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Structural and Quantitative MRI Signal Features in Pediatric Focal Cortical Dysplasia: Clinical Relevance.

Overview

Authors: Zuzana HOLUBOVÁ1,2, David KALA3,2, Václav ČAPEK1, Nora PROFANTOVÁ1,2, Barbora SPLÍTKOVÁ4, Jan ŠANDA1,2, Yeva PRYSIAZHNIUK3,2, Kateřina JIRÁNKOVÁ5, Martin KUDR4,2, Pavel KRŠEK4,2, Martin KYNČL1,2, Jakub OTÁHAL3,2
  1. Department of Medical Imaging, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague 5, Czech Republic
  2. Epilepsy Research Center Prague, EpiReC, Prague, Czech Republic
  3. Department of Pathophysiology, Second Faculty of Medicine, Charles University, Prague 5, Czech Republic
  4. Department of Paediatric Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague 5, Czech Republic
  5. Department of Radiology and Nuclear Medicine, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague 10, Czech Republic
Institutions: Charles University (Czechia); University Hospital in Motol (Czechia); University Hospital Kralovske Vinohrady (Czechia)
Journal: Physiological research, volume 75, issue 3, pages 597-612
Dates: received 11 March 2026; accepted 12 March 2026; published online 1 June 2026; in print July 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI · PMID 42484082 · PMCID PMC13557539 · OpenAlex W7170066455
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: structural MRI / diffusion (modality), human (organism), epilepsy (population), clinical / translational (subfield)
Methods: Statistics, fMRI & imaging
Keywords: Focal cortical dysplasia, Signal intensity, Structural MRI, Pediatric, Quantitative T1
MeSH: Focal Cortical Dysplasia*, Magnetic Resonance Imaging*, Adolescent, Child, Child, Preschool, Clinical Relevance, Female, Humans, Male (* major topic)
Topic: Epilepsy research and treatment (Psychiatry and Mental health, Medicine), according to OpenAlex
Funding: Czech Health Research Council (NW25-08-00371, NU21-08-00228, NW25-04-00427); European Union – Next Generation EU, and supported by ERDF-Project Brain dynamics (CZ.02.01.01/00/22_008/0004643)
Citations: not cited yet (Europe PMC); 51 references in the paper

Abstract

The aim of this study was to quantitatively characterize MRI signal-intensity (SI) abnormalities in focal cortical dysplasia (FCD) and to compare expert visual lesion delineation with objective SI metrics across conventional structural MRI sequences and quantitative T1 mapping (qT1). Thirteen pediatric patients with histologically confirmed FCD type I or II underwent presurgical MRI including 3D T1-weighted, T2-weighted, FLAIR, and qT1 sequences. Two expert-defined lesion masks were generated: a conservative feature-focused mask (L1) and a broader contextual mask reflecting overall radiological judgement (L2). Signal-intensity values were extracted from lesions, perilesional zones, and contralateral homologous regions, and spatial correspondence with the resection cavity was evaluated using the Dice score. L2 delineations were substantially larger and showed markedly higher overlap with resected tissue than L1, suggesting that expert contextual assessment captures clinically relevant but quantitatively subtle abnormalities. In contrast, L1 showed stronger and more consistent SI abnormalities, particularly on T2-weighted and FLAIR images, indicating that expert visual judgement and quantitative SI metrics do not fully converge. Perilesional tissue closely resembled healthy brain, with only minimal SI gradients beyond the lesion border. Quantitative T1 mapping provided limited additional value over conventional T1-weighted imaging for the detection of white-matter abnormalities. These findings indicate that expert assessment and quantitative MRI capture complementary but non-identical aspects of FCD pathology, and suggest that future automated detection models should combine quantitative features with multiple layers of radiological expertise.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 5 keywords, 9 MeSH terms, 2 funders, 51 references.

Cite

This paper

HOLUBOVÁ, Z., KALA, D., ČAPEK, V., PROFANTOVÁ, N., SPLÍTKOVÁ, B., ŠANDA, J., PRYSIAZHNIUK, Y., JIRÁNKOVÁ, K., KUDR, M., KRŠEK, P., KYNČL, M., & OTÁHAL, J. (2026). Structural and Quantitative MRI Signal Features in Pediatric Focal Cortical Dysplasia: Clinical Relevance. Physiological research, 75(3), 597-612.

BibTeX

@article{holubova2026structural,
author = {HOLUBOVÁ, Zuzana and KALA, David and ČAPEK, Václav and PROFANTOVÁ, Nora and SPLÍTKOVÁ, Barbora and ŠANDA, Jan and PRYSIAZHNIUK, Yeva and JIRÁNKOVÁ, Kateřina and KUDR, Martin and KRŠEK, Pavel and KYNČL, Martin and OTÁHAL, Jakub},
title = {{Structural and Quantitative MRI Signal Features in Pediatric Focal Cortical Dysplasia: Clinical Relevance}},
journal = {Physiological research},
year = {2026},
month = jul,
volume = {75},
number = {3},
pages = {597--612},
publisher = {Institute of Physiology, Czech Academy of Sciences},
issn = {0862-8408},
pmid = {42484082},
pmcid = {PMC13557539}
}

RIS

TY - JOUR
AU - HOLUBOVÁ, Zuzana
AU - KALA, David
AU - ČAPEK, Václav
AU - PROFANTOVÁ, Nora
AU - SPLÍTKOVÁ, Barbora
AU - ŠANDA, Jan
AU - PRYSIAZHNIUK, Yeva
AU - JIRÁNKOVÁ, Kateřina
AU - KUDR, Martin
AU - KRŠEK, Pavel
AU - KYNČL, Martin
AU - OTÁHAL, Jakub
TI - Structural and Quantitative MRI Signal Features in Pediatric Focal Cortical Dysplasia: Clinical Relevance
T2 - Physiological research
J2 - Physiol Res
PY - 2026
DA - 2026/07/01
VL - 75
IS - 3
SP - 597
EP - 612
SN - 0862-8408
PB - Institute of Physiology, Czech Academy of Sciences
LA - en
ER -

CSL-JSON

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