OSCR

HDL-mimetic peptide treatment reverses APOE4-induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice.

Overview

Authors: Allison Chang1, Minwoo Kim2, Matthew Glittenberg3, Wenhui Qu1, Danni Li1,3, Ling Li1,2
ORCID iDs: Ling Li
  1. Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
  2. Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
  3. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
Institutions: University of Minnesota (United States); University of Minnesota System (United States)
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association, volume 22, issue 6, article e71568
Dates: received 12 January 2026; accepted 4 May 2026; published online 23 June 2026; in print June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/alz.71568 · PMID 42337953 · PMCID PMC13290654 · OpenAlex W7165640123
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), mouse (organism), Alzheimer's / dementia (population), clinical / translational (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Connectivity
Keywords: Alzheimer's disease, APOE, brain, HDL‐mimetic peptide, lipidomics, transcriptomics
MeSH: Apolipoprotein E4*, Brain*, Lipid Metabolism*, Lipoproteins, HDL*, Peptides*, Transcriptome*, Alzheimer Disease, Animals, Apolipoprotein A-I, Apolipoproteins E, Disease Models, Animal, Humans, Lipidomics, Mice, Mice, Transgenic (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: National Institutes of Health (AG081426, AG056976, AG059654, AG058081, AG077772); NIH HHS (AG058081, AG077772, AG059654, AG056976, AG081426); College of Pharmacy, University of Minnesota; NIH training grant (T32AG029796)
Citations: not cited yet (Europe PMC); 86 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Data availability statement

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Read it in the paper: doi.org/10.1002/alz.71568.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 6 keywords, 15 MeSH terms, 4 funders, 86 references.

Cite

This paper

Chang, A., Kim, M., Glittenberg, M., Qu, W., Li, D., & Li, L. (2026). HDL-mimetic peptide treatment reverses APOE4-induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(6), e71568. https://doi.org/10.1002/alz.71568

BibTeX

@article{chang2026hdl,
author = {Chang, Allison and Kim, Minwoo and Glittenberg, Matthew and Qu, Wenhui and Li, Danni and Li, Ling},
title = {{HDL-mimetic peptide treatment reverses APOE4-induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = jun,
volume = {22},
number = {6},
pages = {e71568},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/alz.71568},
url = {https://doi.org/10.1002/alz.71568},
pmid = {42337953},
pmcid = {PMC13290654}
}

RIS

TY - JOUR
AU - Chang, Allison
AU - Kim, Minwoo
AU - Glittenberg, Matthew
AU - Qu, Wenhui
AU - Li, Danni
AU - Li, Ling
TI - HDL-mimetic peptide treatment reverses APOE4-induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/06/01
VL - 22
IS - 6
SP - e71568
SN - 1552-5260
PB - Wiley
DO - 10.1002/alz.71568
UR - https://doi.org/10.1002/alz.71568
LA - en
ER -

CSL-JSON

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"container-title": "Alzheimer's & dementia : the journal of the Alzheimer's Association",
"author": [
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"container-title-short": "Alzheimers Dement",
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"language": "en",
"issued": {
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