Excitatory cholecystokinin neurons in the CA3 area regulate the navigation learning and neuroplasticity.
Overview
- Department of Neuroscience, City University of Hong Kong Hong Kong China
- Department of Ophthalmology, Stanford University School of Medicine Palo Alto United States
Abstract
Hippocampus, a key hub of neural circuits for spatial learning and memory, has attracted tremendous studies. Neuronal information processing in the hippocampus can be regulated by many types of neuropeptides. Cholecystokinin (Cck), the most abundant neuropeptide in the central nervous system that is involved in modulating neuronal functions, such as cognition, memory, and neuroplasticity, is widely expressed in the hippocampus. However, whether local excitatory Cck neurons modulate hippocampal function is still unclear. In this study, we showed that CA1 pyramidal neurons receive projections from excitatory Cck neurons in area CA3 (CA3Cck neurons) in adult mice. Subsequently, activation of the CA1-projecting CA3Cck neurons triggers the release of Cck. Then, we found that the activity of CA3Cck-CA1 neurons supports the hippocampal-dependent tasks. Furthermore, inhibition of CA3Cck-CA1 projections or knockdown of CA3Cck gene expression markedly impaired the behavioral tasks and neuroplasticity. Taken together, these results may add to a better understanding of how neuromodulators regulate the neural functions in the central nervous system.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- doi:10.5061/
dryad.r4xgxd2gq — at Dryad; found in “Data availability”
Data availability
All behavioral, electrophysiological, immunohistochemical, and neurochemical data have been deposited at https://
The following dataset was generated:
YueS Dryad Digital Repository2022High-densi
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 3 authors, 4 keywords, 11 MeSH terms, 1 funder, 40 references, 2 RRIDs.
Cite
This paper
Huang, F., Baset, A., & Bello, S. T. (2026). Excitatory cholecystokinin neurons in the CA3 area regulate the navigation learning and neuroplasticity. eLife, 14, RP109001. https://
BibTeX
@article{huang2026excita
author = {Huang, Fengwen and Baset, Abdul and Bello, Stephen Temitayo},
title = {{Excitatory cholecystokinin neurons in the CA3 area regulate the navigation learning and neuroplasticity}},
journal = {eLife},
year = {2026},
month = jul,
volume = {14},
pages = {RP109001},
publisher = {eLife Sciences Publications, Ltd},
issn = {2050-084X},
doi = {10.7554/
url = {https://
pmid = {42517343},
pmcid = {PMC13412322}
}
RIS
TY - JOUR
AU - Huang, Fengwen
AU - Baset, Abdul
AU - Bello, Stephen Temitayo
TI - Excitatory cholecystokinin neurons in the CA3 area regulate the navigation learning and neuroplasticity
T2 - eLife
J2 - eLife
PY - 2026
DA - 2026/
VL - 14
SP - RP109001
SN - 2050-084X
PB - eLife Sciences Publications, Ltd
DO - 10.7554/
UR - https://
LA - en
ER -
CSL-JSON
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"URL": "https://
"language": "en",
"issued": {
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