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A Neutrophil Membrane-Encapsulated Pd/hCeO<sub>2</sub> Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive Disorders.

Overview

Authors: Lili Huang1,2, Jiahui Cheng3, Huan Xu4, Qiang Zhang5, Xiao Zhang6, Ye Liu6, Yizhe Zhang1,2, Wanbing Dai1,2, Zhi Xiong5, Linghuan Guo5, Lingling Xu3, Wen Wang3, Xin Xu3, Yan Zhou3,7, Weifeng Yu1,2, Bo Li2,3, Diansan Su6, Daxiang Wen1,2
ORCID iDs: Lili Huang, Huan Xu, Qiang Zhang, Xiao Zhang, Yizhe Zhang, Bo Li, Diansan Su
  1. Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai, China
  2. Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Pudong, Shanghai, China
  3. Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai, China
  4. Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Yangpu, Shanghai, China
  5. Institute of Diagnostic and Interventional Radiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Xuhui, Shanghai, China
  6. Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
  7. College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Huangpu, Shanghai, China
Institutions: Shanghai Jiao Tong University (China); Renji Hospital (China); Shanghai Pulmonary Hospital (China); Yangpu Hospital of Tongji University (China); Shanghai Sixth People's Hospital (China); First Affiliated Hospital Zhejiang University (China)
Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany), article e78033
Dates: received 23 April 2026; accepted 19 September 2026; published online 30 September 2026; in print September 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1002/advs.78033 · PMID 42816949 · PMCID PMC13627777 · OpenAlex W7215048254
Open access: gold, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: aging, glucometabolic reprogramming, microglial activation, Pd/hCeO2 nanozyme, perioperative neurocognitive disorder
Topic: Advanced Nanomaterials in Catalysis (Materials Chemistry, Materials Science), according to OpenAlex
Funding: Shanghai Science and Technology Committee Project (24ZR1444600); Fundamental Research Funds for the Central Universities (25X010202804); Sanming Project of Medicine in Shenzhen (SZSM202311003); National Natural Science Foundation of China (U21A20357, 82371223, 82401402, 81970995, 82571349); Funding of First Affiliated Hospital of Zhejiang University, School of Medicine (BQD-2419); Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation (20DZ2254200); Special Fund Project for Scientific Research of Young Doctors of Anesthesia and Pain (MT23-1)
Citations: not cited yet (Europe PMC); 48 references in the paper

Abstract

Perioperative neurocognitive disorders (PND) are a prevalent and disabling complication in elderly patients after anesthesia and surgery, imposing a growing clinical burden in aging societies. Despite its high incidence, effective therapies for PND remain unavailable. Surgery‐induced neuroinflammation, characterized by excessive oxidative stress, microglial activation, and blood‐brain barrier (BBB) disruption, plays a central role in the development of PND. Here, we develop a PCN biomimetic nanozyme platform based on homologous, highly adhesive neutrophil membrane‐encapsulated Pd/hCeO2 nanoparticles for the treatment of age‐related PND. Benefiting from the innate inflammation‐targeting properties of neutrophil membranes, PCN efficiently traverses the compromised BBB and precisely accumulates in neuroinflammatory regions. PCN exhibits potent reactive oxygen species scavenging activity and markedly attenuates neuroinflammation in the aging brain, while preserving BBB integrity. Specifically, PCN suppresses the pro‐inflammatory and dysmetabolic state of microglia through inhibition of the glycolytic pathway and promotion of aerobic respiration, thereby protecting synaptic function and improving cognitive performance in aged PND mice. In general, this study identifies a biomimetic nanozyme strategy as a promising therapeutic approach for mitigating postoperative cognitive decline or other inflammatory damage in the aging brain.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

Data Availability Statement

Figure 1 and ToC were created in BioRender. Huang, L. (2026) https://BioRender.com/u8g59kf; Figure 3A was created in BioRender. Huang, L. (2026) https://BioRender.com/1147dq7. The RNA‐sequencing data generated in this study have been deposited in the NCBI Gene Expression Omnibus (GEO) database under accession number GSE339068 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339068). Other data supporting the findings of this study are available from the corresponding author upon reasonable request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 3 October 2026: the first record

Recorded: type, language, journal, pages, dates, 18 authors, 5 keywords, 7 funders, 47 references.

Cite

This paper

Huang, L., Cheng, J., Xu, H., Zhang, Q., Zhang, X., Liu, Y., Zhang, Y., Dai, W., Xiong, Z., Guo, L., Xu, L., Wang, W., Xu, X., Zhou, Y., Yu, W., Li, B., Su, D., & Wen, D. (2026). A Neutrophil Membrane-Encapsulated Pd/hCeO<sub>2</sub> Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive Disorders. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e78033. https://doi.org/10.1002/advs.78033

BibTeX

@article{huang2026neutrophil,
author = {Huang, Lili and Cheng, Jiahui and Xu, Huan and Zhang, Qiang and Zhang, Xiao and Liu, Ye and Zhang, Yizhe and Dai, Wanbing and Xiong, Zhi and Guo, Linghuan and Xu, Lingling and Wang, Wen and Xu, Xin and Zhou, Yan and Yu, Weifeng and Li, Bo and Su, Diansan and Wen, Daxiang},
title = {{A Neutrophil Membrane-Encapsulated Pd/hCeO\<sub\>2\</sub\> Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive Disorders}},
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = sep,
pages = {e78033},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/advs.78033},
url = {https://doi.org/10.1002/advs.78033},
pmid = {42816949},
pmcid = {PMC13627777}
}

RIS

TY - JOUR
AU - Huang, Lili
AU - Cheng, Jiahui
AU - Xu, Huan
AU - Zhang, Qiang
AU - Zhang, Xiao
AU - Liu, Ye
AU - Zhang, Yizhe
AU - Dai, Wanbing
AU - Xiong, Zhi
AU - Guo, Linghuan
AU - Xu, Lingling
AU - Wang, Wen
AU - Xu, Xin
AU - Zhou, Yan
AU - Yu, Weifeng
AU - Li, Bo
AU - Su, Diansan
AU - Wen, Daxiang
TI - A Neutrophil Membrane-Encapsulated Pd/hCeO<sub>2</sub> Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive Disorders
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/09/30
SP - e78033
SN - 2198-3844
PB - Wiley
DO - 10.1002/advs.78033
UR - https://doi.org/10.1002/advs.78033
LA - en
ER -

CSL-JSON

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