Glial Scar-Targeted Modification of Hepatocyte Growth Factor-Derived Peptide for Spinal Cord Injury Therapeutic Repair.
Overview
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China
- Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo 315300, China
- The First Clinical Medical College (School of Information and Engineering), Wenzhou Medical University, Wenzhou 325035, China
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou 325027, China
- Department of Orthopaedics, Tangdu Hospital, The Air Force Medical University, Xi’an 710038, China
- School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325000, China
- Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
- Department of Orthopedics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
- Department of Wound Repair, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
- Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China
- Department of Laboratory Medicine, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu 241001, China
Abstract
Spinal cord injury (SCI) causes irreversible neural damage and functional impairment. H-RN is a short peptide originating from the kringle 1 domain of hepatocyte growth factor. Despite its efficacy in inhibiting inflammatory responses, the precise neuroprotective mechanisms of the peptide H-RN in SCI remain unclear. The short peptide CAQK can target the lesion epicenter of SCI. To explore the role of the peptide H-RN in SCI and address the numerous challenges faced by conventional drug therapies, this study developed a synthetic peptide, CAQK-H-RN. Our results revealed that CAQK-H-RN could cross the blood–spinal cord barrier, precisely target the SCI region, and increase drug accumulation at the injury site, thereby reducing glial scar formation, decreasing motor neuron death, and enhancing functional recovery after SCI. RNA sequencing was performed to explore the molecular mechanisms of CAQK-H-RN in SCI, which revealed that CAQK-H-RN inhibited pyroptosis and ameliorated lysosomal membrane permeabilization (LMP)-induced autophagic flux disorders in neurons after SCI. Additionally, CAQK-H-RN alleviated LMP by suppressing acid sphingomyelinase activity through the p38 mitogen-activated protein kinase/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- geo:GSE172167, at NCBI GEO; found in the text, “Single-nucleus RNA sequencing analysis”
Data Availability
The data that support the findings of this study are available from the corresponding authors upon reasonable request.
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Versions
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Version 1, 30 October 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 21 authors, 1 funder, 48 references.
Cite
This paper
Wu, Y., Shi, J., Miao, R., Xiang, L., Zhang, J., Chi, W., Zhang, Y., Geng, Y., Cai, X., Shu, Y., Zhao, J., Zhu, J., Jiang, X., Zhang, H., Li, Z., Wang, X., Sheng, S., Zhu, C., Qi, J., . . . Zhou, K. (2026). Glial Scar-Targeted Modification of Hepatocyte Growth Factor-Derived Peptide for Spinal Cord Injury Therapeutic Repair. Biomaterials research, 30, 0431. https://
BibTeX
@article{wu2026glial,
author = {Wu, Yuzhe and Shi, Jingwei and Miao, Ruize and Xiang, Linyi and Zhang, Jiacheng and Chi, Weiyi and Zhang, Yuheng and Geng, Yibo and Cai, Xiong and Shu, Yun and Zhao, Jiayi and Zhu, Junsheng and Jiang, Xiaoqiong and Zhang, Haojie and Li, Zhenglin and Wang, Xiangyang and Sheng, Sunren and Zhu, Chenchen and Qi, Jianjun and Xiao, Jian and Zhou, Kailiang},
title = {{Glial Scar-Targeted Modification of Hepatocyte Growth Factor-Derived Peptide for Spinal Cord Injury Therapeutic Repair}},
journal = {Biomaterials research},
year = {2026},
month = oct,
volume = {30},
pages = {0431},
publisher = {AAAS Science Partner Journal Program},
issn = {1226-4601},
doi = {10.34133/
url = {https://
pmid = {42947949},
pmcid = {PMC13710766}
}
RIS
TY - JOUR
AU - Wu, Yuzhe
AU - Shi, Jingwei
AU - Miao, Ruize
AU - Xiang, Linyi
AU - Zhang, Jiacheng
AU - Chi, Weiyi
AU - Zhang, Yuheng
AU - Geng, Yibo
AU - Cai, Xiong
AU - Shu, Yun
AU - Zhao, Jiayi
AU - Zhu, Junsheng
AU - Jiang, Xiaoqiong
AU - Zhang, Haojie
AU - Li, Zhenglin
AU - Wang, Xiangyang
AU - Sheng, Sunren
AU - Zhu, Chenchen
AU - Qi, Jianjun
AU - Xiao, Jian
AU - Zhou, Kailiang
TI - Glial Scar-Targeted Modification of Hepatocyte Growth Factor-Derived Peptide for Spinal Cord Injury Therapeutic Repair
T2 - Biomaterials research
J2 - Biomater Res
PY - 2026
DA - 2026/
VL - 30
SP - 0431
SN - 1226-4601
PB - AAAS Science Partner Journal Program
DO - 10.34133/
UR - https://
LA - en
ER -
CSL-JSON
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