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TrkC-dependent regulation of dendritic branching shapes dendritic bundle architecture in the rat granular retrosplenial cortex

Overview

Authors: Toshio Miyashita1
  1. Department of Anatomy, Teikyo University School of Medicine, Tokyo, Japan
Journal: Frontiers in neural circuits, volume 20, article 1925955
Dates: received 2 July 2026; accepted 7 September 2026; published online 24 September 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI · PMCID PMC13646102
Status: data only (how the code is found and verified)
Categories: rat (organism)
Methods: Spectral & time-frequency, Statistics, Smoothing, state filtering, decompositions, Machine learning, Preprocessing, Evoked potentials, Connectivity
Keywords: cortical module, dendrite, layer 1, minicolumn, NT-3
Citations: not cited yet (Europe PMC); 33 references in the paper

Abstract

Cortical modules are thought to provide anatomical frameworks for local microcircuits. However, the mechanisms regulating the morphological organization of these modules during development remain poorly understood. In the rat granular retrosplenial cortex, layer 1 contains prominent dendritic bundle-centered modules formed by the apical dendrites of layer 2 neurons and aligned with specific afferent inputs. I investigated the molecular mechanisms regulating the architecture of these dendritic bundles, focusing on TrkC, a high-affinity receptor for neurotrophin-3. Reanalysis of developmental gene expression data showed that neurotrophin-3 was transiently enriched in layer 2 before dendritic bundle formation, whereas TrkC expression was maintained at above-average levels and became modestly elevated after bundle formation. Pathway analysis further suggested developmental changes in neurotrophin pathways. To examine whether perturbation of TrkC-related signaling affects dendritic bundle architecture, I overexpressed a truncated TrkC construct lacking the intracellular tyrosine kinase domain in layer 2 neurons via in utero electroporation. Overexpression of this construct expanded dendritic bundle territories in upper layer 1. Sparse single-cell labeling revealed that this bundle-level phenotype was accompanied by increased branching of the apical dendrites of individual layer 2 neurons. These findings suggest that TrkC-related signaling may regulate the morphology of dendritic bundles by restricting excessive branching of apical dendrites during development. Thus, regulation of dendritic branching may contribute to the refinement of the distinctive dendritic bundle architecture of the granular retrosplenial cortex.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data

Datasets cited

Data availability statement

The GeneChip data analyzed in this study are publicly available in the NCBI Gene Expression Omnibus (GEO) under accession number GSE346953: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346953.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 1, 9 October 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 1 author, 5 keywords, 33 references.

Cite

This paper

Miyashita, T. (2026). TrkC-dependent regulation of dendritic branching shapes dendritic bundle architecture in the rat granular retrosplenial cortex. Frontiers in neural circuits, 20, 1925955.

BibTeX

@article{miyashita2026trkc,
author = {Miyashita, Toshio},
title = {{TrkC-dependent regulation of dendritic branching shapes dendritic bundle architecture in the rat granular retrosplenial cortex}},
journal = {Frontiers in neural circuits},
year = {2026},
month = oct,
volume = {20},
pages = {1925955},
publisher = {Frontiers Media SA},
issn = {1662-5110},
pmcid = {PMC13646102}
}

RIS

TY - JOUR
AU - Miyashita, Toshio
TI - TrkC-dependent regulation of dendritic branching shapes dendritic bundle architecture in the rat granular retrosplenial cortex
T2 - Frontiers in neural circuits
J2 - Front Neural Circuits
PY - 2026
DA - 2026/10/09
VL - 20
SP - 1925955
SN - 1662-5110
PB - Frontiers Media SA
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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