Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys.
The 1 match
- [1] § Methods › Relate neural activity to DDM components ↔ Code/Figure4_splitFR.m, lines 1–115 · score 0.54 · epoch combination, DDM parameter, firing rates, split, fitted, neural
Paper
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The authors' code
MATLAB · 333 lines · 12 KB · no license · 1 match
Figure4_splitFR.m, no license · at the source
Overview
Abstract
The subthalamic nucleus (STN) is a part of the indirect and hyperdirect pathways in the basal ganglia (BG) and has been implicated in movement control, impulsivity, and decision-making. We recently demonstrated that, for perceptual decisions, the STN includes at least three subpopulations of neurons with different decision-related activity patterns (Branam et al., 2024). Here, we show that, for decisions that require both perceptual and reward-based processing, many STN neurons are sensitive to both sensory evidence and reward expectations. Within a drift-diffusion framework, three STN subpopulations show different relationships to model components reflecting the formation of the decision variable, dynamics of the decision bound, and non-decision-related processes. Many STN neurons also represent quantities related to decision evaluation, including choice accuracy and reward expectation. These results help to further delineate the multiple roles that STN plays in forming and evaluating complex decisions that combine multiple sources of information.
Reproduced under the paper's license (CC BY), from the paper cited above.
Repository
Its files are read in the Code ↔ Paper reader above, with 1 match between paragraphs and lines of code.
OSF jdk9v
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
- 27 September 2026: the link answers (HTTP 200)
37 files, to read at the source
This repository has no license: its authors keep all rights. Read it at the source.
- Code/
EvalSignal_runningPartia — MATLAB, 95 lines, not shown herelCorrSac.m - Code/
Figure1_plotBehavior.m — MATLAB, 134 lines, not shown here - Code/
Figure2_plot_3exampleneu — MATLAB, 275 lines, not shown hererons.m - Code/
Figure3S1_plot_runningRe — MATLAB, 214 lines, not shown heregHeatmapFraction.m - Code/
Figure3S2_Compare_FEF_ca — MATLAB, 132 lines, not shown hereudate_STN.m - Code/
Figure3_epoch_regression — MATLAB, 146 lines, not shown here.m - Code/
Figure4_splitFR.m — MATLAB, 333 lines, 1 match, not shown here - Code/
Figure5_clusterResults.m — MATLAB, 406 lines, not shown here - Code/
Figure5_suppl_histogramS — MATLAB, 60 lines, not shown hereplitFR_byCluster.m - Code/
Figure6_rewcont_DDM_Neur — MATLAB, 123 lines, not shown hereal.m - Code/
Figure7_evalSignals_fdr. — MATLAB, 398 lines, not shown herem - Code/
Figure8_STN_locations.m — MATLAB, 147 lines, not shown here - Code/
STN_cluster_Linkage.m — MATLAB, 220 lines, not shown here - Code/
STN_cluster_Linkage_byMo — MATLAB, 260 lines, not shown herenkey.m - Code/
STN_cluster_Linkage_subT — MATLAB, 212 lines, not shown hererial.m - Code/
STN_cluster_kmeans.m — MATLAB, 190 lines, not shown here - Code/
STN_cluster_kmeans_byMon — MATLAB, 220 lines, not shown herekey.m - Code/
STN_cluster_kmeans_subTr — MATLAB, 236 lines, not shown hereial.m - Code/
chi_square_testLD.m — MATLAB, 14 lines, not shown here - Code/
dendrogramMod.m — MATLAB, 528 lines, not shown here - Code/
exclude_dissimilar_neuro — MATLAB, 12 lines, not shown herens.m - Code/
extract_epoch_FR.m — MATLAB, 43 lines, not shown here - Code/
extract_epoch_FR_finerWi — MATLAB, 57 lines, not shown herendows.m - Code/
genFigRectangleAxes.m — MATLAB, 33 lines, not shown here - Code/
generate_vector.m — MATLAB, 95 lines, not shown here - Code/
identify_mod_neurons.m — MATLAB, 78 lines, not shown here - Code/
perform_clustering.m — MATLAB, 20 lines, not shown here - Code/
plot_combinedSDF_selectU — MATLAB, 171 lines, not shown herenits.m - Code/
plot_combinedSDF_selectU — MATLAB, 170 lines, not shown herenits_contrastAR.m - Code/
plot_epoch_regression_re — MATLAB, 51 lines, not shown heresults.m - Code/
plot_stacked_hist.m — MATLAB, 40 lines, not shown here - Code/
randIndex.m — MATLAB, 27 lines, not shown here - Code/
rename_xtick0.m — MATLAB, 8 lines, not shown here - Code/
retrieve_regression.m — MATLAB, 70 lines, not shown here - Code/
runningRegressionRT_Coh_ — MATLAB, 191 lines, not shown hereTgtDotsSac20260217.m - Code/
standardize_cluster_orde — MATLAB, 61 lines, not shown herer.m - Code/
z_scoreFR.m — MATLAB, 28 lines, not shown here
The paper's code and data availability statement is in the Data section.
Tracing map
Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.
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- 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
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- 1 match between paragraphs of the paper and lines of the code (method lexical-v1);
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Data
No dataset and no data link were found in the paper.
Data availability
All electrophysiological data and the code for the analyses presented in the paper are deposited at OSF (https://
The following previously published dataset was used:
Ding L. 2026. STN asymmetric reward decision making. Open Science Framework. jdk9v
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 3 authors, 1 keyword, 7 MeSH terms, 1 funder, 50 references, 2 RRIDs.
Cite
This paper
Branam, K., Gold, J. I., & Ding, L. (2026). Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys. eLife, 15, RP109622. https://
BibTeX
@article{branam2026disti
author = {Branam, Kathryn and Gold, Joshua I and Ding, Long},
title = {{Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys}},
journal = {eLife},
year = {2026},
month = jul,
volume = {15},
pages = {RP109622},
publisher = {eLife Sciences Publications, Ltd},
issn = {2050-084X},
doi = {10.7554/
url = {https://
pmid = {42383848},
pmcid = {PMC13322701}
}
RIS
TY - JOUR
AU - Branam, Kathryn
AU - Gold, Joshua I
AU - Ding, Long
TI - Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys
T2 - eLife
J2 - eLife
PY - 2026
DA - 2026/
VL - 15
SP - RP109622
SN - 2050-084X
PB - eLife Sciences Publications, Ltd
DO - 10.7554/
UR - https://
LA - en
ER -
CSL-JSON
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