OSCR

Multi-dimensional plasma proteomic profiling elucidates molecular mechanisms and pathophysiological networks in pediatric severe traumatic brain injury.

Overview

Authors: Enis Cela1, David Tweddell2, Mark Daley2,3, Maria Morello4, Gediminas Cepinskas5,6,7, Douglas D Fraser1,7,8,9,10,11,12
ORCID iDs: Maria Morello, Gediminas Cepinskas
  1. Physiology & Pharmacology, Western University, London, ON N6A 3K7 Canada
  2. Computer Science, Western University, London, ON N6A 3K7 Canada
  3. Epidemiology and Biostatistics, Western University, London, ON N6A 3K7 Canada
  4. Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
  5. Medical Biophysics, Western University, London, ON N6A 3K7 Canada
  6. Anatomy and Cell Biology, Western University, London, ON N6A 3K7 Canada
  7. London Health Sciences Centre Research Institute, London, ON N6C 2R5 Canada
  8. Pediatrics, Western University, London, ON N6A 3K7 Canada
  9. Children’s Health Research Institute, London, ON N6C 4V3 Canada
  10. Clinical Neurological Sciences, Western University, London, ON N6A 3K7 Canada
  11. GSK Chair in Clinical Pharmacology, Western University, London, ON N6A 3K7 Canada
  12. Room A5-132, Victoria Research Laboratories, 800 Commissionaires Road East, London, ON N6A 5W9 Canada
Institutions: Western University (Canada); University of Rome Tor Vergata (Italy); London Health Sciences Centre Research Institute (Canada); Children’s Health Research Institute (Canada)
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.], volume 75, issue 1, article 70
Dates: received 31 October 2025; accepted 14 February 2026; published online 27 March 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s00011-026-02209-6 · PMID 41896418 · PMCID PMC13031234 · OpenAlex W7141251935
Open access: hybrid, a free copy (OpenAlex)
Status: code on request (how the code is found and verified)
Categories: genetics / omics (modality), human (organism), traumatic brain injury (population), cellular / molecular (subfield)
Methods: Statistics, Machine learning, Connectivity, Physiology & signal measures
Keywords: Pediatric, Traumatic brain injury, Proteomics, Pathways, Protein alterations, Inflammation
MeSH: Brain Injuries, Traumatic*, Adolescent, Child, Child, Preschool, Female, Humans, Male, Protein Interaction Maps, Proteomics (* major topic)
Topic: Traumatic Brain Injury and Neurovascular Disturbances (Clinical Neurology, Medicine), according to OpenAlex
Funding: Academic Medical Organization of Southwestern Ontario; Children's Health Foundation
Citations: not cited yet (Europe PMC); 96 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1007/s00011-026-02209-6.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 6 keywords, 9 MeSH terms, 2 funders, 92 references.

Cite

This paper

Cela, E., Tweddell, D., Daley, M., Morello, M., Cepinskas, G., & Fraser, D. D. (2026). Multi-dimensional plasma proteomic profiling elucidates molecular mechanisms and pathophysiological networks in pediatric severe traumatic brain injury. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 75(1), 70. https://doi.org/10.1007/s00011-026-02209-6

BibTeX

@article{cela2026multi,
author = {Cela, Enis and Tweddell, David and Daley, Mark and Morello, Maria and Cepinskas, Gediminas and Fraser, Douglas D},
title = {{Multi-dimensional plasma proteomic profiling elucidates molecular mechanisms and pathophysiological networks in pediatric severe traumatic brain injury}},
journal = {Inflammation research : official journal of the European Histamine Research Society ... [et al.]},
year = {2026},
month = mar,
volume = {75},
number = {1},
pages = {70},
publisher = {Springer Science+Business Media},
issn = {1023-3830},
doi = {10.1007/s00011-026-02209-6},
url = {https://doi.org/10.1007/s00011-026-02209-6},
pmid = {41896418},
pmcid = {PMC13031234}
}

RIS

TY - JOUR
AU - Cela, Enis
AU - Tweddell, David
AU - Daley, Mark
AU - Morello, Maria
AU - Cepinskas, Gediminas
AU - Fraser, Douglas D
TI - Multi-dimensional plasma proteomic profiling elucidates molecular mechanisms and pathophysiological networks in pediatric severe traumatic brain injury
T2 - Inflammation research : official journal of the European Histamine Research Society ... [et al.]
J2 - Inflamm Res
PY - 2026
DA - 2026/03/27
VL - 75
IS - 1
SP - 70
SN - 1023-3830
PB - Springer Science+Business Media
DO - 10.1007/s00011-026-02209-6
UR - https://doi.org/10.1007/s00011-026-02209-6
LA - en
ER -

CSL-JSON

{
"id": "10.1007/s00011-026-02209-6",
"type": "article-journal",
"title": "Multi-dimensional plasma proteomic profiling elucidates molecular mechanisms and pathophysiological networks in pediatric severe traumatic brain injury",
"container-title": "Inflammation research : official journal of the European Histamine Research Society ... [et al.]",
"author": [
{
"family": "Cela",
"given": "Enis"
},
{
"family": "Tweddell",
"given": "David"
},
{
"family": "Daley",
"given": "Mark"
},
{
"family": "Morello",
"given": "Maria"
},
{
"family": "Cepinskas",
"given": "Gediminas"
},
{
"family": "Fraser",
"given": "Douglas D"
}
],
"container-title-short": "Inflamm Res",
"volume": "75",
"issue": "1",
"page": "70",
"DOI": "10.1007/s00011-026-02209-6",
"PMID": "41896418",
"PMCID": "PMC13031234",
"ISSN": "1023-3830",
"publisher": "Springer Science+Business Media",
"URL": "https://doi.org/10.1007/s00011-026-02209-6",
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
27
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1186/s12967-023-04149-9
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function.
Journal: Journal of translational medicine
In common: genetics / omics, 1 reference, author Gediminas Cepinskas
[2] doi:10.1038/s43587-026-01081-7 [code]
Identification of distinct and shared biomarker panels in different manifestations of cerebral small-vessel disease through proteomic profiling.
Journal: Nature aging
In common: genetics / omics, 3 references
[3] doi:10.3389/fneur.2024.1439318 [code]
Trajectories of systemic immune inflammation index and mortality risk in patients with moderate-to-severe traumatic brain injury: a retrospective cohort study.
Journal: Frontiers in neurology
In common: traumatic brain injury, 2 references
[4] doi:10.1093/braincomms/fcaf096 [code]
Influence of apolipoprotein E genotype on the proteomic profile in cerebral microdialysis after human severe traumatic brain injury: a prospective observational study.
Journal: Brain communications
In common: traumatic brain injury, genetics / omics, 2 references
[5] doi:10.1111/cns.70362
Animal Models of Traumatic Brain Injury and Their Relevance in Clinical Settings.
Journal: CNS neuroscience & therapeutics
In common: traumatic brain injury, 2 references
[6] doi:10.1007/s10753-026-02549-9
A Dynamic and Complex Early Inflammatory Response in Blood and Cerebrospinal Fluid of Severe Traumatic Brain Injury Patients: A Dual Platform Analysis.
Journal: Inflammation
In common: traumatic brain injury, 2 references
[7] doi:10.1186/s12883-026-05109-8
A preliminary analysis of the inflammatory protein landscape in the CSF of mid- to late-stage Parkinson's disease: associations with motor severity and subtypes.
Journal: BMC neurology
In common: genetics / omics, cellular / molecular, 2 references
[8] doi:10.1186/s13024-025-00874-5
Proteomic landscape of Alzheimer's disease: emerging technologies, advances and insights (2021 - 2025).
Journal: Molecular neurodegeneration
In common: genetics / omics, 2 references
[9] doi:10.7554/elife.105225 [code]
Modular DNA barcoding of nanobodies enables multiplexed in situ protein imaging and high-throughput biomolecule detection.
Journal: eLife
In common: genetics / omics, 2 references
[10] doi:10.1186/s13195-022-01113-5
Multi-platform proteomic analysis of Alzheimer's disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome.
Journal: Alzheimer's research & therapy
In common: genetics / omics, 2 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: code errors and mismatches between the code and the paper about this paper and its code, from readers and its authors, beside the paper and its tracing map.

Reproductions: reports from readers who ran the authors' code and did not get the paper's result, what they ran, with which environment, commit and data.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.