Diminished Maternal Tryptophan Leads to Sexually Dimorphic Differences in the Placenta-Brain Axis.
Overview
13 affiliations
- Pathobiology and Integrative Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA; (R.T.B.H.); (S.E.S.); (E.E.B.)
- Biological Sciences, University of Missouri, Columbia, MO 65211, USA
- Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25703, USA; (Z.L.); (T.J.)
- Christopher S. Bond Life Science Center, University of Missouri, Columbia, MO 65211, USA; (Z.L.); (L.W.S.)
- Animal Sciences, University of Missouri, Columbia, MO 65211, USA
- Obstetrics, Gynecology, and Women’s Health, University of Missouri, Columbia, MO 65211, USA
- Genomics Technology Core Facility, University of Missouri, Columbia, MO 65211, USA
- University of Missouri Metabolomics Center, University of Missouri, Columbia, MO 65211, USA
- Division of Biochemistry, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, MO 65211, USA
- Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65201, USA
- MU Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, USA
- Department of Genetics Area Program, University of Missouri, Columbia, MO 65211, USA
- Department of Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, MO 65211, USA
Abstract
Background: Tryptophan (Trp) is critical to mothers and their conceptuses, and this amino acid is the precursor to serotonin (5-HT). 5-HT modulates placenta function and fetal neurodevelopment. It is not clear if the placenta directly synthesizes 5-HT or uses the serotonin transporter (SERT/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- geo:GSE330442, at NCBI GEO; found in “Data Availability Statement”
Data Availability Statement
RNA sequencing data have been deposited and are publicly available in the Gene Expression Omnibus under accession: GSE330442 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 7 keywords, 14 MeSH terms, 7 funders, 74 references.
Cite
This paper
Herrington, R. T. B., Lyu, Z., Seda, S. E., Boling, E. E., Goldstein, A. K., Bivens, N. J., Lei, Z., Islam, T., Sumner, L. W., Joshi, T., & Rosenfeld, C. S. (2026). Diminished Maternal Tryptophan Leads to Sexually Dimorphic Differences in the Placenta-Brain Axis. Nutrients, 18(15), 2575. https://
BibTeX
@article{herrington2026d
author = {Herrington, Rosalind T B and Lyu, Zhen and Seda, Sarah E and Boling, Emmett E and Goldstein, Andrea K and Bivens, Nathan J and Lei, Zhentian and Islam, Tanhaul and Sumner, Lloyd W and Joshi, Trupti and Rosenfeld, Cheryl S},
title = {{Diminished Maternal Tryptophan Leads to Sexually Dimorphic Differences in the Placenta-Brain Axis}},
journal = {Nutrients},
year = {2026},
month = aug,
volume = {18},
number = {15},
pages = {2575},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {2072-6643},
doi = {10.3390/
url = {https://
pmid = {42588198},
pmcid = {PMC13468233}
}
RIS
TY - JOUR
AU - Herrington, Rosalind T B
AU - Lyu, Zhen
AU - Seda, Sarah E
AU - Boling, Emmett E
AU - Goldstein, Andrea K
AU - Bivens, Nathan J
AU - Lei, Zhentian
AU - Islam, Tanhaul
AU - Sumner, Lloyd W
AU - Joshi, Trupti
AU - Rosenfeld, Cheryl S
TI - Diminished Maternal Tryptophan Leads to Sexually Dimorphic Differences in the Placenta-Brain Axis
T2 - Nutrients
J2 - Nutrients
PY - 2026
DA - 2026/
VL - 18
IS - 15
SP - 2575
SN - 2072-6643
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/
UR - https://
LA - en
ER -
CSL-JSON
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