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Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice

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The authors' code

Python · 334 lines · 14 KB · Apache-2.0

  1. #Copyright 2015-2017 MathWorks, Inc.
  2. # This template is used to generate an __init__.py file for a particular deployable package.
  3. """ Package for executing deployed MATLAB functions """
  4. from __future__ import print_function
  5. import atexit
  6. import glob
  7. import importlib
  8. import os
  9. import os.path
  10. import pdb
  11. import platform
  12. import sys
  13. import weakref
  14. class _PathInitializer(object):
  15. PLATFORM_DICT = {'Windows': ['PATH','dll',''], 'Linux': ['LD_LIBRARY_PATH','so','libmw'], 'Darwin': ['DYLD_LIBRARY_PATH','dylib','libmw']}
  16. SUPPORTED_PYTHON_VERSIONS = ['2_7', '3_4', '3_5', '3_6']
  17. RUNTIME_VERSION_W_DOTS = '9.3'
  18. RUNTIME_VERSION_W_UNDERSCORES = '9_3'
  19. PACKAGE_NAME = 'STNeuroNetPkg'
  20. def set_interpreter_version(self):
  21. """Make sure the interpreter version is supported."""
  22. ver = sys.version_info
  23. version = '{0}_{1}'.format(ver[0], ver[1])
  24. if version in _PathInitializer.SUPPORTED_PYTHON_VERSIONS:
  25. self.interpreter_version = version
  26. else:
  27. version_with_dot = version.replace("_", ".")
  28. raise EnvironmentError("Python {0} is not supported.".format(version_with_dot))
  29. def __init__(self):
  30. """Initialize the variables."""
  31. self.arch = ''
  32. self.is_linux = False
  33. self.is_mac = False
  34. self.is_windows = False
  35. self.mr_handle = None
  36. self.ml_handle = None
  37. self.system = ''
  38. self.cppext_handle = None
  39. # path to the folder that stores Python extensions and shared libraries
  40. self.bin_dir = ''
  41. # path to the folder that stores pure Python matlab_pysdk.runtime code (_runtime_dir)
  42. self.runtime_dir = ''
  43. # path to the folder that stores the pure Python matlab mlarray code used for type conversion
  44. self.ml_dir = ''
  45. self.set_interpreter_version()
  46. self.get_platform_info()
  47. this_folder = os.path.dirname(os.path.realpath(__file__))
  48. self.path_file_name = os.path.join(this_folder, 'paths.{0}.txt'.format(self.arch))
  49. self.instances_of_this_package = set([])
  50. def read_path_file(self):
  51. """Look for a file that lists items to add to path. If present, read it and add the paths."""
  52. filtered_lines = []
  53. if os.path.isfile(self.path_file_name):
  54. pth_file = open(self.path_file_name, 'r')
  55. lines = pth_file.readlines()
  56. for line in lines:
  57. stripped_line = line.strip()
  58. if stripped_line and stripped_line[0] != '#':
  59. filtered_lines.append(stripped_line)
  60. length = len(filtered_lines)
  61. if length == 3:
  62. (bin_dir, runtime_dir, ml_dir) = filtered_lines
  63. if (not os.path.isdir(bin_dir)) or (not os.path.isdir(runtime_dir)) or (not os.path.isdir(ml_dir)):
  64. return False
  65. else:
  66. (self.bin_dir, self.runtime_dir, self.ml_dir) = (bin_dir, runtime_dir, ml_dir)
  67. return True
  68. else:
  69. return False
  70. def write_path_file(self):
  71. """Write a file that lists items to add to path. If present, it will be overwritten."""
  72. existing_contents = ''
  73. if os.path.isfile(self.path_file_name):
  74. path_file = open(self.path_file_name, 'r')
  75. existing_contents = path_file.readlines()
  76. path_file.close()
  77. path_file = open(self.path_file_name, 'w')
  78. if self.system == 'Windows':
  79. print('# bin dir: added to both OS path and system path', file=path_file)
  80. else:
  81. print('# bin dir: added to system path', file=path_file)
  82. print(self.bin_dir, file=path_file)
  83. print('', file=path_file)
  84. print('# runtime dir: added to system path', file=path_file)
  85. print(self.runtime_dir, file=path_file)
  86. print('', file=path_file)
  87. print('# matlab (mlarray) dir: added to system path', file=path_file)
  88. print(self.ml_dir, file=path_file)
  89. print('', file=path_file)
  90. if existing_contents:
  91. print(existing_contents, file=path_file)
  92. path_file.close()
  93. def get_platform_info(self):
  94. """Ask Python for the platform and architecture."""
  95. # This will return 'Windows', 'Linux', or 'Darwin' (for Mac).
  96. self.system = platform.system()
  97. if not self.system in _PathInitializer.PLATFORM_DICT:
  98. raise RuntimeError('{0} is not a supported platform.'.format(self.system))
  99. else:
  100. # path_var is the OS-dependent name of the path variable ('PATH', 'LD_LIBRARY_PATH', "DYLD_LIBRARY_PATH')
  101. (self.path_var, self.ext, self.lib_prefix) = _PathInitializer.PLATFORM_DICT[self.system]
  102. if self.system == 'Windows':
  103. self.is_windows = True
  104. bit_str = platform.architecture()[0]
  105. if bit_str == '64bit':
  106. self.arch = 'win64'
  107. elif bit_str == '32bit':
  108. self.arch = 'win32'
  109. else:
  110. raise RuntimeError('{0} is not supported.'.format(bit_str))
  111. elif self.system == 'Linux':
  112. self.is_linux = True
  113. self.arch = 'glnxa64'
  114. elif self.system == 'Darwin':
  115. self.is_mac = True
  116. self.arch = 'maci64'
  117. else:
  118. raise RuntimeError('Operating system {0} is not supported.'.format(self.system))
  119. def get_paths_from_os(self):
  120. """
  121. Look through the system path for a file whose name contains a runtime version
  122. corresponding to the one with which this package was produced.
  123. """
  124. # Concatenates the pieces into a string. The double parentheses are necessary.
  125. if self.system == 'Windows':
  126. file_to_find = ''.join((self.lib_prefix, 'mclmcrrt',
  127. _PathInitializer.RUNTIME_VERSION_W_UNDERSCORES, '.', self.ext))
  128. elif self.system == 'Linux':
  129. file_to_find = ''.join((self.lib_prefix, 'mclmcrrt', '.', self.ext, '.',
  130. _PathInitializer.RUNTIME_VERSION_W_DOTS))
  131. elif self.system == 'Darwin':
  132. file_to_find = ''.join((self.lib_prefix, 'mclmcrrt', '.',
  133. _PathInitializer.RUNTIME_VERSION_W_DOTS,
  134. '.', self.ext))
  135. else:
  136. raise RuntimeError('Operating system {0} is not supported.'.format(self.system))
  137. path_elements = []
  138. if self.path_var in os.environ:
  139. path_elements = os.environ[self.path_var].split(os.pathsep)
  140. if not path_elements:
  141. friendly_os_name = self.system
  142. if friendly_os_name == 'Darwin':
  143. friendly_os_name = 'Mac'
  144. raise RuntimeError('On {0}, you must set the environment variable "{1}" to a non-empty string. {2}'.format(
  145. friendly_os_name, self.path_var, 'For more details, see the package documentation.'))
  146. path_found = ''
  147. for elem in path_elements:
  148. filename = os.path.join(elem, file_to_find)
  149. if (os.path.isfile(filename)):
  150. path_found = elem
  151. break
  152. if not path_found:
  153. raise RuntimeError('Could not find an appropriate directory for MATLAB or the MATLAB runtime in {0}. Details: {1}'.format(
  154. self.path_var, file_to_find))
  155. # The last nonblank part of the path should be the arch (e.g., "win64").
  156. path_components = path_found.split(os.sep)
  157. if path_components[-1]:
  158. last_path_component = path_components[-1]
  159. else:
  160. # The directory name ended with a slash, so the last item in the list was an empty string. Go back one more.
  161. last_path_component = path_components[-2]
  162. if last_path_component != self.arch:
  163. raise RuntimeError('To call deployed MATLAB code on a {0} machine, you must run a {0} version of Python. Details: {1}'.format(
  164. last_path_component, path_found))
  165. matlabroot = os.path.dirname(os.path.dirname(os.path.normpath(path_found)))
  166. bin_dir = os.path.join(matlabroot, 'bin', self.arch)
  167. runtime_dir = os.path.join(matlabroot, 'toolbox', 'compiler_sdk', 'pysdk_py')
  168. ml_dir = os.path.join(runtime_dir, 'mlarray_dist')
  169. if not os.path.isdir(bin_dir):
  170. raise RuntimeError('Could not find the directory {0}'.format(bin_dir))
  171. if not os.path.isdir(runtime_dir):
  172. raise RuntimeError('Could not find the directory {0}'.format(runtime_dir))
  173. if not os.path.isdir(ml_dir):
  174. raise RuntimeError('Could not find the directory {0}'.format(ml_dir))
  175. (self.bin_dir, self.runtime_dir, self.ml_dir) = (bin_dir, runtime_dir, ml_dir)
  176. def update_paths(self):
  177. """Update the OS and Python paths."""
  178. #For Windows, add the bin_dir to the OS path. This is unnecessary
  179. #for Linux and Mac, where the OS can find this information via rpath.
  180. if self.is_windows:
  181. os.environ[self.path_var] = self.bin_dir + os.pathsep + os.environ[self.path_var]
  182. #Add all paths to the Python path.
  183. sys.path.insert(0, self.bin_dir)
  184. sys.path.insert(0, self.runtime_dir)
  185. sys.path.insert(0, self.ml_dir)
  186. def import_matlab_pysdk_runtime(self):
  187. """Import matlab_pysdk.runtime. Must be done after update_paths() and import_cppext() are called."""
  188. try:
  189. self.mr_handle = importlib.import_module('matlab_pysdk.runtime')
  190. except Exception as e:
  191. raise e
  192. if not hasattr(self.mr_handle, '_runtime_version_w_dots'):
  193. raise RuntimeError('Runtime version of package ({0}) does not match runtime version of previously loaded package'.format(
  194. _PathInitializer.RUNTIME_VERSION_W_DOTS))
  195. elif self.mr_handle._runtime_version_w_dots and (self.mr_handle._runtime_version_w_dots != _PathInitializer.RUNTIME_VERSION_W_DOTS):
  196. raise RuntimeError('Runtime version of package ({0}) does not match runtime version of previously loaded package ({1})'.format(
  197. _PathInitializer.RUNTIME_VERSION_W_DOTS,
  198. self.mr_handle._runtime_version_w_dots))
  199. else:
  200. self.mr_handle._runtime_version_w_dots = _PathInitializer.RUNTIME_VERSION_W_DOTS
  201. self.mr_handle._cppext_handle = self.cppext_handle
  202. def import_matlab(self):
  203. """Import the matlab package. Must be done after Python system path contains what it needs to."""
  204. try:
  205. self.ml_handle = importlib.import_module('matlab')
  206. except Exception as e:
  207. raise e
  208. def initialize_package(self):
  209. package_handle = self.mr_handle.DeployablePackage(self, self.PACKAGE_NAME, __file__)
  210. self.instances_of_this_package.add(weakref.ref(package_handle))
  211. package_handle.initialize()
  212. return package_handle
  213. def initialize_runtime(self, option_list):
  214. if not self.cppext_handle:
  215. raise RuntimeError('Cannot call initialize_application before import_cppext.')
  216. if self.is_mac:
  217. ignored_option_found = False
  218. for option in option_list:
  219. if option in ('-nodisplay', '-nojvm'):
  220. ignored_option_found = True
  221. break
  222. if ignored_option_found:
  223. print('WARNING: Options "-nodisplay" and "-nojvm" are ignored on Mac.')
  224. print('They must be passed to mwpython in order to take effect.')
  225. self.cppext_handle.initializeApplication(option_list)
  226. def terminate_runtime(self):
  227. if not self.cppext_handle:
  228. raise RuntimeError('Cannot call terminate_application before import_cppext.')
  229. self.cppext_handle.terminateApplication()
  230. def import_cppext(self):
  231. self.cppext_handle = importlib.import_module("matlabruntimeforpython" + self.interpreter_version)
  232. try:
  233. _pir = _PathInitializer()
  234. _pir.get_paths_from_os()
  235. _pir.update_paths()
  236. _pir.import_cppext()
  237. _pir.import_matlab_pysdk_runtime()
  238. _pir.import_matlab()
  239. except Exception as e:
  240. print("Exception caught during initialization of Python interface. Details: {0}".format(e))
  241. raise
  242. # We let the program exit normally.
  243. def initialize():
  244. """
  245. Initialize package and return a handle.
  246. Initialize a package consisting of one or more deployed MATLAB functions. The return
  247. value is used as a handle on which any of the functions can be executed. To wait
  248. for all graphical figures to close before continuing, call wait_for_figures_to_close()
  249. on the handle. To close the package, call terminate(), quit() or exit() (which are
  250. synonymous) on the handle. The terminate() function is executed automatically when the
  251. script or session ends.
  252. Returns
  253. handle - used to execute deployed MATLAB functions and to call terminate()
  254. """
  255. return _pir.initialize_package()
  256. def initialize_runtime(option_list):
  257. """
  258. Initialize runtime with a list of startup options.
  259. Initialize the MATLAB Runtime with a list of startup options that will affect
  260. all packages opened within the script or session. If it is not called
  261. explicitly, it will be executed automatically, with an empty list of options,
  262. by the first call to initialize(). Do not call initialize_runtime() after
  263. calling initialize().
  264. There is no corresponding terminate_runtime() call. The runtime is terminated
  265. automatically when the script or session ends.
  266. Parameters
  267. option_list - Python list of options; valid options are:
  268. -nodisplay (suppresses display functionality; Linux only)
  269. -nojvm (disables the Java Virtual Machine)
  270. """
  271. if option_list:
  272. if not isinstance(option_list, list) and not isinstance(option_list, tuple):
  273. raise SyntaxError('initialize_runtime takes a list or tuple of strings.')
  274. _pir.initialize_runtime(option_list)
  275. # terminate_runtime() is intentionally omitted. Instead, when running interactively,
  276. # the user should call exit(). When running a script, the runtime will automatically be
  277. # terminated when the script ends.
  278. @atexit.register
  279. def __exit_packages():
  280. for package in _pir.instances_of_this_package:
  281. if package() is not None:
  282. package().terminate()

__init__.py at commit 6537096, under Apache-2.0 · at the source

Overview

Authors: Da Wang1,2, Hui Li1, Jinggui Gao3, Yifan Zeng1,2, Mengyang Xu1,2,4,5, Binshi Bo6, Mengchao Pei6, Zhifeng Liang6, Ning Zhou1, Garth J. Thompson1,7
  1. iHuman Institute, ShanghaiTech University, Shanghai, China
  2. School of Life Science and Technology, ShanghaiTech University, Shanghai, China
  3. Department of Neurology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China
  4. Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
  5. University of Chinese Academy of Sciences, Beijing, China
  6. CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China
  7. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China
Journal: Frontiers in neuroscience, volume 20, article 1949911
Dates: received 27 July 2026; accepted 17 September 2026; published online 9 October 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI · PMCID PMC13690678
Status: code verified (how the code is found and verified)
Categories: fMRI (modality), histology / microscopy (modality), human (organism), mouse (organism)
Methods: Spectral & time-frequency, Statistics, Smoothing, state filtering, decompositions, Preprocessing, Connectivity, Graphs, fMRI & imaging, Single-unit activity, calcium imaging
Keywords: calibrated fMRI, cerebral energy efficiency, CMRO2, relative cost, relative power
Citations: not cited yet (Europe PMC); 74 references in the paper

Abstract

Introduction: Non-invasive imaging of brain function and energy supply is crucial for diagnosing and treating brain disorders. Conventional imaging struggles to capture altered relationships between energy supply and demand caused by brain diseases. A novel method, thus far only tested non-invasively in human subjects, is to calculate relative power (rPWR) and relative cost (rCST) to assess cerebral energy efficiency. However, whether rPWR/rCST tracks individual changes and relate to neural activity remains unproven.

Methods: Our study examines awake and anesthetized male mice and compares rPWR/rCST with invasive two-photon microscopy.

Results: We found that rPWR/rCST distributions were similar between awake mice and humans, but changed in anesthetized mice, indicating a shift in the brain’s economic balance. Furthermore, changes in rPWR/rCST were linked to the reorganization of microscopic neural networks, observed with two-photon microscopy.

Discussion: Our work highlights the potential of rPWR/rCST for medical applications, and that neural network reorganization is linked to the brain’s economic balance.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repository

Its files are read in the Code ↔ Paper reader above.

soltanianzadeh/STNeuroNet

License: Apache-2.0
State: the link answers, verified on 24 October 2026
Evidence: files inventoried
Commit: 6537096d8b2c05858320703418e2a3e2897be928, 12 September 2019
Languages: MATLAB (40), Python (17)
Size: 218 files, 57 scripts
Software Heritage: not archived
Found in: the end of the paper
Holds: README, license file, environment (environment.yml, Python Pkg/for_redistribution_files_only/Linux/setup.py, Python Pkg/for_redistribution_files_only/Windows10/setup.py)
Not found: CITATION.cff, tests, continuous integration, documentation
Tools: Image Processing Toolbox (22 files), NumPy (9 files), SciPy (6 files), TensorFlow (6 files), Signal Processing Toolbox (2 files), Statistics and Machine Learning Toolbox (2 files), Matplotlib (2 files), Optimization Toolbox (1 file)
Availability: 1 check, the latest on 24 October 2026: the link answers
  • 24 October 2026: the link answers
59 files

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 57 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data availability statement

The original contributions presented in the study are included in the article/Supplementary material, further inquiries can be directed to the corresponding authors.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 24 October 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 10 authors, 5 keywords, 73 references.

Cite

This paper

Wang, D., Li, H., Gao, J., Zeng, Y., Xu, M., Bo, B., Pei, M., Liang, Z., Zhou, N., & Thompson, G. J. (2026). Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice. Frontiers in neuroscience, 20, 1949911.

BibTeX

@article{wang2026macroscopic,
author = {Wang, Da and Li, Hui and Gao, Jinggui and Zeng, Yifan and Xu, Mengyang and Bo, Binshi and Pei, Mengchao and Liang, Zhifeng and Zhou, Ning and Thompson, Garth J.},
title = {{Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice}},
journal = {Frontiers in neuroscience},
year = {2026},
month = oct,
volume = {20},
pages = {1949911},
publisher = {Frontiers Media SA},
issn = {1662-4548},
pmcid = {PMC13690678}
}

RIS

TY - JOUR
AU - Wang, Da
AU - Li, Hui
AU - Gao, Jinggui
AU - Zeng, Yifan
AU - Xu, Mengyang
AU - Bo, Binshi
AU - Pei, Mengchao
AU - Liang, Zhifeng
AU - Zhou, Ning
AU - Thompson, Garth J.
TI - Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice
T2 - Frontiers in neuroscience
J2 - Front Neurosci
PY - 2026
DA - 2026/10/24
VL - 20
SP - 1949911
SN - 1662-4548
PB - Frontiers Media SA
LA - en
ER -

CSL-JSON

{
"id": "pmcid:PMC13690678",
"type": "article-journal",
"title": "Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice",
"container-title": "Frontiers in neuroscience",
"author": [
{
"family": "Wang",
"given": "Da"
},
{
"family": "Li",
"given": "Hui"
},
{
"family": "Gao",
"given": "Jinggui"
},
{
"family": "Zeng",
"given": "Yifan"
},
{
"family": "Xu",
"given": "Mengyang"
},
{
"family": "Bo",
"given": "Binshi"
},
{
"family": "Pei",
"given": "Mengchao"
},
{
"family": "Liang",
"given": "Zhifeng"
},
{
"family": "Zhou",
"given": "Ning"
},
{
"family": "Thompson",
"given": "Garth J."
}
],
"container-title-short": "Front Neurosci",
"volume": "20",
"page": "1949911",
"PMCID": "PMC13690678",
"ISSN": "1662-4548",
"publisher": "Frontiers Media SA",
"language": "en",
"issued": {
"date-parts": [
[
2026,
10,
24
]
]
}
}

The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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[![OSCR](https://openscicode.org/badge/repo/github.com/soltanianzadeh/stneuronet.svg)](https://openscicode.org/badge/repo/github.com/soltanianzadeh/stneuronet)
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   :alt: OSCR

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