette_analysis_ v7_27.04.2026.py - preprocessing/
risperidone/ , Python, 267 linesspatial-cluster-stabilit y/ run_silhouette_analysis/ run_silhouette_analysis_ v8_27.04.2026.py - preprocessing/
risperidone/ , Python, 322 linesspatial-cluster-stabilit y/ run_silhouette_analysis/ run_silhouette_analysis_ v9_27.04.2026.py - preprocessing/
risperidone/ , R, 121 linesspatial-cluster-stabilit y/ sandbox/ ris-spatial-cluster-stab ility_v1_27.04.2026.R - preprocessing/
risperidone/ , R, 38 linesspatial-cluster-stabilit y/ sandbox/ ris-spatial-cluster-stab ility_v2_27.04.2026.R - preprocessing/
risperidone/ , R, 101 linesspatial-cluster-stabilit y/ sandbox/ ris-spatial-cluster-stab ility_v3_08.05.2026.R - preprocessing/
shiny-app/ , R, 66 linesclusters-testing.R - preprocessing/
shiny-app/ , R, 46 linesdebugging-shiny-external .R - preprocessing/
shiny-app/ , R, 45 linesdebugging-shiny-inner.R - preprocessing/
shiny-app/ , R, 94 linesshiny-app-plot-test1.R - preprocessing/
shiny-app/ , R, 64 linesshiny-app-plot-test2.R - preprocessing/
shiny-app/ , R, 48 linesshiny-app-plot-test3.R - preprocessing/
shiny-app/ , R, 78 linesshiny-app-plot-test4.R - preprocessing/
shiny-app/ , R, 326 linesshiny-app-spatial5.R - preprocessing/
shiny-app/ , R, 319 linesshiny-app-spatial6.R - preprocessing/
shiny-app/ , R, 384 linesshiny-app-spatial7.R - preprocessing/
shiny-app/ , R, 539 linesshiny-app-spatial8.R - preprocessing/
shiny-app/ , R, 660 linesshiny-app-spatial9.R - preprocessing/
shiny-app/ , R, 79 linesshiny-app-test1.R - preprocessing/
shiny-app/ , R, 118 linesshiny-app-test2.R - preprocessing/
shiny-app/ , R, 232 linesshiny-app-test3.R - preprocessing/
shiny-app/ , R, 296 linesshiny-app-test4.R - preprocessing/
shiny-app/ , R, 312 linesshiny-spatial-external1. R - preprocessing/
shiny-app/ , R, 380 linesshiny-spatial-external2. R - preprocessing/
shiny-app/ , R, 523 linesshiny-spatial-external3. R - preprocessing/
shiny-app/ , R, 32 linesshiny-test-docker1.R - preprocessing/
shiny-app/ , R, 84 linesspatial-browser-v2.0-dev / spatial-browser-v2.0.1.R - preprocessing/
shiny-app/ , R, 923 linesspatial-browser-v2.0-dev / spatial-browser-v2.0.10. R - preprocessing/
shiny-app/ , R, 997 linesspatial-browser-v2.0-dev / spatial-browser-v2.0.11. R - preprocessing/
shiny-app/ , R, 163 linesspatial-browser-v2.0-dev / spatial-browser-v2.0.2.R - preprocessing/
shiny-app/ , R, 175 linesspatial-browser-v2.0-dev / spatial-browser-v2.0.3.R - preprocessing/
shiny-app/ , R, 218 linesspatial-browser-v2.0-dev / spatial-browser-v2.0.4.R - preprocessing/
shiny-app/ , R, 448 linesspatial-browser-v2.0-dev / spatial-browser-v2.0.5.R - preprocessing/
shiny-app/ , R, 457 linesspatial-browser-v2.0-dev / spatial-browser-v2.0.6.R - preprocessing/
shiny-app/ , R, 896 linesspatial-browser-v2.0-dev / spatial-browser-v2.0.8.R - preprocessing/
shiny-app/ , R, 671 linesspatial-browser-v2.0-dev / spatial-browser-v2.0.9.R - preprocessing/
shiny-app/ , R, 1,189 linesspatial-browser-v2.0-dev / spatial-browser-v2.1.0.R - preprocessing/
shiny-app/ , R, 815 linesspatial-browser-v2.0-dev / sptial-browser-v2.0.7.R - preprocessing/
shiny-app/ , R, 12 linesspatial-browser-v2.1-dep loy/ app.R - preprocessing/
shiny-app/ , R, 71 linesspatial-browser-v2.1-dep loy/ global.R - preprocessing/
shiny-app/ , R, 589 linesspatial-browser-v2.1-dep loy/ server.R - preprocessing/
shiny-app/ , R, 360 linesspatial-browser-v2.1-dep loy/ ui.R - preprocessing/
shiny-app/ , R, 12 linesspatial-browser-v2.2-dep loy/ app.R - preprocessing/
shiny-app/ , R, 158 linesspatial-browser-v2.2-dep loy/ global.R - preprocessing/
shiny-app/ , R, 752 linesspatial-browser-v2.2-dep loy/ server.R - preprocessing/
shiny-app/ , R, 421 linesspatial-browser-v2.2-dep loy/ ui.R - preprocessing/
shiny-app/ , R, 12 linesspatial-transcriptomics- drug-browser1/ app.R - preprocessing/
shiny-app/ , R, 16 linesspatial-transcriptomics- drug-browser1/ global.R - preprocessing/
shiny-app/ , R, 395 linesspatial-transcriptomics- drug-browser1/ server.R - preprocessing/
shiny-app/ , R, 146 linesspatial-transcriptomics- drug-browser1/ ui.R - preprocessing/
shiny-app/ , R, 12 linesspatial-transcriptomics- drug-browser2/ app.R - preprocessing/
shiny-app/ , R, 17 linesspatial-transcriptomics- drug-browser2/ global.R - preprocessing/
shiny-app/ , R, 455 linesspatial-transcriptomics- drug-browser2/ server.R - preprocessing/
shiny-app/ , R, 178 linesspatial-transcriptomics- drug-browser2/ ui.R - preprocessing/
shiny-app/ , R, 12 linesspatial-transcriptomics- drug-browser3/ app.R - preprocessing/
shiny-app/ , R, 18 linesspatial-transcriptomics- drug-browser3/ global.R - preprocessing/
shiny-app/ , R, 530 linesspatial-transcriptomics- drug-browser3/ server.R - preprocessing/
shiny-app/ , R, 189 linesspatial-transcriptomics- drug-browser3/ ui.R - preprocessing/
shiny-app/ , R, 12 linesspatial-transcriptomics- drug-browser4/ app.R - preprocessing/
shiny-app/ , R, 20 linesspatial-transcriptomics- drug-browser4/ global.R - preprocessing/
shiny-app/ , R, 554 linesspatial-transcriptomics- drug-browser4/ server.R - preprocessing/
shiny-app/ , R, 206 linesspatial-transcriptomics- drug-browser4/ ui.R - preprocessing/
spaceranger-analysis-v1. , Shell, 158 lines1.sh - preprocessing/
spaceranger-analysis-v2. , Shell, 102 linessh - preprocessing/
spaceranger-analysis.sh , Shell, 103 lines - preprocessing/
spaceranger-analysis2.sh , Shell, 106 lines - preprocessing/
tested-scripts/ , R, 283 linesdevelopment-statistics.R - preprocessing/
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tested-scripts/ , R, 55 linestest.r - preprocessing/
tested-scripts/ , R, 110 linesvisualization-seurat.R - preprocessing/
to-remove/ , R, 143 linesanalysis-data-normalize. R - preprocessing/
to-remove/ , R, 118 linesanalysis-data-seurat.R - preprocessing/
to-remove/ , R, 137 linespreparation-visualizatio n.R - preprocessing/
to-remove/ , R, 73 linesread-data.R - README.md, Text, 91 lines
Tracing map
Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.
What the map holds:
- 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
- 349 scripts, each with its path and the digest of its content;
- 7 matches between paragraphs of the paper and lines of the code (method lexical-v1);
- neither the text of the paper nor the code itself.
Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.
Data
No dataset and no data link were found in the paper.
Data availability statement
The RNAseq dataset generated for this study can be found in the Sequence Read Archive, https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 9 authors, 7 keywords, 79 references, 9 RRIDs.
Cite
This paper
Ziemiańska, M., Zięba, M., Radlicka-Borysewska, A., Szumiec, Ł., Gołda, S., Borczyk, M., Piechota, M., Korostyński, M., & Rodriguez Parkitna, J. (2026). Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice. Frontiers in molecular neuroscience, 19, 1844705. https://
BibTeX
@article{ziemianska2026r
author = {Ziemiańska, Magdalena and Zięba, Mateusz and Radlicka-Borysewska, Anna and Szumiec, Łukasz and Gołda, Sławomir and Borczyk, Małgorzata and Piechota, Marcin and Korostyński, Michał and Rodriguez Parkitna, Jan},
title = {{Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice}},
journal = {Frontiers in molecular neuroscience},
year = {2026},
month = may,
volume = {19},
pages = {1844705},
publisher = {Frontiers Media SA},
issn = {1662-5099},
doi = {10.3389/
url = {https://
pmid = {42293048},
pmcid = {PMC13260059}
}
RIS
TY - JOUR
AU - Ziemiańska, Magdalena
AU - Zięba, Mateusz
AU - Radlicka-Borysewska, Anna
AU - Szumiec, Łukasz
AU - Gołda, Sławomir
AU - Borczyk, Małgorzata
AU - Piechota, Marcin
AU - Korostyński, Michał
AU - Rodriguez Parkitna, Jan
TI - Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice
T2 - Frontiers in molecular neuroscience
J2 - Front Mol Neurosci
PY - 2026
DA - 2026/
VL - 19
SP - 1844705
SN - 1662-5099
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.3389/
"type": "article-journal",
"title": "Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice",
"container-title": "Frontiers in molecular neuroscience",
"author": [
{
"family": "Ziemiańska",
"given": "Magdalena"
},
{
"family": "Zięba",
"given": "Mateusz"
},
{
"family": "Radlicka-Borysewska",
"given": "Anna"
},
{
"family": "Szumiec",
"given": "Łukasz"
},
{
"family": "Gołda",
"given": "Sławomir"
},
{
"family": "Borczyk",
"given": "Małgorzata"
},
{
"family": "Piechota",
"given": "Marcin"
},
{
"family": "Korostyński",
"given": "Michał"
},
{
"family": "Rodriguez Parkitna",
"given": "Jan"
}
],
"container-title-short":
"volume": "19",
"page": "1844705",
"DOI": "10.3389/
"PMID": "42293048",
"PMCID": "PMC13260059",
"ISSN": "1662-5099",
"publisher": "Frontiers Media SA",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
29
]
]
}
}
The tracing map gets a citation of its own once an author has validated it and it has a DOI.
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