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METTL3-dependent m⁶A maturation of miR-140-3p contributes to hippocampal neuronal apoptosis through the OTX2/Wnt/β-catenin axis under chronic stress.

Overview

Authors: Yuanxiang Zhang1, Xin Du1,2,3, Mengxue Fu1,2, Haitao Hu1,2, Juan Lu1,2, Tongshuai Pan1,2, Lili Yuan4, Yigao Wu4, Jiucui Tong1,5
  1. School of Pharmacy, Wannan Medical University, Wuhu, 241002 China
  2. Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wannan Medical University, Wuhu, 241001 China
  3. Wuhu Vocational College of Medical and Health, Wuhu, 241100 China
  4. Department of Medical Psychology, The First Affiliated Hospital of Wannan Medical University, Wuhu, 241001 China
  5. Department of Pharmacy, The First Affiliated Hospital of Wannan Medical University, Wuhu, 241001 China
Institutions: Wannan Medical College (China); Wuhu Vocational College of Medical and Health (China); First Affiliated Hospital of Wannan Medical College (China)
Journal: Molecular biology reports, volume 53, issue 1, article 1340
Dates: received 1 June 2026; accepted 20 July 2026; published online 4 August 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s11033-026-12462-x · PMID 42550296 · PMCID PMC13437767 · OpenAlex W7172426536
Open access: hybrid, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: human (organism), rat (organism), depression (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: METTL3, N6-methyladenosine, miR-140-3p, OTX2, Wnt/β-catenin signaling pathway, Neuronal apoptosis, Depression
MeSH: Hippocampus*, Methyltransferases*, MicroRNAs*, Otx Transcription Factors*, Stress, Psychological*, Adenosine, Animals, Apoptosis, beta Catenin, Epitranscriptome, Humans, Male, Neurons, Rats, Rats, Sprague-Dawley, RNA Methylation, Wnt Signaling Pathway (* major topic)
Topic: RNA modifications and cancer (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Wannan Medical University Horizontal Research Project (No. H202503); the Major Natural Science Project of Universities in Anhui Province (No. 2024AH040248); the Major Humanities and Social Sciences Project of Universities in Anhui Province (No. 2025AHGXSK20032)
Citations: not cited yet (Europe PMC); 48 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1007/s11033-026-12462-x.

Versions

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Version 3, 28 September 2026

  • Publisher: n/a → Springer Nature

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 7 keywords, 17 MeSH terms, 3 funders, 48 references.

Cite

This paper

Zhang, Y., Du, X., Fu, M., Hu, H., Lu, J., Pan, T., Yuan, L., Wu, Y., & Tong, J. (2026). METTL3-dependent m⁶A maturation of miR-140-3p contributes to hippocampal neuronal apoptosis through the OTX2/Wnt/β-catenin axis under chronic stress. Molecular biology reports, 53(1), 1340. https://doi.org/10.1007/s11033-026-12462-x

BibTeX

@article{zhang2026mettl3,
author = {Zhang, Yuanxiang and Du, Xin and Fu, Mengxue and Hu, Haitao and Lu, Juan and Pan, Tongshuai and Yuan, Lili and Wu, Yigao and Tong, Jiucui},
title = {{METTL3-dependent m⁶A maturation of miR-140-3p contributes to hippocampal neuronal apoptosis through the OTX2/Wnt/β-catenin axis under chronic stress}},
journal = {Molecular biology reports},
year = {2026},
month = aug,
volume = {53},
number = {1},
pages = {1340},
publisher = {Springer Nature},
issn = {0301-4851},
doi = {10.1007/s11033-026-12462-x},
url = {https://doi.org/10.1007/s11033-026-12462-x},
pmid = {42550296},
pmcid = {PMC13437767}
}

RIS

TY - JOUR
AU - Zhang, Yuanxiang
AU - Du, Xin
AU - Fu, Mengxue
AU - Hu, Haitao
AU - Lu, Juan
AU - Pan, Tongshuai
AU - Yuan, Lili
AU - Wu, Yigao
AU - Tong, Jiucui
TI - METTL3-dependent m⁶A maturation of miR-140-3p contributes to hippocampal neuronal apoptosis through the OTX2/Wnt/β-catenin axis under chronic stress
T2 - Molecular biology reports
J2 - Mol Biol Rep
PY - 2026
DA - 2026/08/04
VL - 53
IS - 1
SP - 1340
SN - 0301-4851
PB - Springer Nature
DO - 10.1007/s11033-026-12462-x
UR - https://doi.org/10.1007/s11033-026-12462-x
LA - en
ER -

CSL-JSON

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