Susceptibility of the Placenta and Fetal Brain to Maternal Probiotic Supplementation.
Overview
- Pathobiology and Integrative Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA; (R.T.B.H.); (D.T.E.)
- Biological Sciences, University of Missouri, Columbia, MO 65211, USA
- Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25703, USA
- Christopher S. Bond Life Science Center, University of Missouri, Columbia, MO 65211, USA
- Genomics Technology Core Facility, University of Missouri, Columbia, MO 65211, USA
- University of Missouri Metabolomics Center, University of Missouri, Columbia, MO 65211, USA; (Z.L.); (T.I.); (L.W.S.)
- Biochemistry, University of Missouri, Columbia, MO 65211, USA
- Animal Sciences, University of Missouri, Columbia, MO 65211, USA
- Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65201, USA
- MU Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, USA
- Department of Genetics Area Program, University of Missouri, Columbia, MO 65211, USA
- Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, MO 65211, USA
Abstract
Probiotic supplements are increasingly being touted to have health benefits for pregnant women consuming such supplements and their unborn offspring. The placenta is in direct communication with maternal blood, and bioactive agents can thus easily be transferred to this organ where they may influence gene expression by the different trophoblast (TB) cell lineages. The underlying hypothesis assessed herein is that maternal probiotic supplementation can influence the placenta and fetal brain. The composition of bacterial short-chain fatty acids (SCFAs) was examined in fecal boli of mouse dams on a maternal probiotic supplement relative to control dams. Further, SCFA and transcriptomic profiles were examined in placenta and fetal brain from conceptuses derived from dams on the probiotic supplement and conceptuses from control dams. While this treatment did not affect bacterial SCFAs, placenta and fetal brain changes were evident in male and female conceptuses carried by dams receiving probiotics relative to controls. For the placenta, females were more sensitive to maternal probiotic supplementation, whereas the opposite was the case for the fetal brain. Slc6a4 showed increased expression in female placenta from probiotic-treated dams, which could enhance uptake of maternal 5-HT. Male placenta from probiotic-treated dams had dramatic reduction in Hsd11b2 that may render them more vulnerable to maternal stress. In the fetal brain, maternal probiotic supplementation was associated with genes linked to forebrain development, suggesting this treatment might impact life-long neurobehavioral responses. Current studies suggest that maternal probiotic supplementation might lead to adverse changes in the placenta and fetal brain of their unborn children.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- geo:GSE309308, at NCBI GEO; found in “2.12. Data Availability”
2.12. Data Availability
RNA sequencing data have been deposited in the Gene Expression Omnibus under accession: GSE309308 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Data Availability Statement
The RNA sequencing data presented in this study are openly available in the Gene Expression Omnibus under accession: GSE309308 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 8 keywords, 6 funders, 105 references.
Cite
This paper
Herrington, R. T. B., Lyu, Z., Ellenberger, D. T., Bivens, N. J., Lei, Z., Islam, T., Sumner, L. W., Roberts, R. M., Joshi, T., & Rosenfeld, C. S. (2026). Susceptibility of the Placenta and Fetal Brain to Maternal Probiotic Supplementation. Microorganisms, 14(6), 1175. https://
BibTeX
@article{herrington2026s
author = {Herrington, Rosalind T. B. and Lyu, Zhen and Ellenberger, David T. and Bivens, Nathan J. and Lei, Zhentian and Islam, Tanhaul and Sumner, Lloyd W. and Roberts, R. Michael and Joshi, Trupti and Rosenfeld, Cheryl S.},
title = {{Susceptibility of the Placenta and Fetal Brain to Maternal Probiotic Supplementation}},
journal = {Microorganisms},
year = {2026},
month = may,
volume = {14},
number = {6},
pages = {1175},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {2076-2607},
doi = {10.3390/
url = {https://
pmid = {42354800},
pmcid = {PMC13303452}
}
RIS
TY - JOUR
AU - Herrington, Rosalind T. B.
AU - Lyu, Zhen
AU - Ellenberger, David T.
AU - Bivens, Nathan J.
AU - Lei, Zhentian
AU - Islam, Tanhaul
AU - Sumner, Lloyd W.
AU - Roberts, R. Michael
AU - Joshi, Trupti
AU - Rosenfeld, Cheryl S.
TI - Susceptibility of the Placenta and Fetal Brain to Maternal Probiotic Supplementation
T2 - Microorganisms
J2 - Microorganisms
PY - 2026
DA - 2026/
VL - 14
IS - 6
SP - 1175
SN - 2076-2607
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/
UR - https://
LA - en
ER -
CSL-JSON
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