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Visual information is broadcast among cortical areas in discrete channels.

Code ↔ Paper

4 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 4 matches
  1. [1] § Results › Functional connectivity is stable across stimuli ↔ NSC_compare.m, lines 274 to 342 · score 0.62 · linear predictor, error bars, naturalistic video, Variance explained, model, grating · Report a mismatch
  2. [2] § Materials and methods › Decompose neural activity ↔ FR_pupilAna.m, lines 37 to 161 · score 0.58 · pupil dynamics, ordinary regression, prediction, video, model, variance · Report a mismatch
  3. [3] § Materials and methods › Decompose neural activity ↔ FR_pupilAna.m, lines 37 to 161 · score 0.58 · pupil dynamics, residual population, subtracting, regression, model, stimulus · Report a mismatch
  4. [4] § Results › Tuning similarity is a major factor in the V1-HVA functional network ↔ NSCmean_vsDist.m, lines 354 to 452 · score 0.55 · error bar, neuron distance, signal correlation, FR, V1 · Report a mismatch

Paper

Loaded from Europe PMC by your browser; OSCR does not store it: doi.org · Europe PMC

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The authors' code

MATLAB · 263 lines · 11 KB · GPL-3.0 · 2 matches

  1. load('pooldata_SinGrat.mat', 'pooldata','name1','areaID')
  2. load('pooldata_pupiltrack.mat')
  3. Dir = [0, 135, 270, 45, 180, 315, 90, 225];
  4. [DirSort, DirInd] = sort(Dir);
  5. stimPara = ...
  6. [8 0.16;
  7. 2 0.02;
  8. 8 0.02;
  9. 1 0.02;
  10. 1 0.16;
  11. 2 0.16;
  12. 8 0.04;
  13. 2 0.04;
  14. 1 0.04];
  15. stimflag = [repmat(Dir',9,1)/360*2*pi, reshape(repmat(stimPara(:,1),1,8)',[],1),...
  16. reshape(repmat(stimPara(:,2),1,8)',[],1)];
  17. [stimsort, stimInd] = sortrows(stimPara, [1 2]);
  18. TmFreq = [1,2,8];
  19. SpFreq = [0.02, 0.04, 0.16];
  20. % TmFreq = stimsort(:,1);
  21. % SpFreq = stimsort(:,2);
  22. Twindow = [0 2 4 6 8 10 12 14 16]; % s
  23. delay = 0;
  24. DirSortVect = [0 1; -sqrt(2)/2 sqrt(2)/2; -1 0;-sqrt(2)/2 -sqrt(2)/2; 0 -1;sqrt(2)/2 -sqrt(2)/2; 1 0;sqrt(2)/2 sqrt(2)/2];
  25. %%
  26. Npc = [];
  27. for k1 = 1:length(poolpupildata)
  28. if ~isempty(poolpupildata(k1).pupildata)
  29. pupildata = poolpupildata(k1).pupildata;
  30. if isfield(pupildata, 'pupilsync')
  31. Npc(k1,1) = pupildata.video_PCdim;
  32. Npc(k1,2) = pupildata.video_PCvar;
  33. end
  34. end
  35. end
  36. %%
  37. binWidth = 100;
  38. smoothSD = 2;
  39. popResp_var = [];
  40. for k1 = 1:length(poolpupildata)
  41. if ~isempty(poolpupildata(k1).pupildata)
  42. pupildata = poolpupildata(k1).pupildata;
  43. if isfield(pupildata, 'pupilsync')
  44. pupilsync = pupildata.pupilsync;
  45. sync2p = table2array(poolpupildata(k1).sync2p);
  46. l0 = find(pupilsync(:,3)==1,1);
  47. l1 = find(pupilsync(:,3)==1,1,'last');
  48. pupildyn = [pupildata.eyearea(l0:l1)',pupildata.eyecenter(l0:l1,:),pupildata.videoscore];
  49. pupildyn(pupildyn(:,1)==0,1:3) = nan;
  50. pupilPC(k1,1:2) = [pupildata.video_PCdim, pupildata.video_PCvar];
  51. pupildyn_t = pupilsync(l0:l1,1:2);
  52. pupildyn_t = bsxfun(@minus, pupildyn_t, pupildyn_t(1,:))+1;
  53. pupildyn_match2p = [];
  54. for j = 1:size(pupildyn,2)
  55. tmp = interp1(pupildyn_t(:,1)/pupildyn_t(end,1), pupildyn(:,j), sync2p(:,1)/sync2p(end,1));
  56. pupildyn_match2p = cat(2, pupildyn_match2p, tmp);
  57. end
  58. imgPara = pooldata(k1,1).imgPara;
  59. % pupil dynamics bined per direction (2 sec window)
  60. pupildyn_bin = [];
  61. for i = 1:imgPara.stimrep
  62. for j = 1:imgPara.stim_type
  63. tmp = pupildyn_match2p(sync2p(:,3)==i & sync2p(:,5)==j,:);
  64. tmp1 = imresize(tmp, [8 size(tmp,2)]);
  65. pupildyn_bin = cat(1, pupildyn_bin, tmp1);
  66. end
  67. end
  68. X_pupildyn = pupildyn_bin;
  69. X_stim = repmat(stimflag, imgPara.stimrep, 1);
  70. for k2 = 1:4
  71. if ~isempty(pooldata(k1,k2).spiketrain) && length(pooldata(k1,k2).goodcell) > 5
  72. goodcell = pooldata(k1,k2).goodcell;
  73. spiketrain = pooldata(k1,k2).spiketrain(goodcell);
  74. num(k1,k2) = length(goodcell);
  75. spikecountAve = []; h = []; spikecountraw1 = [];
  76. spikecountraw2 = []; snr = [];
  77. for n = 1:length(goodcell)
  78. tmphist = [];
  79. stvec = [];
  80. for i = 1:imgPara.stimrep
  81. st1 = [];
  82. for j = 1:imgPara.stim_type
  83. st = spiketrain(n).st{i,j}*imgPara.dt;
  84. st(st<0) = [];
  85. st(st>imgPara.stim_time) = [];
  86. st1 = [st1, st+imgPara.stim_time*(j-1)];
  87. tmphist1 = histcounts(st, Twindow);
  88. tmphist = cat(1, tmphist, tmphist1');
  89. end
  90. stvec = vectCat(stvec, st1');
  91. end
  92. [rate , rateT] = myPSTH(stvec*1000, [0, imgPara.stim_time*imgPara.stim_type]*1000, binWidth, smoothSD);
  93. spikecountraw1(n,:) = tmphist;
  94. spikecountAve(n,:) = rate;
  95. end
  96. % total variance of population response
  97. Y = spikecountraw1';
  98. Y = bsxfun(@minus, Y, mean(Y,1));
  99. Y_totvar = var(Y(:));
  100. % variance explained by stimulus induced response
  101. Ym = mean(reshape(Y, 72,imgPara.stimrep,size(Y,2)), 2);
  102. Ym_var = var(Ym(:));
  103. Y_stimexp = Ym_var/Y_totvar;
  104. % residual population response after subtracting stimulus
  105. % induced portion (estimated by trial averaged response)
  106. Y = bsxfun(@minus, reshape(Y, 72,imgPara.stimrep,size(Y,2)), Ym);
  107. Y = reshape(Y,[],size(Y,3));
  108. Y_resvar = var(Y(:));
  109. % ordinary regression variance explained by pupil dynamics
  110. X = X_pupildyn;
  111. X(isnan(X)) = 0;
  112. % Bols = inv(X'*X)*X'*Y;
  113. % Yhat2 = X*Bols;
  114. % e = mean((Yhat2-Y).^2);
  115. % Y_pupildynexp_OLS = 1-mean(e./var(Y));
  116. e = []; d = [];
  117. for k = 1:size(X,2)
  118. [Br, Bols, e(k), d(k)] = RRR_bySVD(X, Y, k);
  119. end
  120. % Y_pupildynexp_RRR = 1 - min(e);
  121. [~, k] = min(e);
  122. [Br, Bols, ~, ~] = RRR_bySVD(X, Y, k);
  123. Yhat2 = X * Br;
  124. Y_pupildynexp_RRR = var(Yhat2(:))/Y_totvar;
  125. % residual network response factoring out pupil dynamics
  126. % correlated portion (graph model)
  127. Y_res = Y - Yhat2;
  128. r = []; ypred = [];
  129. for n = 1:size(Y,2)
  130. X = Y_res;
  131. X(:,n) = [];
  132. [c,s,l] = pca(X);
  133. pcscore = s(:,1:find(l<0.1,1));
  134. mdl2 = fitlm(pcscore, Y_res(:,n));
  135. % mdl2 = fitlm(X, Y_res(:,n));
  136. r(n) = mdl2.Rsquared.Ordinary;
  137. ypred(:,n) = predict(mdl2,pcscore);
  138. end
  139. Y_net = var(ypred(:))/Y_totvar;
  140. % Y_net = mean(r);
  141. popResp_var = cat(1, popResp_var,[Y_stimexp, Y_pupildynexp_RRR, Y_net,areaID(k1,k2), k]);
  142. end
  143. end
  144. end
  145. end
  146. end
  147. figure, boxplot(popResp_var(:,1:3), 'whisker', 10)
  148. box off
  149. set(gca, 'Xticklabels', {'Stimulus','Pupil dynamics','Network'})
  150. ylabel('Variance explained')
  151. title('Partition variance of population neuron response ')
  152. %% 1D pupil dynamics
  153. binWidth = 100;
  154. smoothSD = 2;
  155. ind = 1;
  156. for k1 = 1:length(poolpupildata)
  157. if ~isempty(poolpupildata(k1).pupildata)
  158. pupildata = poolpupildata(k1).pupildata;
  159. if isfield(pupildata, 'pupilsync')
  160. pupilsync = pupildata.pupilsync;
  161. sync2p = table2array(poolpupildata(k1).sync2p);
  162. l0 = find(pupilsync(:,3)==1,1);
  163. l1 = find(pupilsync(:,3)==1,1,'last');
  164. pupildyn = [pupildata.eyearea(l0:l1)',pupildata.eyecenter(l0:l1,:),pupildata.videoscore];
  165. pupildyn(pupildyn(:,1)==0,1:3) = nan;
  166. pupilPC(k1,1:2) = [pupildata.video_PCdim, pupildata.video_PCvar];
  167. pupildyn_t = pupilsync(l0:l1,1:2);
  168. pupildyn_t = bsxfun(@minus, pupildyn_t, pupildyn_t(1,:))+1;
  169. pupildyn_match2p = [];
  170. for j = 1:size(pupildyn,2)
  171. tmp = interp1(pupildyn_t(:,1)/pupildyn_t(end,1), pupildyn(:,j), sync2p(:,1)/sync2p(end,1));
  172. pupildyn_match2p = cat(2, pupildyn_match2p, tmp);
  173. end
  174. imgPara = pooldata(k1,1).imgPara;
  175. % pupil dynamics bined per direction (2 sec window)
  176. pupildyn_bin = [];
  177. for i = 1:imgPara.stimrep
  178. for j = 1:imgPara.stim_type
  179. tmp = pupildyn_match2p(sync2p(:,3)==i & sync2p(:,5)==j,:);
  180. tmp1 = imresize(tmp, [8 size(tmp,2)]);
  181. pupildyn_bin = cat(1, pupildyn_bin, tmp1);
  182. end
  183. end
  184. X_pupildyn = pupildyn_bin;
  185. X_stim = repmat(stimflag, imgPara.stimrep, 1);
  186. for k2 = 1:4
  187. if ~isempty(pooldata(k1,k2).spiketrain) && length(pooldata(k1,k2).goodcell) > 5
  188. goodcell = pooldata(k1,k2).goodcell;
  189. spiketrain = pooldata(k1,k2).spiketrain(goodcell);
  190. num(k1,k2) = length(goodcell);
  191. spikecountAve = []; h = []; spikecountraw1 = [];
  192. spikecountraw2 = []; snr = [];
  193. for n = 1:length(goodcell)
  194. tmphist = [];
  195. stvec = [];
  196. for i = 1:imgPara.stimrep
  197. st1 = [];
  198. for j = 1:imgPara.stim_type
  199. st = spiketrain(n).st{i,j}*imgPara.dt;
  200. st(st<0) = [];
  201. st(st>imgPara.stim_time) = [];
  202. st1 = [st1, st+imgPara.stim_time*(j-1)];
  203. tmphist1 = histcounts(st, Twindow);
  204. tmphist = cat(1, tmphist, tmphist1');
  205. end
  206. stvec = vectCat(stvec, st1');
  207. end
  208. [rate , rateT] = myPSTH(stvec*1000, [0, imgPara.stim_time*imgPara.stim_type]*1000, binWidth, smoothSD);
  209. spikecountraw1(n,:) = tmphist;
  210. spikecountAve(n,:) = rate;
  211. end
  212. % total variance of population response
  213. Y = spikecountraw1';
  214. Y = bsxfun(@minus, Y, mean(Y,1));
  215. Y_totvar = var(Y(:));
  216. % variance explained by stimulus induced response
  217. Ym = mean(reshape(Y, 72,imgPara.stimrep,size(Y,2)), 2);
  218. Ym_var = var(Ym(:));
  219. Y_stimexp = Ym_var/Y_totvar;
  220. % residual population response after subtracting stimulus
  221. % induced portion (estimated by trial averaged response)
  222. Y = bsxfun(@minus, reshape(Y, 72,imgPara.stimrep,size(Y,2)), Ym);
  223. Y = reshape(Y,[],size(Y,3));
  224. Y_resvar = var(Y(:));
  225. % ordinary regression variance explained by pupil dynamics
  226. X = X_pupildyn;
  227. X(isnan(X)) = 0;
  228. [Br, Bols, ~, ~] = RRR_bySVD(X, Y, 1);
  229. Yhat2 = X * Br;
  230. Y_pupildynexp_RRR = var(Yhat2(:))/Y_totvar;
  231. popResp_var(ind, 6) = Y_pupildynexp_RRR;
  232. ind = ind+1;
  233. end
  234. end
  235. end
  236. end
  237. end
  238. figure, boxplot(popResp_var(:,[1,2,6,3]), 'whisker', 10)
  239. box off
  240. set(gca, 'Xticklabels', {'Stimulus','Pupil dynamics','1D Pupil dynamics','Network'})
  241. ylabel('Variance explained')
  242. title('Partition variance of population neuron response ')

FR_pupilAna.m at commit 4da24c0, under GPL-3.0 · at the source

Overview

Authors: Yiyi Yu1, Jeffery N Stirman1, Christopher R Dorsett1, Spencer LaVere Smith1,2
  1. Department of Electrical and Computer Engineering, University of California, Santa Barbara, Santa Barbara, United States
  2. Dynamical Neurosciences, University of California, Santa Barbara, Santa Barbara, United States
Institutions: University of California, Santa Barbara (United States)
Journal: eLife, volume 13, article RP97848
Dates: published online 24 March 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.7554/elife.97848 · PMID 41874539 · PMCID PMC13012721 · OpenAlex W4399364508
Open access: gold, a free copy (OpenAlex)
Status: code verified (how the code is found and verified)
Categories: mouse (organism)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Connectivity, fMRI & imaging, Single-unit activity, calcium imaging, Physiology & signal measures
Keywords: Mouse
MeSH: Nerve Net*, Neurons*, Primary Visual Cortex*, Visual Cortex*, Visual Pathways*, Animals, Calcium, Mice (* major topic)
Topic: Neural dynamics and brain function (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: NIH HHS (R01NS091335, T32NS007431, R01EY024294); Simons Foundation (SCGB325407); NSF (1450824, 1707287); NEI NIH HHS (R01 EY035378); NINDS NIH HHS (R01 NS121919)
Citations: cited by 3 papers (Europe PMC); 74 references in the paper

Abstract

Among brain areas, axonal projections carry channels of information that can be mixed to varying degrees. Here, we assess the rules for the network consisting of the primary visual cortex and higher visual areas (V1-HVA) in mice. We use large field-of-view two-photon calcium imaging to measure correlated variability (i.e. noise correlations, NCs) among thousands of neurons, forming over a million unique pairs, distributed across multiple cortical areas simultaneously. The amplitude of NCs is proportional to functional connectivity in the network, and we find that they are robust, reproducible statistical measures and are remarkably similar across stimuli, thus providing effective constraints to network models. We used these NCs to measure the statistics of functional connectivity among tuning classes of neurons in V1 and HVAs. Using a data-driven clustering approach, we identify approximately 60 distinct tuning classes found in V1 and HVAs. We find that NCs are higher between neurons from the same tuning class, both within and across cortical areas. Thus, in the V1-HVA network, mixing of channels is avoided. Instead, distinct channels of visual information are broadcast within and across cortical areas, at both the micron and millimeter length scales. This principle for the functional organization and correlation structure at the individual neuron level across multiple cortical areas can inform and constrain computational theories of neocortical networks.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repository

Its files are read in the Code ↔ Paper reader above, with 4 matches between paragraphs and lines of code.

yuyiyi/Broadcast_channel

License: GPL-3.0
State: the link answers, verified on 30 September 2026
Evidence: files inventoried
Commit: 4da24c0febfb9591ac9cd683920095e79cb429bb, 27 February 2026
Languages: MATLAB (5)
Size: 26 files, 5 scripts
Software Heritage: not archived
Found in: “Data availability”
Holds: README, license file
Not found: CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 30 September 2026: the link answers
  • 30 September 2026: the link answers
7 files

The paper's code and data availability statement is in the Data section.

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Data

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Data availability

Data and code generated in the current study are available on github https://github.com/yuyiyi/Broadcast_channel (copy archived at Yu, 2026).

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 4 authors, 1 keyword, 8 MeSH terms, 5 funders, 72 references.

Cite

This paper

Yu, Y., Stirman, J. N., Dorsett, C. R., & Smith, S. L. (2026). Visual information is broadcast among cortical areas in discrete channels. eLife, 13, RP97848. https://doi.org/10.7554/elife.97848

BibTeX

@article{yu2026visual,
author = {Yu, Yiyi and Stirman, Jeffery N and Dorsett, Christopher R and Smith, Spencer LaVere},
title = {{Visual information is broadcast among cortical areas in discrete channels}},
journal = {eLife},
year = {2026},
month = mar,
volume = {13},
pages = {RP97848},
publisher = {eLife Sciences Publications, Ltd},
issn = {2050-084X},
doi = {10.7554/elife.97848},
url = {https://doi.org/10.7554/elife.97848},
pmid = {41874539},
pmcid = {PMC13012721}
}

RIS

TY - JOUR
AU - Yu, Yiyi
AU - Stirman, Jeffery N
AU - Dorsett, Christopher R
AU - Smith, Spencer LaVere
TI - Visual information is broadcast among cortical areas in discrete channels
T2 - eLife
J2 - eLife
PY - 2026
DA - 2026/03/24
VL - 13
SP - RP97848
SN - 2050-084X
PB - eLife Sciences Publications, Ltd
DO - 10.7554/elife.97848
UR - https://doi.org/10.7554/elife.97848
LA - en
ER -

CSL-JSON

{
"id": "10.7554/elife.97848",
"type": "article-journal",
"title": "Visual information is broadcast among cortical areas in discrete channels",
"container-title": "eLife",
"author": [
{
"family": "Yu",
"given": "Yiyi"
},
{
"family": "Stirman",
"given": "Jeffery N"
},
{
"family": "Dorsett",
"given": "Christopher R"
},
{
"family": "Smith",
"given": "Spencer LaVere"
}
],
"container-title-short": "eLife",
"volume": "13",
"page": "RP97848",
"DOI": "10.7554/elife.97848",
"PMID": "41874539",
"PMCID": "PMC13012721",
"ISSN": "2050-084X",
"publisher": "eLife Sciences Publications, Ltd",
"URL": "https://doi.org/10.7554/elife.97848",
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
24
]
]
}
}

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