Mitochondrial ribosomal protein MRPL27 supports glioma malignancy through regulation of oxidative phosphorylation.

Overview

Authors: Jingyao Gu¹, Boya Zhou², Lin Ji³, Haoyang Yuan⁴, Haibo Ji², Mingxiao Zhu⁵, Chunyan He¹, Xueping Gu⁶, Suji Yan⁷, Yin Wang²

ORCID iDs: Yin Wang

Department of Clinical Laboratory, Kunshan Hospital of Chinese Medicine, Affiliated Hospital of Yangzhou University, Kunshan, China
Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China
Operating-Room of The Second Affiliated Hospital of Soochow University, Suzhou, China
Institute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
Department of Hand and Foot Surgery, The People’s Hospital of SuzhouNew District, Suzhou, China
Interventional Medicine Center, The Second Affiliated Hospital of Soochow University, Suzhou, China
Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China

Institutions: Traditional Chinese Medicine Hospital of Kunshan (China); Yangzhou University (China); Second Affiliated Hospital of Soochow University (China); First Affiliated Hospital of Soochow University (China)

Journal: Cellular and molecular life sciences : CMLS, volume 83, issue 1, article 288

Dates: received 9 January 2026; accepted 14 April 2026; published online 25 May 2026

Type: Research article · Language: English

License: CC BY-NC-ND

Identifiers: DOI 10.1007/s00018-026-06236-8 · PMID 42183867 · PMCID PMC13385551 · OpenAlex W7162307804

Open access: gold, a free copy (OpenAlex)

Status: data only

Categories: human (organism), other condition (population), cellular / molecular (subfield)

Methods: Statistics, Smoothing, state filtering, decompositions, Connectivity

Keywords: Glioma progression, MRPL27, Oxidative phosphorylation, Mitochondrial translation

MeSH: Brain Neoplasms*, Glioma*, Mitochondria*, Mitochondrial Proteins*, Oxidative Phosphorylation*, Ribosomal Proteins*, Animals, Apoptosis, Cell Line, Tumor, Cell Movement, Cell Proliferation, Energy Metabolism, Gene Expression Regulation, Neoplastic, Humans, Oxidative Stress (* major topic)

Topic: Mitochondrial Function and Pathology (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex

Funding: National Natural Science Foundation of China (82403043)

Citations: not cited yet (Europe PMC); 54 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

geo:GSE67835, at NCBI GEO; found in the text, “Single-cell RNA sequencing analysis”

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

it says that the data are available on request

Read it in the paper: doi.org/10.1007/s00018-026-06236-8.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 4 keywords, 15 MeSH terms, 1 funder, 54 references.

Cite

This paper

Gu, J., Zhou, B., Ji, L., Yuan, H., Ji, H., Zhu, M., He, C., Gu, X., Yan, S., & Wang, Y. (2026). Mitochondrial ribosomal protein MRPL27 supports glioma malignancy through regulation of oxidative phosphorylation. Cellular and molecular life sciences : CMLS, 83(1), 288. https://doi.org/10.1007/s00018-026-06236-8

BibTeX

@article{gu2026mitochondrial, author = {Gu, Jingyao and Zhou, Boya and Ji, Lin and Yuan, Haoyang and Ji, Haibo and Zhu, Mingxiao and He, Chunyan and Gu, Xueping and Yan, Suji and Wang, Yin}, title = {{Mitochondrial ribosomal protein MRPL27 supports glioma malignancy through regulation of oxidative phosphorylation}}, journal = {Cellular and molecular life sciences : CMLS}, year = {2026}, month = may, volume = {83}, number = {1}, pages = {288}, publisher = {Springer}, issn = {1420-682X}, doi = {10.1007/s00018-026-06236-8}, url = {https://doi.org/10.1007/s00018-026-06236-8}, pmid = {42183867}, pmcid = {PMC13385551} }

RIS

TY - JOUR AU - Gu, Jingyao AU - Zhou, Boya AU - Ji, Lin AU - Yuan, Haoyang AU - Ji, Haibo AU - Zhu, Mingxiao AU - He, Chunyan AU - Gu, Xueping AU - Yan, Suji AU - Wang, Yin TI - Mitochondrial ribosomal protein MRPL27 supports glioma malignancy through regulation of oxidative phosphorylation T2 - Cellular and molecular life sciences : CMLS J2 - Cell Mol Life Sci PY - 2026 DA - 2026/05/25 VL - 83 IS - 1 SP - 288 SN - 1420-682X PB - Springer DO - 10.1007/s00018-026-06236-8 UR - https://doi.org/10.1007/s00018-026-06236-8 LA - en ER -

CSL-JSON

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