Alterations in resting-state functional connectivity relate to psychopathology trajectories during emerging adolescence.
The 7 matches · 2 of them tie a paragraph to a whole file, not to given lines: weak matches, whose lines are not tinted
- [1] § METHODS AND MATERIALS › Statistical analyses › Longitudinal multilevel modeling ↔ rsfc_p_JCPPA_analyses.R, lines 1–50 · score 0.75 · sensorimotor mouth, sensorimotor hand, cingulo parietal, auditory, retrosplenial, ABCD
- [2] § RESULTS › Within‐ and between‐network RSFC relations with p‐factor trajectories ↔ rsfc_p_JCPPA_analyses.R, lines 1–50 · score 0.72 · cingulo opercular, ventral attention, dorsal attention, DMN VAN, frontoparietal, salience
- [3] § METHODS AND MATERIALS › Resting‐state functional connectivity (RSFC) ↔ rsfc_p_JCPPA_df.R, the whole file · a weak match · score 0.57 · resting state scans, transformed, FD, frames, motion, RSFC
- [4] § RESULTS › Within‐ and between‐network RSFC relations with p‐factor trajectories ↔ rsfc_p_JCPPA_analyses.R, lines 1282–1339 · score 0.57 · FDR correction, VAN CON, DMN CON, DMN DAN, Exploratory, factor scores
- [5] § RESULTS › Unconditional linear and non‐linear growth models ↔ rsfc_p_JCPPA_analyses.R, lines 405–449 · score 0.56 · growth models, quadratic model, unconditional, fit, linear, trajectory
- [6] § RESULTS › Within‐ and between‐network RSFC relations with p‐factor trajectories ↔ rsfc_p_JCPPA_analyses.R, lines 52–100 · score 0.55 · ventral attention network, dorsal attention network, salience network, cingulo, FPN, Connectivity
- [7] § METHODS AND MATERIALS › Statistical analyses › Longitudinal multilevel modeling ↔ rsfc_p_JCPPA_df.R, the whole file · a weak match · score 0.54 · scanner dummies, MRI, FD, factor scores, intercept, baseline
Paper
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The authors' code
R · 1,815 lines · 92 KB · no license · 5 matches
rsfc_p_JCPPA_analyses.R at commit 882ad37, no license · at the source
Overview
- Department of Psychology Virginia Polytechnic Institute and State University Blacksburg Virginia USA
Abstract
Background: A general psychopathology “p‐factor” captures shared variation across psychiatric disorder categories and is associated with dysfunctions in cognitive control. Alterations in resting‐state functional connectivity (RSFC) of cognitive and attentional networks have been associated concurrently with the p‐factor in youth samples. However, we do not yet know whether these RSFC alterations prospectively relate to change in the p‐factor over time during the transition to adolescence, when many forms of disorder onset or worsen.
Methods: We examined whether baseline RSFC was prospectively related to the trajectory of p‐factor scores over three years in 9344 preadolescents (age 9–10 at baseline) from the Adolescent Brain Cognitive Development Adolescent Brain Cognitive DevelopmentSM (ABCD) study. Using longitudinal multilevel modeling, we tested whether baseline within‐ and between‐network RSFC of the default mode (DMN), frontoparietal (FPN), salience (SN), cingulo‐opercular (CON), and ventral and dorsal attention (VAN and DAN) networks were related to the intercept (between‐person differences) and slope (within‐person rate of change) of p‐factor scores over four ABCD study waves (3‐year timeframe).
Results: There was a significant nonlinear, quadratic trajectory of p‐factor scores over wave. Lower within‐DMN and within‐DAN connectivity and greater DMN‐DAN, DMN‐CON, and VAN‐CON connectivity were associated with higher between‐person levels of p‐factor scores, which persisted over time. Greater VAN‐DAN and SN‐CON connectivity and lower DMN‐VAN connectivity were prospectively associated with steeper within‐person rates of quadratic change in p‐factor scores over time.
Conclusion: These novel results identify specific alterations in RSFC within and between core networks involved in self‐referential processing, bottom‐up and town‐down attention, salience, and cognitive control that might contribute to general psychopathology development in early adolescence. Children with aberrant connectivity between the DMN and VAN, SN and CON, and VAN and DAN networks may be vulnerable to increases in general psychopathology during the transition to adolescence.
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Ageyr13/ABCD_RSFC_MLM
882ad37565b38cda2bcfa92c365ed62a9890adc6, 10 September 2025Availability: 1 check, the latest on 28 September 2026: the link answers
- 28 September 2026: the link answers
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- rsfc_p_JCPPA_df.R — R, 70 lines, 2 matches, shown from its source
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Data availability statement
The data that support the findings of this study are openly available in NIMH Data Archive at http://
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Recorded: type, language, journal, pages, dates, 4 authors, 6 keywords, 2 funders, 68 references.
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This paper
Devine, J. J., Hosterman, G. R., Sloss, J., & Romer, A. L. (2026). Alterations in resting-state functional connectivity relate to psychopathology trajectories during emerging adolescence. JCPP advances, e70135. https://
BibTeX
@article{devine2026alter
author = {Devine, Jenna Jones and Hosterman, Garrett R. and Sloss, Jolee and Romer, Adrienne L.},
title = {{Alterations in resting-state functional connectivity relate to psychopathology trajectories during emerging adolescence}},
journal = {JCPP advances},
year = {2026},
month = may,
pages = {e70135},
publisher = {Wiley},
issn = {2692-9384},
doi = {10.1002/
url = {https://
pmid = {42416655},
pmcid = {PMC13339399}
}
RIS
TY - JOUR
AU - Devine, Jenna Jones
AU - Hosterman, Garrett R.
AU - Sloss, Jolee
AU - Romer, Adrienne L.
TI - Alterations in resting-state functional connectivity relate to psychopathology trajectories during emerging adolescence
T2 - JCPP advances
J2 - JCPP Adv
PY - 2026
DA - 2026/
SP - e70135
SN - 2692-9384
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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