Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone.
Overview
- Buck Institute for Research on Aging Novato California USA
- Department of Orthopaedic Surgery University of California San Francisco California USA
- Department of Anatomy University of California San Francisco California USA
- Bakar Aging Research Institute University of California San Francisco California USA
- Intramural Research Program National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH Bethesda Maryland USA
Abstract
Individuals with Alzheimer's disease (AD) are at an increased risk of bone fracture, while osteoporosis in women is one of the earliest predictors of AD. Yet the mechanisms linking cognitive decline and skeletal deterioration remain poorly defined. Proteomic analysis of cortical bone from aged 21‐month‐old mice revealed strong enrichment of neurodegeneration‐associ
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- bioproject:PRJNA1314782, at NCBI BioProject; found in “Data Availability Statement”
Data Availability
RNAseq data generated from mouse cortical bone enriched in osteocytes are available in the National Center for Biotechnology Information (NCBI) Sequence Read Archive (SRA) under BioProject accession number PRJNA1314782. Raw data and complete MS data sets were uploaded to the Mass Spectrometry Interactive Virtual Environment (MassIVE) repository, developed by the Center for Computational Mass Spectrometry at the University of California San Diego, and can be downloaded using the following link: ftp:// ‐ftp.ucsd.edu (MassIVE ID number: MSV000099018; Proteome Xchange ID: PXD068037)
Reproduced under the paper's license (CC BY), from the paper cited above.
Data Availability Statement
The data that support the findings of this study are openly available. RNAseq: available in the National Center for Biotechnology Information (NCBI) Sequence Read Archive (SRA) under BioProject accession number PRJNA1314782 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 5 keywords, 14 MeSH terms, 4 funders, 139 references.
Cite
This paper
Schurman, C. A., Kaur, G., Kaya, S., Bons, J., Aguirre, C. G., Liu, Q., King, C. D., Wilson, K. A., Baker, H. L., Hady, M., Luna, N. M., Bieri, G., Villeda, S. A., Ellerby, L. M., Schilling, B., & Alliston, T. (2026). Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 13(28), e23511. https://
BibTeX
@article{schurman2026alz
author = {Schurman, Charles A. and Kaur, Gurcharan and Kaya, Serra and Bons, Joanna and Aguirre, Carlos Galicia and Liu, Qi and King, Christina D. and Wilson, Kenneth A. and Baker, Harrison L. and Hady, Mikayla and Luna, Nadja Maldonado and Bieri, Gregor and Villeda, Saul A. and Ellerby, Lisa M. and Schilling, Birgit and Alliston, Tamara},
title = {{Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone}},
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = apr,
volume = {13},
number = {28},
pages = {e23511},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/
url = {https://
pmid = {41972397},
pmcid = {PMC13185828}
}
RIS
TY - JOUR
AU - Schurman, Charles A.
AU - Kaur, Gurcharan
AU - Kaya, Serra
AU - Bons, Joanna
AU - Aguirre, Carlos Galicia
AU - Liu, Qi
AU - King, Christina D.
AU - Wilson, Kenneth A.
AU - Baker, Harrison L.
AU - Hady, Mikayla
AU - Luna, Nadja Maldonado
AU - Bieri, Gregor
AU - Villeda, Saul A.
AU - Ellerby, Lisa M.
AU - Schilling, Birgit
AU - Alliston, Tamara
TI - Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/
VL - 13
IS - 28
SP - e23511
SN - 2198-3844
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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