Differential locus coeruleus-hippocampus interactions during offline states.

Overview

1. Department of Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, Tübingen, Germany

Abstract

Patterns of locus coeruleus (LC) activity and norepinephrine (NE) release during non-rapid-eye-movement sleep suggest a critical role for the LC–NE system in offline modulation of forebrain circuits. NE transmission promotes synaptic plasticity and is required for memory consolidation, but the field has only begun to uncover how LC activity contributes to coordinated forebrain network dynamics. Hippocampal ripples, a hallmark of memory replay, are temporally coupled with thalamocortical oscillations; however, the circuit mechanisms underlying system-level consolidation across larger brain networks remain incompletely understood. Here, using multi-site electrophysiology, we examined LC firing in relation to hippocampal ripples in freely behaving rats. LC activity and ripple occurrence were state-dependent and inversely related: heightened arousal was associated with increased LC firing and reduced ripple rates. At finer timescales, LC spiking decreased ∼1–2 s before ripple onset, with the strongest modulation during awake ripples but minimal change during ripple–spindle coupling. These findings reveal state-dependent dynamics of LC–hippocampal interactions, positioning the LC as a key component of a cortical–subcortical network supporting system-level memory consolidation.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

• doi:10.5061/dryad.c59zw3rrb, at Dryad; found in “Data availability”

Data availability

Source data and raw data files are publicly available through the Dryad Digital Repository under the title "Differential locus coeruleus–hippocampus interactions during offline states" by Mingyu Yang and Oxana Eschenko (2026) and the following accession code: DOI: 10.5061/dryad.c59zw3rrb (https://doi.org/10.5061/dryad.c59zw3rrb). Any further requests for information or materials should be addressed to the corresponding author.

The following dataset was generated:

Yang M, Eschenko O. 2026. Differential locus coeruleus–hippocampus interactions during offline states. Dryad Digital Repository.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 2 authors, 1 keyword, 8 MeSH terms, 59 references, 2 RRIDs.

Cite

This paper

Yang, M., & Eschenko, O. (2026). Differential locus coeruleus-hippocampus interactions during offline states. eLife, 14, RP109159. https://doi.org/10.7554/elife.109159

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