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Neuid: A Novel Neuron-Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease.

Overview

Authors: Ranjit Pradhan1, Zorica Petrovic2, M Sadman Sakib1, Sophie Schröder1, Dennis Manfred Krüger1,3, Tonatiuh Pena1,3, Eren Diniz1, Susanne Burkhardt1, Anna‐Lena Schütz4, Verena Gisa1, Iga Grzadzielewska1, Karl Toischer5,6,7, Thor D Stein8,9,10,11, Jan Krzysztof Blusztajn8,11, Ivana Delalle8,11, Jelena Radulovic12,13, Farahnaz Sananbenesi3,4, Andre Fischer5,6,14
ORCID iDs: Jan Krzysztof Blusztajn, Andre Fischer
14 affiliations
  1. Department For Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany
  2. Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
  3. Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany
  4. Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany
  5. Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, Göttingen, Germany
  6. German Center for Cardiovascular Diseases (DZKH), Göttingen, Germany
  7. Department of Cardiology and Pneumology, Georg‐August‐University, Goettingen, Germany
  8. Department of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA
  9. VA Boston Healthcare System, Boston, Massachusetts, USA
  10. Department of Veterans Affairs Medical Center, Bedford, Massachusetts, USA
  11. Boston University Alzheimer's Disease Research Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA
  12. Department of Biomedicine, Aarhus University, PROMEMO, DANDRITE, Aarhus University, Aarhus, Denmark
  13. Dominick P. Purpura Department of Neuroscience and Department of Psychiatry and Behavioral Sciences, Psychiatry Research Institute Montefiore Einstein (PRIME), Albert Einstein College of Medicine, Bronx, New York, USA
  14. Department For Psychiatry and Psychotherapy, University Medical Center of Göttingen, Georg‐August University, Göttingen, Germany
Institutions: German Center for Neurodegenerative Diseases (Germany); Albert Einstein College of Medicine (United States); Multiscale Bioimaging; University of Göttingen (Germany); Boston University (United States); Edith Nourse Rogers Memorial Veterans Hospital (United States); VA Boston Healthcare System (United States); Aarhus University (Denmark); Universitätsmedizin Göttingen (Germany)
Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany), volume 13, issue 29, article e14972
Dates: received 6 August 2025; accepted 6 March 2026; published online 14 March 2026; in print May 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1002/advs.202514972 · PMID 41831315 · PMCID PMC13205658 · OpenAlex W7135405564
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, fMRI & imaging, Single-unit activity, calcium imaging
Keywords: brain, epigenetics, long‐non‐coding RNA, neurodegeneration, non‐coding RNA
MeSH: Alzheimer Disease*, Epigenesis, Genetic*, Gene Silencing*, Neurons*, RNA, Long Noncoding*, Animals, Brain, Enhancer of Zeste Homolog 2 Protein, Humans, Mice (* major topic)
Topic: Cancer-related molecular mechanisms research (Cancer Research, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: AF is supported by German Ministry and Science and Education (EPI-3E, EPINEURODEVO, GoBIOmiRassay(16LW0055)); NHLBI NIH HHS (HC-25195, HHSN268201500001I, 75N92019D00031, HHSN268201500001, HHSN268201500001C); BLRD VA (I01 BX005933); Veterans Health Administration, BLRD Merit Award (R01MH108837, I01BX005933); JKB is supported by NIH grant (RF1AG078299); NIA NIH HHS (U19 AG068753, R01 AG078299, R01 AG084624, RF1 AG078299, P30 AG072978); NIMH NIH HHS (R01 MH108837); TDS and JKB are supported by NIH grants (P30AG072978, U19AG068753); ID, JKB and TDS are supported by NIH (RF1AG078299)
Citations: not cited yet (Europe PMC); 88 references in the paper

Abstract

The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized. Here, we identify a previously unstudied lncRNA, which we named Neuronal Identity (Neuid), a conserved, brain‐enriched transcript expressed in neurons. Neuid is downregulated in the brains of Alzheimer's disease (AD) patients. Mechanistically, Neuid maintains neuronal identity by repressing developmental and glial genes via interaction with the PRC2 subunit EZH2 and regulation of H3K27me3. Knockdown of Neuid disrupts this repression, leading to impaired neuronal activity and memory formation. Importantly, CRISPRa‐mediated Neuid overexpression restores neuronal function in Aβ42‐treated neurons. These findings identify NeuID as a critical regulator of neuronal plasticity and position it as a promising therapeutic target for AD

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper links to its data, not to its authors' code: see the Data section.

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Data

Datasets cited

Data Availability Statement

RNA Sequencing data is available via GEO accession GSE296334 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296334). ChIP‐seq data is available via GSE296334 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296334). The human snucRNAseq is from (30).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 18 authors, 5 keywords, 10 MeSH terms, 9 funders, 82 references.

Cite

This paper

Pradhan, R., Petrovic, Z., Sadman Sakib, M., Schröder, S., Manfred Krüger, D., Pena, T., Diniz, E., Burkhardt, S., Schütz, A., Gisa, V., Grzadzielewska, I., Toischer, K., Stein, T. D., Blusztajn, J. K., Delalle, I., Radulovic, J., Sananbenesi, F., & Fischer, A. (2026). Neuid: A Novel Neuron-Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 13(29), e14972. https://doi.org/10.1002/advs.202514972

BibTeX

@article{pradhan2026neuid,
author = {Pradhan, Ranjit and Petrovic, Zorica and Sadman Sakib, M and Schröder, Sophie and Manfred Krüger, Dennis and Pena, Tonatiuh and Diniz, Eren and Burkhardt, Susanne and Schütz, Anna‐Lena and Gisa, Verena and Grzadzielewska, Iga and Toischer, Karl and Stein, Thor D and Blusztajn, Jan Krzysztof and Delalle, Ivana and Radulovic, Jelena and Sananbenesi, Farahnaz and Fischer, Andre},
title = {{Neuid: A Novel Neuron-Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease}},
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = mar,
volume = {13},
number = {29},
pages = {e14972},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/advs.202514972},
url = {https://doi.org/10.1002/advs.202514972},
pmid = {41831315},
pmcid = {PMC13205658}
}

RIS

TY - JOUR
AU - Pradhan, Ranjit
AU - Petrovic, Zorica
AU - Sadman Sakib, M
AU - Schröder, Sophie
AU - Manfred Krüger, Dennis
AU - Pena, Tonatiuh
AU - Diniz, Eren
AU - Burkhardt, Susanne
AU - Schütz, Anna‐Lena
AU - Gisa, Verena
AU - Grzadzielewska, Iga
AU - Toischer, Karl
AU - Stein, Thor D
AU - Blusztajn, Jan Krzysztof
AU - Delalle, Ivana
AU - Radulovic, Jelena
AU - Sananbenesi, Farahnaz
AU - Fischer, Andre
TI - Neuid: A Novel Neuron-Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/03/14
VL - 13
IS - 29
SP - e14972
SN - 2198-3844
PB - Wiley
DO - 10.1002/advs.202514972
UR - https://doi.org/10.1002/advs.202514972
LA - en
ER -

CSL-JSON

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