OSCR

Single-cell transcriptomic profiling of colorectal cancer brain metastasis.

Overview

Authors: Kehong Wei1,2, Qing Gao1, Chaoliang Xu1, Deshen Pan1, Yurui He3, Yaohua Liu4, Deshui Jia1, Cheng Chang2
  1. Department of Radiation Oncology, Institute of Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620 China
  2. Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030 China
  3. College of Arts and Sciences, Texas A&M University, College Station, TX 77840 USA
  4. Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620 China
Institutions: Shanghai Jiao Tong University (China); Shanghai Chest Hospital (China); Shanghai First People's Hospital (China); Texas A&M University (United States)
Journal: Discover oncology, volume 17, issue 1, article 947
Dates: received 7 February 2026; accepted 30 April 2026; published online 6 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s12672-026-05159-x · PMID 42090027 · PMCID PMC13315048 · OpenAlex W7160432288
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Connectivity
Keywords: Single-cell RNA sequencing, Colorectal cancer, Brain metastasis
Topic: Brain Metastases and Treatment (Pulmonary and Respiratory Medicine, Medicine), according to OpenAlex
Funding: Science and Technology Commission of Shanghai Municipality Experimental Animal Research Fund (24141900500); Natural Science Foundation of Shanghai (24ZR1464100); Nurture projects for basic research of Shanghai Chest Hospital (2021YNJCM09); National Key Research and Development Program of China (2024YFA0917700)
Citations: not cited yet (Europe PMC); 42 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1007/s12672-026-05159-x.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 3 keywords, 4 funders, 42 references.

Cite

This paper

Wei, K., Gao, Q., Xu, C., Pan, D., He, Y., Liu, Y., Jia, D., & Chang, C. (2026). Single-cell transcriptomic profiling of colorectal cancer brain metastasis. Discover oncology, 17(1), 947. https://doi.org/10.1007/s12672-026-05159-x

BibTeX

@article{wei2026single,
author = {Wei, Kehong and Gao, Qing and Xu, Chaoliang and Pan, Deshen and He, Yurui and Liu, Yaohua and Jia, Deshui and Chang, Cheng},
title = {{Single-cell transcriptomic profiling of colorectal cancer brain metastasis}},
journal = {Discover oncology},
year = {2026},
month = may,
volume = {17},
number = {1},
pages = {947},
publisher = {Springer},
issn = {2730-6011},
doi = {10.1007/s12672-026-05159-x},
url = {https://doi.org/10.1007/s12672-026-05159-x},
pmid = {42090027},
pmcid = {PMC13315048}
}

RIS

TY - JOUR
AU - Wei, Kehong
AU - Gao, Qing
AU - Xu, Chaoliang
AU - Pan, Deshen
AU - He, Yurui
AU - Liu, Yaohua
AU - Jia, Deshui
AU - Chang, Cheng
TI - Single-cell transcriptomic profiling of colorectal cancer brain metastasis
T2 - Discover oncology
J2 - Discov Oncol
PY - 2026
DA - 2026/05/06
VL - 17
IS - 1
SP - 947
SN - 2730-6011
PB - Springer
DO - 10.1007/s12672-026-05159-x
UR - https://doi.org/10.1007/s12672-026-05159-x
LA - en
ER -

CSL-JSON

{
"id": "10.1007/s12672-026-05159-x",
"type": "article-journal",
"title": "Single-cell transcriptomic profiling of colorectal cancer brain metastasis",
"container-title": "Discover oncology",
"author": [
{
"family": "Wei",
"given": "Kehong"
},
{
"family": "Gao",
"given": "Qing"
},
{
"family": "Xu",
"given": "Chaoliang"
},
{
"family": "Pan",
"given": "Deshen"
},
{
"family": "He",
"given": "Yurui"
},
{
"family": "Liu",
"given": "Yaohua"
},
{
"family": "Jia",
"given": "Deshui"
},
{
"family": "Chang",
"given": "Cheng"
}
],
"container-title-short": "Discov Oncol",
"volume": "17",
"issue": "1",
"page": "947",
"DOI": "10.1007/s12672-026-05159-x",
"PMID": "42090027",
"PMCID": "PMC13315048",
"ISSN": "2730-6011",
"publisher": "Springer",
"URL": "https://doi.org/10.1007/s12672-026-05159-x",
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
6
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.3389/fcell.2026.1738641
Integrative single-cell and bulk RNA sequencing unravels the role of ACTN1 in promoting lung cancer with brain metastasis and epidermal growth factor receptor-tyrosine kinase inhibitor resistance.
Journal: Frontiers in cell and developmental biology
In common: genetics / omics, other condition, cellular / molecular, 2 references
[2] doi:10.1016/j.isci.2026.117510
Single-cell transcriptomic atlas of the human fetal uveal tract reveals heterogeneity in melanocyte populations.
Journal: iScience
In common: genetics / omics, 2 references
[3] doi:10.1016/j.isci.2026.116517 [code]
Spatially resolved transcriptomics in human brain metastases identifies macrophage-tumor interactions associated with survival.
Journal: iScience
In common: genetics / omics, other condition, 2 references
[4] doi:10.1186/s11658-026-00957-1
Lactate-activated astrocytes promote NSCLC brain metastasis through extracellular vesicle-mediated miR-8085/TRIM67/ELK1 signaling axis.
Journal: Cellular & molecular biology letters
In common: other condition, cellular / molecular, 2 references
[5] doi:10.1371/journal.pone.0355902 [code]
Pericyte-derived cancer-associated fibroblasts correlate with poor survival and are enriched after chemoradiotherapy in glioblastoma.
Journal: PloS one
In common: genetics / omics, other condition, cellular / molecular, 1 reference
[6] doi:10.1097/md.0000000000050109
The gut-immune-brain axis in CNS tumors: Causal roles of microbiota and inflammatory proteins unveiled by Mendelian randomization and single-cell transcriptomics.
Journal: Medicine
In common: genetics / omics, other condition, cellular / molecular, 1 reference
[7] doi:10.1186/s12967-026-08447-w
Single-cell and spatial transcriptomes reveal oligodendrocyte remodeling fatty acid metabolism microenvironment of lung cancer brain metastases.
Journal: Journal of translational medicine
In common: genetics / omics, other condition, cellular / molecular, 1 reference
[8] doi:10.1080/19336896.2026.2710965
Epigenetic changes associated with the progression of prion disease in Syrian hamsters (<i>Mesocricetus auratus</i>).
Journal: Prion
In common: genetics / omics, other condition, cellular / molecular, 1 reference
[9] doi:10.1038/s41467-026-76587-0 [code]
Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT.
Journal: Nature communications
In common: genetics / omics, other condition, cellular / molecular, 1 reference
[10] doi:10.1038/s41419-026-08807-w [code]
Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis.
Journal: Cell death & disease
In common: genetics / omics, other condition, cellular / molecular, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.