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Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks.

Overview

Authors: Yanping Weng1, Yu Ma2,3, Wanwan Hou1, Haibo Li4, Yuanfeng Zhou5, Rui Zhao6,7, Hao Li7, Lian Chen8, Yangyang Ma8, Li Jin1,9, Yi Wang2,3, Yu An1,10
  1. Human Phenome Institute, Zhangjiang Fudan International Innovation Center, MOE Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai, China
  2. Department of Neurology, Children's Hospital of Fudan University, Shanghai, China
  3. Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, China
  4. Ningbo Key Laboratory of Genomic Medicine and Birth Defects Prevention, The Affiliated Women and Children's Hospital of Ningbo University, Ningbo, China
  5. Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China
  6. Department of Neurosurgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  7. Department of Neurosurgery, Children's Hospital of Fudan University, Shanghai, China
  8. Department of Pathology, Children's Hospital of Fudan University, Shanghai, China
  9. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
  10. Institute of Medical Genetics and Genomics, Fudan University, Shanghai, China
Journal: Epilepsia, volume 67, issue 6, pages 3211-3225
Dates: received 19 September 2025; accepted 9 February 2026; published online 13 March 2026; in print June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/epi.70161 · PMID 41823335 · PMCID PMC13285232 · OpenAlex W7135242446
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), epilepsy (population), cellular / molecular (subfield)
Methods: Statistics, Machine learning
Keywords: classification model, epilepsy subtypes, gene network, machine learning, transcriptome sequencing
MeSH: Drug Resistant Epilepsy*, Gene Regulatory Networks*, Machine Learning*, Transcriptome*, Classification Algorithms, Clustering Algorithms, Female, Humans, Male (* major topic)
Topic: Epilepsy research and treatment (Psychiatry and Mental health, Medicine), according to OpenAlex
Funding: National Key Research and Development Program of China (2024YFC3406700, 2024YFC3406701); Municipal Science and TechnologyMajor Project (2017SHZDZX01); Ningbo Science and Technology project (2023Z178)
Citations: not cited yet (Europe PMC); 46 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1002/epi.70161.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 5 keywords, 9 MeSH terms, 3 funders, 45 references.

Cite

This paper

Weng, Y., Ma, Y., Hou, W., Li, H., Zhou, Y., Zhao, R., Li, H., Chen, L., Ma, Y., Jin, L., Wang, Y., & An, Y. (2026). Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks. Epilepsia, 67(6), 3211-3225. https://doi.org/10.1002/epi.70161

BibTeX

@article{weng2026decoding,
author = {Weng, Yanping and Ma, Yu and Hou, Wanwan and Li, Haibo and Zhou, Yuanfeng and Zhao, Rui and Li, Hao and Chen, Lian and Ma, Yangyang and Jin, Li and Wang, Yi and An, Yu},
title = {{Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks}},
journal = {Epilepsia},
year = {2026},
month = mar,
volume = {67},
number = {6},
pages = {3211--3225},
publisher = {Wiley},
issn = {0013-9580},
doi = {10.1002/epi.70161},
url = {https://doi.org/10.1002/epi.70161},
pmid = {41823335},
pmcid = {PMC13285232}
}

RIS

TY - JOUR
AU - Weng, Yanping
AU - Ma, Yu
AU - Hou, Wanwan
AU - Li, Haibo
AU - Zhou, Yuanfeng
AU - Zhao, Rui
AU - Li, Hao
AU - Chen, Lian
AU - Ma, Yangyang
AU - Jin, Li
AU - Wang, Yi
AU - An, Yu
TI - Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks
T2 - Epilepsia
J2 - Epilepsia
PY - 2026
DA - 2026/03/13
VL - 67
IS - 6
SP - 3211
EP - 3225
SN - 0013-9580
PB - Wiley
DO - 10.1002/epi.70161
UR - https://doi.org/10.1002/epi.70161
LA - en
ER -

CSL-JSON

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