Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice
Paper
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The authors' code
Python · 334 lines · 14 KB · Apache-2.0
- #Copyright 2015-2017 MathWorks, Inc.
- # This template is used to generate an __init__.py file for a particular deployable package.
- """ Package for executing deployed MATLAB functions """
- from __future__ import print_function
- import atexit
- import glob
- import importlib
- import os
- import os.path
- import pdb
- import platform
- import sys
- import weakref
- class _PathInitializer(object):
- PLATFORM_DICT = {'Windows': ['PATH','dll',''], 'Linux': ['LD_LIBRARY_PATH','so','libmw'], 'Darwin': ['DYLD_LIBRARY_PATH','dylib','libmw']}
- SUPPORTED_PYTHON_VERSIONS = ['2_7', '3_4', '3_5', '3_6']
- RUNTIME_VERSION_W_DOTS = '9.3'
- RUNTIME_VERSION_W_UNDERSCORES = '9_3'
- PACKAGE_NAME = 'STNeuroNetPkg'
- def set_interpreter_version(self):
- """Make sure the interpreter version is supported."""
- ver = sys.version_info
- version = '{0}_{1}'.format(ver[0], ver[1])
- if version in _PathInitializer.SUPPORTED_PYTHON_VERSIONS:
- self.interpreter_version = version
- else:
- version_with_dot = version.replace("_", ".")
- raise EnvironmentError("Python {0} is not supported.".format(version_with_dot))
- def __init__(self):
- """Initialize the variables."""
- self.arch = ''
- self.is_linux = False
- self.is_mac = False
- self.is_windows = False
- self.mr_handle = None
- self.ml_handle = None
- self.system = ''
- self.cppext_handle = None
- # path to the folder that stores Python extensions and shared libraries
- self.bin_dir = ''
- # path to the folder that stores pure Python matlab_pysdk.runtime code (_runtime_dir)
- self.runtime_dir = ''
- # path to the folder that stores the pure Python matlab mlarray code used for type conversion
- self.ml_dir = ''
- self.set_interpreter_version()
- self.get_platform_info()
- this_folder = os.path.dirname(os.path.realpath(__file__))
- self.path_file_name = os.path.join(this_folder, 'paths.{0}.txt'.format(self.arch))
- self.instances_of_this_package = set([])
- def read_path_file(self):
- """Look for a file that lists items to add to path. If present, read it and add the paths."""
- filtered_lines = []
- if os.path.isfile(self.path_file_name):
- pth_file = open(self.path_file_name, 'r')
- lines = pth_file.readlines()
- for line in lines:
- stripped_line = line.strip()
- if stripped_line and stripped_line[0] != '#':
- filtered_lines.append(stripped_line)
- length = len(filtered_lines)
- if length == 3:
- (bin_dir, runtime_dir, ml_dir) = filtered_lines
- if (not os.path.isdir(bin_dir)) or (not os.path.isdir(runtime_dir)) or (not os.path.isdir(ml_dir)):
- return False
- else:
- (self.bin_dir, self.runtime_dir, self.ml_dir) = (bin_dir, runtime_dir, ml_dir)
- return True
- else:
- return False
- def write_path_file(self):
- """Write a file that lists items to add to path. If present, it will be overwritten."""
- existing_contents = ''
- if os.path.isfile(self.path_file_name):
- path_file = open(self.path_file_name, 'r')
- existing_contents = path_file.readlines()
- path_file.close()
- path_file = open(self.path_file_name, 'w')
- if self.system == 'Windows':
- print('# bin dir: added to both OS path and system path', file=path_file)
- else:
- print('# bin dir: added to system path', file=path_file)
- print(self.bin_dir, file=path_file)
- print('', file=path_file)
- print('# runtime dir: added to system path', file=path_file)
- print(self.runtime_dir, file=path_file)
- print('', file=path_file)
- print('# matlab (mlarray) dir: added to system path', file=path_file)
- print(self.ml_dir, file=path_file)
- print('', file=path_file)
- if existing_contents:
- print(existing_contents, file=path_file)
- path_file.close()
- def get_platform_info(self):
- """Ask Python for the platform and architecture."""
- # This will return 'Windows', 'Linux', or 'Darwin' (for Mac).
- self.system = platform.system()
- if not self.system in _PathInitializer.PLATFORM_DICT:
- raise RuntimeError('{0} is not a supported platform.'.format(self.system))
- else:
- # path_var is the OS-dependent name of the path variable ('PATH', 'LD_LIBRARY_PATH', "DYLD_LIBRARY_PATH')
- (self.path_var, self.ext, self.lib_prefix) = _PathInitializer.PLATFORM_DICT[self.system]
- if self.system == 'Windows':
- self.is_windows = True
- bit_str = platform.architecture()[0]
- if bit_str == '64bit':
- self.arch = 'win64'
- elif bit_str == '32bit':
- self.arch = 'win32'
- else:
- raise RuntimeError('{0} is not supported.'.format(bit_str))
- elif self.system == 'Linux':
- self.is_linux = True
- self.arch = 'glnxa64'
- elif self.system == 'Darwin':
- self.is_mac = True
- self.arch = 'maci64'
- else:
- raise RuntimeError('Operating system {0} is not supported.'.format(self.system))
- def get_paths_from_os(self):
- """
- Look through the system path for a file whose name contains a runtime version
- corresponding to the one with which this package was produced.
- """
- # Concatenates the pieces into a string. The double parentheses are necessary.
- if self.system == 'Windows':
- file_to_find = ''.join((self.lib_prefix, 'mclmcrrt',
- _PathInitializer.RUNTIME_VERSION_W_UNDERSCORES, '.', self.ext))
- elif self.system == 'Linux':
- file_to_find = ''.join((self.lib_prefix, 'mclmcrrt', '.', self.ext, '.',
- _PathInitializer.RUNTIME_VERSION_W_DOTS))
- elif self.system == 'Darwin':
- file_to_find = ''.join((self.lib_prefix, 'mclmcrrt', '.',
- _PathInitializer.RUNTIME_VERSION_W_DOTS,
- '.', self.ext))
- else:
- raise RuntimeError('Operating system {0} is not supported.'.format(self.system))
- path_elements = []
- if self.path_var in os.environ:
- path_elements = os.environ[self.path_var].split(os.pathsep)
- if not path_elements:
- friendly_os_name = self.system
- if friendly_os_name == 'Darwin':
- friendly_os_name = 'Mac'
- raise RuntimeError('On {0}, you must set the environment variable "{1}" to a non-empty string. {2}'.format(
- friendly_os_name, self.path_var, 'For more details, see the package documentation.'))
- path_found = ''
- for elem in path_elements:
- filename = os.path.join(elem, file_to_find)
- if (os.path.isfile(filename)):
- path_found = elem
- break
- if not path_found:
- raise RuntimeError('Could not find an appropriate directory for MATLAB or the MATLAB runtime in {0}. Details: {1}'.format(
- self.path_var, file_to_find))
- # The last nonblank part of the path should be the arch (e.g., "win64").
- path_components = path_found.split(os.sep)
- if path_components[-1]:
- last_path_component = path_components[-1]
- else:
- # The directory name ended with a slash, so the last item in the list was an empty string. Go back one more.
- last_path_component = path_components[-2]
- if last_path_component != self.arch:
- raise RuntimeError('To call deployed MATLAB code on a {0} machine, you must run a {0} version of Python. Details: {1}'.format(
- last_path_component, path_found))
- matlabroot = os.path.dirname(os.path.dirname(os.path.normpath(path_found)))
- bin_dir = os.path.join(matlabroot, 'bin', self.arch)
- runtime_dir = os.path.join(matlabroot, 'toolbox', 'compiler_sdk', 'pysdk_py')
- ml_dir = os.path.join(runtime_dir, 'mlarray_dist')
- if not os.path.isdir(bin_dir):
- raise RuntimeError('Could not find the directory {0}'.format(bin_dir))
- if not os.path.isdir(runtime_dir):
- raise RuntimeError('Could not find the directory {0}'.format(runtime_dir))
- if not os.path.isdir(ml_dir):
- raise RuntimeError('Could not find the directory {0}'.format(ml_dir))
- (self.bin_dir, self.runtime_dir, self.ml_dir) = (bin_dir, runtime_dir, ml_dir)
- def update_paths(self):
- """Update the OS and Python paths."""
- #For Windows, add the bin_dir to the OS path. This is unnecessary
- #for Linux and Mac, where the OS can find this information via rpath.
- if self.is_windows:
- os.environ[self.path_var] = self.bin_dir + os.pathsep + os.environ[self.path_var]
- #Add all paths to the Python path.
- sys.path.insert(0, self.bin_dir)
- sys.path.insert(0, self.runtime_dir)
- sys.path.insert(0, self.ml_dir)
- def import_matlab_pysdk_runtime(self):
- """Import matlab_pysdk.runtime. Must be done after update_paths() and import_cppext() are called."""
- try:
- self.mr_handle = importlib.import_module('matlab_pysdk.runtime')
- except Exception as e:
- raise e
- if not hasattr(self.mr_handle, '_runtime_version_w_dots'):
- raise RuntimeError('Runtime version of package ({0}) does not match runtime version of previously loaded package'.format(
- _PathInitializer.RUNTIME_VERSION_W_DOTS))
- elif self.mr_handle._runtime_version_w_dots and (self.mr_handle._runtime_version_w_dots != _PathInitializer.RUNTIME_VERSION_W_DOTS):
- raise RuntimeError('Runtime version of package ({0}) does not match runtime version of previously loaded package ({1})'.format(
- _PathInitializer.RUNTIME_VERSION_W_DOTS,
- self.mr_handle._runtime_version_w_dots))
- else:
- self.mr_handle._runtime_version_w_dots = _PathInitializer.RUNTIME_VERSION_W_DOTS
- self.mr_handle._cppext_handle = self.cppext_handle
- def import_matlab(self):
- """Import the matlab package. Must be done after Python system path contains what it needs to."""
- try:
- self.ml_handle = importlib.import_module('matlab')
- except Exception as e:
- raise e
- def initialize_package(self):
- package_handle = self.mr_handle.DeployablePackage(self, self.PACKAGE_NAME, __file__)
- self.instances_of_this_package.add(weakref.ref(package_handle))
- package_handle.initialize()
- return package_handle
- def initialize_runtime(self, option_list):
- if not self.cppext_handle:
- raise RuntimeError('Cannot call initialize_application before import_cppext.')
- if self.is_mac:
- ignored_option_found = False
- for option in option_list:
- if option in ('-nodisplay', '-nojvm'):
- ignored_option_found = True
- break
- if ignored_option_found:
- print('WARNING: Options "-nodisplay" and "-nojvm" are ignored on Mac.')
- print('They must be passed to mwpython in order to take effect.')
- self.cppext_handle.initializeApplication(option_list)
- def terminate_runtime(self):
- if not self.cppext_handle:
- raise RuntimeError('Cannot call terminate_application before import_cppext.')
- self.cppext_handle.terminateApplication()
- def import_cppext(self):
- self.cppext_handle = importlib.import_module("matlabruntimeforpython" + self.interpreter_version)
- try:
- _pir = _PathInitializer()
- _pir.get_paths_from_os()
- _pir.update_paths()
- _pir.import_cppext()
- _pir.import_matlab_pysdk_runtime()
- _pir.import_matlab()
- except Exception as e:
- print("Exception caught during initialization of Python interface. Details: {0}".format(e))
- raise
- # We let the program exit normally.
- def initialize():
- """
- Initialize package and return a handle.
- Initialize a package consisting of one or more deployed MATLAB functions. The return
- value is used as a handle on which any of the functions can be executed. To wait
- for all graphical figures to close before continuing, call wait_for_figures_to_close()
- on the handle. To close the package, call terminate(), quit() or exit() (which are
- synonymous) on the handle. The terminate() function is executed automatically when the
- script or session ends.
- Returns
- handle - used to execute deployed MATLAB functions and to call terminate()
- """
- return _pir.initialize_package()
- def initialize_runtime(option_list):
- """
- Initialize runtime with a list of startup options.
- Initialize the MATLAB Runtime with a list of startup options that will affect
- all packages opened within the script or session. If it is not called
- explicitly, it will be executed automatically, with an empty list of options,
- by the first call to initialize(). Do not call initialize_runtime() after
- calling initialize().
- There is no corresponding terminate_runtime() call. The runtime is terminated
- automatically when the script or session ends.
- Parameters
- option_list - Python list of options; valid options are:
- -nodisplay (suppresses display functionality; Linux only)
- -nojvm (disables the Java Virtual Machine)
- """
- if option_list:
- if not isinstance(option_list, list) and not isinstance(option_list, tuple):
- raise SyntaxError('initialize_runtime takes a list or tuple of strings.')
- _pir.initialize_runtime(option_list)
- # terminate_runtime() is intentionally omitted. Instead, when running interactively,
- # the user should call exit(). When running a script, the runtime will automatically be
- # terminated when the script ends.
- @atexit.register
- def __exit_packages():
- for package in _pir.instances_of_this_package:
- if package() is not None:
- package().terminate()
__init__.py at commit 6537096, under Apache-2.0 · at the source
Overview
- iHuman Institute, ShanghaiTech University, Shanghai, China
- School of Life Science and Technology, ShanghaiTech University, Shanghai, China
- Department of Neurology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China
- Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
- University of Chinese Academy of Sciences, Beijing, China
- CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China
- School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China
Abstract
Introduction: Non-invasive imaging of brain function and energy supply is crucial for diagnosing and treating brain disorders. Conventional imaging struggles to capture altered relationships between energy supply and demand caused by brain diseases. A novel method, thus far only tested non-invasively in human subjects, is to calculate relative power (rPWR) and relative cost (rCST) to assess cerebral energy efficiency. However, whether rPWR/
Methods: Our study examines awake and anesthetized male mice and compares rPWR/
Results: We found that rPWR/
Discussion: Our work highlights the potential of rPWR/
Reproduced under the paper's license (CC BY), from the paper cited above.
Repository
Its files are read in the Code ↔ Paper reader above.
soltanianzadeh/STNeuroNet
6537096d8b2c05858320703418e2a3e2897be928, 12 September 2019Availability: 1 check, the latest on 24 October 2026: the link answers
- 24 October 2026: the link answers
59 files
- Python Pkg/
for_redistribution_files , Python, 334 lines_only/ Linux/ STNeuroNetPkg/ __init__.py - Python Pkg/
for_redistribution_files , Python, 34 lines_only/ Linux/ setup.py - Python Pkg/
for_redistribution_files , Python, 334 lines_only/ Windows10/ STNeuroNetPkg/ __init__.py - Python Pkg/
for_redistribution_files , Python, 34 lines_only/ Windows10/ setup.py - RunLayer175.py, Python, 204 lines
- RunLayer275.py, Python, 209 lines
- RunThresh.py, Python, 175 lines
- Software/
GetPerformance_Jaccard.m , MATLAB, 51 lines - Software/
Manual labeling GUI/ , MATLAB, 210 linesAddROI.m - Software/
Manual labeling GUI/ , MATLAB, 474 linesSelectNeuron_Allen.m - Software/
Postprocessing functions/ , MATLAB, 32 linesCompleteSeparate.m - Software/
Postprocessing functions/ , MATLAB, 280 linesHungarian.m - Software/
Postprocessing functions/ , MATLAB, 25 linesJaccardDist.m - Software/
Postprocessing functions/ , MATLAB, 30 linescheckSegments.m - Software/
Postprocessing functions/ , MATLAB, 121 linesmatchCenters.m - Software/
Postprocessing functions/ , MATLAB, 60 linesseparateNeuronsWT.m - Software/
Postprocessing functions/ , MATLAB, 210 linesuniqueNeurons.m - Software/
STNeuroNet/ , Python, 435 linesapplication_driver.py - Software/
STNeuroNet/ , Python, 252 linesapplication_factory.py - Software/
STNeuroNet/ , Python, 677 linesgrid_warper.py - Software/
STNeuroNet/ , Python, 89 linespad.py - Software/
STNeuroNet/ , Python, 310 linessegmentation_application .py - Software/
STNeuroNet/ , Python, 355 linesstneuronet.py - Software/
STNeuroNet/ , Python, 107 lineswindows_aggregator_grid. py - Software/
Viewing functions/ , MATLAB, 65 linesRunViewMarking.m - Software/
Viewing functions/ , MATLAB, 73 linesViewAllenMarking.m - Software/
Viewing functions/ , MATLAB, 159 linesViewFullFOV.m - Software/
Viewing functions/ , MATLAB, 56 linesViewNeuronMarking.m - Software/
Viewing functions/ , MATLAB, 384 linesViewNeurons.m - Software/
main_SelectNeuron.m , MATLAB, 77 lines - Software/
multiple_postProcessJacc , MATLAB, 49 linesard.m - Software/
postProcess.m , MATLAB, 42 lines - Software/
prepareAllen.m , MATLAB, 48 lines - Software/
prepareNeurofinder.m , MATLAB, 55 lines - Software/
utility functions/ , MATLAB, 37 linesGetTraces.m - Software/
utility functions/ , MATLAB, 68 linesHomoFilt_Normalize.m - Software/
utility functions/ , MATLAB, 22 linesMaskCOM.m - Software/
utility functions/ , MATLAB, 63 linesRemoveNeuropil.m - Software/
utility functions/ , MATLAB, 39 linesSaveSubVolumes.m - Software/
utility functions/ , MATLAB, 98 linesTemporalLabeling_d.m - Software/
utility functions/ , MATLAB, 19 linesbinTraces_temporal.m - Software/
utility functions/ , MATLAB, 18 linesbinVideo_temporal.m - Software/
utility functions/ , MATLAB, 60 linescorrelation_img.m - Software/
utility functions/ , MATLAB, 68 linesdemixTraces.m - Software/
utility functions/ , MATLAB, 63 linesdemixTraces_small.m - Software/
utility functions/ , MATLAB, 21 lineshomo_filt.m - Software/
utility functions/ , MATLAB, 99 linesnormalizeValues.m - Software/
utility functions/ , MATLAB, 67 linesprepareTemporalMask.m - Software/
utility functions/ , MATLAB, 57 linesrandWinSave.m - demo_ManualLabeling.m, MATLAB, 16 lines
- demo_inference.py, Python, 175 lines
- demo_inference_neurofind
er.py , Python, 251 lines - demo_optThresh.m, MATLAB, 41 lines
- demo_postprocess.m, MATLAB, 33 lines
- demo_preprocess.m, MATLAB, 51 lines
- demo_train.py, Python, 228 lines
- view_marking.m, MATLAB, 39 lines
- LICENSE, License, 201 lines
- README.md, Text, 78 lines
Tracing map
Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.
What the map holds:
- 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
- 57 scripts, each with its path and the digest of its content;
- no match between paragraphs and code yet;
- neither the text of the paper nor the code itself.
Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.
Data
No dataset and no data link were found in the paper.
Data availability statement
The original contributions presented in the study are included in the article/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 24 October 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 10 authors, 5 keywords, 73 references.
Cite
This paper
Wang, D., Li, H., Gao, J., Zeng, Y., Xu, M., Bo, B., Pei, M., Liang, Z., Zhou, N., & Thompson, G. J. (2026). Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice. Frontiers in neuroscience, 20, 1949911.
BibTeX
@article{wang2026macrosc
author = {Wang, Da and Li, Hui and Gao, Jinggui and Zeng, Yifan and Xu, Mengyang and Bo, Binshi and Pei, Mengchao and Liang, Zhifeng and Zhou, Ning and Thompson, Garth J.},
title = {{Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice}},
journal = {Frontiers in neuroscience},
year = {2026},
month = oct,
volume = {20},
pages = {1949911},
publisher = {Frontiers Media SA},
issn = {1662-4548},
pmcid = {PMC13690678}
}
RIS
TY - JOUR
AU - Wang, Da
AU - Li, Hui
AU - Gao, Jinggui
AU - Zeng, Yifan
AU - Xu, Mengyang
AU - Bo, Binshi
AU - Pei, Mengchao
AU - Liang, Zhifeng
AU - Zhou, Ning
AU - Thompson, Garth J.
TI - Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice
T2 - Frontiers in neuroscience
J2 - Front Neurosci
PY - 2026
DA - 2026/
VL - 20
SP - 1949911
SN - 1662-4548
PB - Frontiers Media SA
LA - en
ER -
CSL-JSON
{
"id": "pmcid:PMC13690678",
"type": "article-journal",
"title": "Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice",
"container-title": "Frontiers in neuroscience",
"author": [
{
"family": "Wang",
"given": "Da"
},
{
"family": "Li",
"given": "Hui"
},
{
"family": "Gao",
"given": "Jinggui"
},
{
"family": "Zeng",
"given": "Yifan"
},
{
"family": "Xu",
"given": "Mengyang"
},
{
"family": "Bo",
"given": "Binshi"
},
{
"family": "Pei",
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},
{
"family": "Liang",
"given": "Zhifeng"
},
{
"family": "Zhou",
"given": "Ning"
},
{
"family": "Thompson",
"given": "Garth J."
}
],
"container-title-short":
"volume": "20",
"page": "1949911",
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"publisher": "Frontiers Media SA",
"language": "en",
"issued": {
"date-parts": [
[
2026,
10,
24
]
]
}
}
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You validate the map as this page shows it: 1 repository of the authors' code, each at its verified commit and with its license, 57 scripts, and 0 matches between paragraphs and code (see the Code and Map sections). It then receives a DOI on Zenodo, with you (your ORCID iD) and OSCR as its creators; the code itself is not deposited.
The map's fingerprint: sha256:33dbd9c9d362764f…
Add the badge to the code's README
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Markdown
<!-- oscr-badge:start -->
[](https://openscicode.org/badge/repo/github.com/soltanianzadeh/stneuronet)
<!-- oscr-badge:end -->reStructuredText
.. oscr-badge:start
.. image:: https://openscicode.org/badge/repo/github.com/soltanianzadeh/stneuronet.svg
:target: https://openscicode.org/badge/repo/github.com/soltanianzadeh/stneuronet
:alt: OSCR
.. oscr-badge:endHTML
<!-- oscr-badge:start -->
<a href="https://openscicode.org/badge/repo/github.com/soltanianzadeh/stneuronet"><img src="https://openscicode.org/badge/repo/github.com/soltanianzadeh/stneuronet.svg" alt="OSCR"></a>
<!-- oscr-badge:end -->On GitHub, open the README, choose Edit (the pencil), paste the snippet under the title, then "Commit changes".
If you choose to, you can have the badge kept up to date for you, with oscr badge --write from the command line or with the GitHub Action in your repository's workflows. Every other form and option (a card, AsciiDoc, LaTeX, shields.io) is on the badge page.
Request its removal
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Discussion, reproductions, activity
Discussion: code errors and mismatches between the code and the paper about this paper and its code, from readers and its authors, beside the paper and its tracing map.
Report a mismatch between the code and the paper · Report a code error (signed in)
Reproductions: reports from readers who ran the authors' code and did not get the paper's result, what they ran, with which environment, commit and data.
Report a reproduction failure (signed in)
Versions of its code: the releases of its code tied to a version of this paper (the preprint, the accepted manuscript, the version of record…), each with the tracing map versioned with it.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.
