OSCR

Mesoscale functional architecture in medial posterior parietal cortex.

Code ↔ Paper

The paper beside its authors' code: matches between them have not been computed for this paper yet.

Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

The paper is loaded when this pane is shown.

The authors' code

License · 21 lines · 1 KB · MIT

  1. MIT License
  3. Copyright (c) 2026 Riichiro Hira
  5. Permission is hereby granted, free of charge, to any person obtaining a copy
  6. of this software and associated documentation files (the "Software"), to deal
  7. in the Software without restriction, including without limitation the rights
  8. to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
  9. copies of the Software, and to permit persons to whom the Software is
  10. furnished to do so, subject to the following conditions:
  12. The above copyright notice and this permission notice shall be included in all
  13. copies or substantial portions of the Software.
  15. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
  16. IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
  17. FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
  18. AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
  19. LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
  20. OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
  21. SOFTWARE.

LICENSE at commit 3b2ca6a, under MIT · at the source

Overview

Authors: Riichiro Hira1,2,3, Leah B Townsend2, Ikuko T Smith4, Che-Hang Yu1, Jeffery N Stirman2, Yiyi Yu1, Spencer LaVere Smith1,2
ORCID iDs: Riichiro Hira, Ikuko T Smith, Yiyi Yu, Spencer LaVere Smith
  1. Department of Electrical and Computer Engineering, University of California, Santa Barbara, Santa Barbara, United States
  2. Neuroscience Center, University of North Carolina Chapel Hill, Chapel Hill, United States
  3. Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan
  4. Department of Molecular, Cellular, and Developmental Biology, Department of Psychology and Brain Sciences, University of California, Santa Barbara, Santa Barbara, United States
Institutions: University of North Carolina at Chapel Hill (United States); Tokyo Medical and Dental University (Japan); University of California, Santa Barbara (United States)
Journal: eLife, volume 14, article RP105213
Dates: published online 2 September 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.7554/elife.105213 · PMID 42684331 · PMCID PMC13537763 · OpenAlex W4407253325
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: mouse (organism), cognitive (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Preprocessing, fMRI & imaging, Single-unit activity, calcium imaging, Physiology & signal measures
Keywords: Mouse
MeSH: Neurons*, Parietal Lobe*, Animals, Male, Mice, Mice, Inbred C57BL, Visual Cortex, Visual Perception (* major topic)
Topic: Neural dynamics and brain function (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: National Institute of Health (NINDS R01NS091335); National Science Foundation (NeuroNex 1934288, BRAIN EAGER 1450824); Japan Society for the Promotion of Science (JP21B304, JP21H05134, JP21H05135); NIH HHS (R01NS121919, R01NS128079, R01EY024294, R01EY035378); Japan Science and Technology Agency (JP22H02731); NINDS NIH HHS (R01 NS091335, R01 NS121919, R01 NS128079); Iran National Science Foundation (1707287); NEI NIH HHS (R01 EY024294, R01 EY035378); Japan Agency for Medical Research and Development (JP22wm0525007)
Citations: cited by 2 papers (Europe PMC); 91 references in the paper

Abstract

The posterior parietal cortex (PPC) in mice has various functions, including multisensory integration, vision-guided behaviors, working memory, and posture control. However, an integrated understanding of these functions and their cortical localizations in and around the PPC and higher visual areas (HVAs) has not been completely elucidated. Here, we simultaneously imaged the activity of thousands of neurons within a 3 × 3 mm2 field of view, including eight cortical areas around the PPC, during behavior with a two-photon mesoscope. Mice performed both a vision-guided task and a choice history-dependent task, and the imaging results revealed distinct, localized, and behavior-related functions of two medial PPC areas. Neurons in the anteromedial (AM) HVA responded to both vision and choice information, and thus AM is a locus of association between these channels. By contrast, the anterior (A) HVA stores choice history with sequential dynamics and represents posture. Mesoscale correlation analysis on the intertrial variability of neuronal activity demonstrated that neurons in AM exhibited diverse, area-dependent interactions, while neurons in area A shared fluctuations with the primary somatosensory area. Pairwise interareal interactions among neurons were precisely predicted by the anatomical input correlations, with the exception of some global interactions. Thus, the medial PPC has two distinct modules, areas AM and A, with each having distinctive modes of cortical communication. These medial PPC modules can serve separate higher-order functions: area AM for multisensory and cognitive integration with locally processed signals and area A for transmission of information including posture, movement, and working memory.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repositories

Its files are read in the Code ↔ Paper reader above.

web.ece.ucsb.edu/~riichirohira/topbm-2.05

License: none: the authors keep all their rights
State: the link answers, verified on 26 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 26 September 2026: the link answers (HTTP 200)
  • 26 September 2026: the link answers (HTTP 200)
At the source: web.ece.ucsb.edu/~riichirohira/TopBM-2.05/index.html

riichirohira/BrainModules

License: MIT
State: the link answers, verified on 26 September 2026
Evidence: files inventoried
Commit: 3b2ca6aeabc107cb29cd153c29637c2bbb1dec92, 2 September 2026
Size: 2 files, 0 scripts
Software Heritage: not archived
Found in: “Code availability”
Holds: README, license file
Not found: CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 26 September 2026: the link answers
  • 26 September 2026: the link answers
2 files
At the source: github.com/riichirohira/BrainModules

Code availability

A web-based interactive software including its source code is available online (https://web.ece.ucsb.edu/~riichirohira/TopBM-2.05/index.html). The script for the data analysis is available on GitHub (https://github.com/riichirohira/BrainModules, copy archived at Hira, 2026).

Reproduced under the paper's license (CC BY), from the paper cited above.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Data availability

The two-photon calcium imaging data have been made publicly available on figshare https://doi.org/10.6084/m9.figshare.33106817.

The following dataset was generated:

Hira R. 2026. Mesoscale functional architecture in medial posterior parietal cortex. figshare.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 7 authors, 1 keyword, 8 MeSH terms, 9 funders, 88 references.

Cite

This paper

Hira, R., Townsend, L. B., Smith, I. T., Yu, C.-H., Stirman, J. N., Yu, Y., & Smith, S. L. (2026). Mesoscale functional architecture in medial posterior parietal cortex. eLife, 14, RP105213. https://doi.org/10.7554/elife.105213

BibTeX

@article{hira2026mesoscale,
author = {Hira, Riichiro and Townsend, Leah B and Smith, Ikuko T and Yu, Che-Hang and Stirman, Jeffery N and Yu, Yiyi and Smith, Spencer LaVere},
title = {{Mesoscale functional architecture in medial posterior parietal cortex}},
journal = {eLife},
year = {2026},
month = sep,
volume = {14},
pages = {RP105213},
publisher = {eLife Sciences Publications, Ltd},
issn = {2050-084X},
doi = {10.7554/elife.105213},
url = {https://doi.org/10.7554/elife.105213},
pmid = {42684331},
pmcid = {PMC13537763}
}

RIS

TY - JOUR
AU - Hira, Riichiro
AU - Townsend, Leah B
AU - Smith, Ikuko T
AU - Yu, Che-Hang
AU - Stirman, Jeffery N
AU - Yu, Yiyi
AU - Smith, Spencer LaVere
TI - Mesoscale functional architecture in medial posterior parietal cortex
T2 - eLife
J2 - eLife
PY - 2026
DA - 2026/09/02
VL - 14
SP - RP105213
SN - 2050-084X
PB - eLife Sciences Publications, Ltd
DO - 10.7554/elife.105213
UR - https://doi.org/10.7554/elife.105213
LA - en
ER -

CSL-JSON

{
"id": "10.7554/elife.105213",
"type": "article-journal",
"title": "Mesoscale functional architecture in medial posterior parietal cortex",
"container-title": "eLife",
"author": [
{
"family": "Hira",
"given": "Riichiro"
},
{
"family": "Townsend",
"given": "Leah B"
},
{
"family": "Smith",
"given": "Ikuko T"
},
{
"family": "Yu",
"given": "Che-Hang"
},
{
"family": "Stirman",
"given": "Jeffery N"
},
{
"family": "Yu",
"given": "Yiyi"
},
{
"family": "Smith",
"given": "Spencer LaVere"
}
],
"container-title-short": "eLife",
"volume": "14",
"page": "RP105213",
"DOI": "10.7554/elife.105213",
"PMID": "42684331",
"PMCID": "PMC13537763",
"ISSN": "2050-084X",
"publisher": "eLife Sciences Publications, Ltd",
"URL": "https://doi.org/10.7554/elife.105213",
"language": "en",
"issued": {
"date-parts": [
[
2026,
9,
2
]
]
}
}

The tracing map gets a citation of its own once an author has validated it and it has a DOI.

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s41467-026-73999-w [code]
Independence and coherence in temporal sequence computation across the fronto-parietal network.
Journal: Nature communications
In common: mouse, 12 references, author Riichiro Hira
[2] doi:10.1016/j.neuron.2026.07.016 [code]
Inferring brain-wide interactions using data-constrained recurrent neural network models.
Journal: Neuron
In common: mouse, 9 references
[3] doi:10.1126/sciadv.aef3715
A cortical output channel for perceptual categorization.
Journal: Science advances
In common: cognitive, mouse, 7 references
[4] doi:10.1016/j.isci.2026.117187 [code]
Functional and structural characterization of dendritic spine pathology in a mouse model of tauopathy.
Journal: iScience
In common: mouse, 4 references, author Ikuko T Smith
[5] doi:10.1038/s41592-026-03125-7
Simultaneous two- and three-photon multiplane imaging across cortical layers in freely moving mice.
Journal: Nature methods
In common: mouse, 6 references
[6] doi:10.7554/elife.109240 [code]
Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex.
Journal: eLife
In common: mouse, 6 references
[7] doi:10.1126/sciadv.adz6495
Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.
Journal: Science advances
In common: mouse, 5 references
[8] doi: [code]
Real-time closed-loop feedback system for mouse mesoscale cortical signal and movement control
Journal: eLife
In common: mouse, 5 references
[9] doi:10.1038/s41467-026-73622-y [code]
Contextual gating of whisker-evoked responses by frontal cortex supports flexible decision making.
Journal: Nature communications
In common: cognitive, mouse, 5 references
[10] doi:10.1371/journal.pone.0356243 [code]
Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds.
Journal: PloS one
In common: mouse, 4 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.