No Additional Benefit of 185 Hz Versus 130 Hz at Equivalent Energy in Deep Brain Stimulation for Tremor: A Randomized Prospective Clinical Trial.
Overview
- Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany
- Department of Neurology with Experimental Neurology Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin Berlin Germany
- Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM3)—Research Center Jülich Jülich Germany
- Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany
Abstract
Background: Deep brain stimulation (DBS) of the ventral intermediate nucleus and posterior subthalamic area (VIM/
Objective: To compare tremor suppression under total electrical energy delivered (TEED)‐equivalent stimulation at 130 versus 185 Hz in VIM/
Methods: In this prospective, double‐blind study, acute DBS effects were assessed in 18 people with ET (n = 29 hemispheres), and 25 people with PD (n = 30 hemispheres). Tremor‐suppressive effects, evaluated by accelerometry, were compared with TEED‐equivalent stimulation at 130 and 185 Hz using linear mixed‐effects models, explorative pairwise comparisons, and equivalency testing.
Results: Linear mixed‐effects models revealed no significant effect of stimulation frequency on tremor improvement in both cohorts. Pairwise comparisons showed no consistent differences in total tremor improvement with TEED‐equivalent 130 Hz vs 185 Hz DBS. Post‐hoc equivalence testing confirmed equivalence of stimulation frequencies under TEED‐equivalent conditions within a ±20% margin of relative tremor improvement.
Conclusion: This study provides Level II evidence that a higher stimulation frequency of 185 Hz does not offer additional benefit in deep brain stimulation for tremor in VIM/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- zenodo:23412873, at Zenodo; found in “Data Availability Statement”
Data Availability Statement
The main outcome data supporting the findings of this study are available via zenodo (doi:10.5281/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 4 November 2026: the first record
Recorded: type, language, journal, pages, dates, 10 authors, 5 keywords, 1 funder, 41 references.
Cite
This paper
van der Linden, C., Trapp, P., Dembek, T. A., Schedlich‐Teufer, C., Brandt, G. A., Jergas, H., Fink, G. R., Visser‐Vandewalle, V., Barbe, M. T., & Petry‐Schmelzer, J. N. (2026). No Additional Benefit of 185 Hz Versus 130 Hz at Equivalent Energy in Deep Brain Stimulation for Tremor: A Randomized Prospective Clinical Trial. Movement disorders clinical practice, 10.1002/
BibTeX
@article{vanderlinden202
author = {van der Linden, Christina and Trapp, Peer and Dembek, Till A. and Schedlich‐Teufer, Charlotte and Brandt, Gregor A. and Jergas, Hannah and Fink, Gereon R. and Visser‐Vandewalle, Veerle and Barbe, Michael T. and Petry‐Schmelzer, Jan Niklas},
title = {{No Additional Benefit of 185 Hz Versus 130 Hz at Equivalent Energy in Deep Brain Stimulation for Tremor: A Randomized Prospective Clinical Trial}},
journal = {Movement disorders clinical practice},
year = {2026},
month = nov,
pages = {10.1002/
publisher = {Wiley},
issn = {2330-1619},
doi = {10.1002/
url = {https://
pmid = {42972941},
pmcid = {PMC13728422}
}
RIS
TY - JOUR
AU - van der Linden, Christina
AU - Trapp, Peer
AU - Dembek, Till A.
AU - Schedlich‐Teufer, Charlotte
AU - Brandt, Gregor A.
AU - Jergas, Hannah
AU - Fink, Gereon R.
AU - Visser‐Vandewalle, Veerle
AU - Barbe, Michael T.
AU - Petry‐Schmelzer, Jan Niklas
TI - No Additional Benefit of 185 Hz Versus 130 Hz at Equivalent Energy in Deep Brain Stimulation for Tremor: A Randomized Prospective Clinical Trial
T2 - Movement disorders clinical practice
J2 - Mov Disord Clin Pract
PY - 2026
DA - 2026/
SP - 10.1002/
SN - 2330-1619
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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