A Brain-Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior.
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- [1] § Methods › Statistical Analysis ↔ ToolKit/IntraGrpStat.py, lines 14–120 · score 0.73 · Mann Whitney, way ANOVA, equality, variance, Levene, Shapiro
- [2] § Methods › Statistical Analysis ↔ ToolKit/IntraGrpStat_v2_df.py, the whole file · a weak match · score 0.73 · Mann Whitney, way ANOVA, equality, variance, Levene, Shapiro
- [3] § Methods › Ex Vivo Calcium Imaging › Data Analysis ↔ ToolKit/Analysor.py, lines 129–221 · score 0.60 · full width, fitted, HMFW, peaks, rise, decay
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Overview
and 13 other authors
Eva M Eisemann2, Ingrid Camila Possa‐Paranhos2, Cassandra Baumann1, Pierre‐Alexis Derrien1, Quirin Krabichler6, Cosmo Garcia7, Henning Fröhlich2, Matthew K Kirchner7, Valery Grinevich6,8, Pascal Darbon1, Javier E Stern7, Ferdinand Althammer2, Alexandre Charlet1- Centre National de La Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France
- Institute of Human Genetics, Heidelberg University, Heidelberg, Germany
- Center For Neuroscience and Cell Biology CNC‐UC, University of Coimbra, Coimbra, Portugal
- Centre For Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
- Center for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, PSL‐Neuro, Université PSL, Paris, France
- Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, German Center for Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
- Center For Neuroinflammation and Cardiometabolic Diseases, and Neuroscience Institute, Georgia State University, Atlanta, Georgia, USA
- International Joint Laboratory for Translational Research on Neuromodulation, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Abstract
Until recently, it was widely assumed that oxytocin signaling occurred exclusively through the activation of neuronal oxytocin receptors, with neurons being the primary targets of released oxytocin. However, this view was challenged by the discovery of functional oxytocin receptors in central amygdala astrocytes, which are essential for the proper function of local neuronal microcircuits. Since then, astrocytic oxytocin receptors have been implicated in various aspects of rodent physiology and behavior, yet it remains unclear whether this mechanism is region‐specific or widespread across the brain. Here, we provide extensive anatomical data on oxytocin receptor expression in mice and rats, functionally validated through calcium imaging. Based on this mapping and using genetic, calcium imaging and behavioral approaches, we further demonstrate a critical role for oxytocin receptor‐expressing astrocytes in the nucleus accumbens in social behavior. In summary, our findings demonstrate that oxytocin receptors are widely expressed in astrocytes across different brain regions. In the nucleus accumbens, these receptors modulate social behavior—an observation with significant implications for the current model of oxytocinergic modulation in the brain.
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Team-Charlet/Denis_et_al._2026
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Recorded: type, language, journal, volume, issue, pages, dates, 33 authors, 5 keywords, 12 MeSH terms, 9 funders, 50 references.
Cite
This paper
Denis, C., Stojilkovic, S., Wang, K., Márquez, C., Kleinwächter, A. C., Baudon, A., Podpecan, Y., Ces, A., Kremer, M., Arnoux, I., Rouach, N., Helen, J., Trender, S., Wallkum, A., Wunsch, S., Schommer, F., Wimmer, M. C., Schubert, T., Franke, F., . . . Charlet, A. (2026). A Brain-Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 13(46), e18450. https://
BibTeX
@article{denis2026brain,
author = {Denis, Clémence and Stojilkovic, Stefan and Wang, Kai‐Yi and Márquez, Cristina and Kleinwächter, Annabel C and Baudon, Angel and Podpecan, Yuval and Ces, Aurélia and Kremer, Mélanie and Arnoux, Isabelle and Rouach, Nathalie and Helen, Jemima and Trender, Sophie and Wallkum, Andreas and Wunsch, Selina and Schommer, Franziska and Wimmer, Moritz C and Schubert, Tim and Franke, Felix and Muhammad, Jabir Aliyu and Eisemann, Eva M and Possa‐Paranhos, Ingrid Camila and Baumann, Cassandra and Derrien, Pierre‐Alexis and Krabichler, Quirin and Garcia, Cosmo and Fröhlich, Henning and Kirchner, Matthew K and Grinevich, Valery and Darbon, Pascal and Stern, Javier E and Althammer, Ferdinand and Charlet, Alexandre},
title = {{A Brain-Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior}},
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = jun,
volume = {13},
number = {46},
pages = {e18450},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/
url = {https://
pmid = {42237738},
pmcid = {PMC13336011}
}
RIS
TY - JOUR
AU - Denis, Clémence
AU - Stojilkovic, Stefan
AU - Wang, Kai‐Yi
AU - Márquez, Cristina
AU - Kleinwächter, Annabel C
AU - Baudon, Angel
AU - Podpecan, Yuval
AU - Ces, Aurélia
AU - Kremer, Mélanie
AU - Arnoux, Isabelle
AU - Rouach, Nathalie
AU - Helen, Jemima
AU - Trender, Sophie
AU - Wallkum, Andreas
AU - Wunsch, Selina
AU - Schommer, Franziska
AU - Wimmer, Moritz C
AU - Schubert, Tim
AU - Franke, Felix
AU - Muhammad, Jabir Aliyu
AU - Eisemann, Eva M
AU - Possa‐Paranhos, Ingrid Camila
AU - Baumann, Cassandra
AU - Derrien, Pierre‐Alexis
AU - Krabichler, Quirin
AU - Garcia, Cosmo
AU - Fröhlich, Henning
AU - Kirchner, Matthew K
AU - Grinevich, Valery
AU - Darbon, Pascal
AU - Stern, Javier E
AU - Althammer, Ferdinand
AU - Charlet, Alexandre
TI - A Brain-Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/
VL - 13
IS - 46
SP - e18450
SN - 2198-3844
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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