Effect of Transcranial Direct Current Stimulation Targeting Brain Regions Identified Through Voxel-Based Morphometry on One-Legged Standing Balance With Eyes Closed.
Overview
- Graduate School Niigata University of Health and Welfare Niigata‐shi Niigata Japan
- Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare Niigata‐shi Niigata Japan
- Department of Physical Therapy Niigata University of Health and Welfare Niigata‐shi Niigata Japan
- Department of Radiological Sciences Gunma Paz University Takasaki Gunma Japan
- Department of Radiological Technology Niigata University of Health and Welfare Niigata‐shi Niigata Japan
Abstract
Introduction: Voxel‐based morphometry (VBM) is a neuroimaging technique for quantitative analysis of brain structure. Previous studies have reported an association between gray matter (GM) volume in specific brain regions and balance function. Anodal transcranial direct current stimulation (tDCS) enhances excitability beneath the stimulation site and facilitates motor function. However, it remains unclear which brain regions are associated with one‐legged standing (OLS) balance with eyes closed and whether anodal tDCS targeting these regions enhances this balance function. The present study aimed to (i) identify brain regions associated with OLS balance with eyes closed using VBM and (ii) test whether anodal tDCS applied to the identified region enhances this balance function.
Methods: The study consisted of two experiments. In Experiment 1, magnetic resonance imaging scans were performed in 66 healthy participants who underwent measurement of OLS balance time with eyes closed. In Experiment 2, brain regions identified through VBM analysis were stimulated with anodal tDCS, and the effect on OLS balance with eyes closed was evaluated. Thirty‐two healthy participants were randomly assigned to the tDCS or sham group, and OLS duration with eyes closed was assessed before and after stimulation.
Results: In Experiment 1, whole‐brain analysis revealed that the cerebellar posterior vermis was associated with OLS balance with eyes closed. In Experiment 2, OLS duration with eyes closed was significantly increased poststimulation in the tDCS group after targeting the cerebellar vermis, including posterior vermis, while no significant difference was found between pre‐ and poststimulation in the sham group.
Conclusion: GM volume of the cerebellar posterior vermis is associated with OLS balance with eyes closed. Anodal tDCS targeting the cerebellar vermis, including the posterior vermis, enhances this balance function.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
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Data Availability Statement
Data and code used in this study will be made available upon reasonable request to the corresponding author.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 4 keywords, 11 MeSH terms, 1 funder, 74 references.
Cite
This paper
Takahashi, H., Inukai, Y., Nagasaka, K., Miyaguchi, S., Sakurai, N., Kodama, N., Otsuru, N., & Onishi, H. (2026). Effect of Transcranial Direct Current Stimulation Targeting Brain Regions Identified Through Voxel-Based Morphometry on One-Legged Standing Balance With Eyes Closed. Brain and behavior, 16(4), e71425. https://
BibTeX
@article{takahashi2026ef
author = {Takahashi, Hirona and Inukai, Yasuto and Nagasaka, Kazuaki and Miyaguchi, Shota and Sakurai, Noriko and Kodama, Naoki and Otsuru, Naofumi and Onishi, Hideaki},
title = {{Effect of Transcranial Direct Current Stimulation Targeting Brain Regions Identified Through Voxel-Based Morphometry on One-Legged Standing Balance With Eyes Closed}},
journal = {Brain and behavior},
year = {2026},
month = apr,
volume = {16},
number = {4},
pages = {e71425},
publisher = {Wiley},
issn = {2162-3279},
doi = {10.1002/
url = {https://
pmid = {42021495},
pmcid = {PMC13103282}
}
RIS
TY - JOUR
AU - Takahashi, Hirona
AU - Inukai, Yasuto
AU - Nagasaka, Kazuaki
AU - Miyaguchi, Shota
AU - Sakurai, Noriko
AU - Kodama, Naoki
AU - Otsuru, Naofumi
AU - Onishi, Hideaki
TI - Effect of Transcranial Direct Current Stimulation Targeting Brain Regions Identified Through Voxel-Based Morphometry on One-Legged Standing Balance With Eyes Closed
T2 - Brain and behavior
J2 - Brain Behav
PY - 2026
DA - 2026/
VL - 16
IS - 4
SP - e71425
SN - 2162-3279
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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"container-title": "Brain and behavior",
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"family": "Takahashi",
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"given": "Naofumi"
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"family": "Onishi",
"given": "Hideaki"
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"ISSN": "2162-3279",
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"URL": "https://
"language": "en",
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