OSCR

Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor.

Overview

Authors: Isaac W Babcock1, Sydney A Labuzan1, Abigail G Kelly1, Anne E Schuster1, Seblework Alemu1, Lydia A Sibley1, Anne E Marchildon1, Tajie H Harris1,2
ORCID iDs: Tajie H Harris
  1. Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
  2. Lead contact
Institutions: University of Virginia (United States)
Journal: Cell reports, volume 45, issue 6, article 117411
Dates: published online 30 May 2026; in print 23 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.celrep.2026.117411 · PMID 42217186 · PMCID PMC13359089 · OpenAlex W7162795117
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Statistics
Keywords: Genetics, Microglia, Neuroimmunology, Tissue-resident Macrophages, Cp: Neuroscience, Cp: Immunology
MeSH: Gene Targeting*, Microglia*, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor*, Animals, Brain, CX3C Chemokine Receptor 1, Integrases, Macrophages, Mice, Mice, Inbred C57BL, Organic Chemicals, Tamoxifen (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: NINDS NIH HHS (R01 NS134747, R01 NS112516, T32 NS115657); National Institute of Neurological Disorders and Stroke (R01NS134747, 5T32NS1156573, R01NS112516); National Institute of Allergy and Infectious Diseases (T32AI007496, 5T32AI007046); NIAID NIH HHS (T32 AI007046, T32 AI007496); National Institutes of Health; University of Virginia School of Medicine; NIGMS NIH HHS (T32 GM136615); University of Virginia; National Institute of General Medical Sciences (5T32GM136615)
Citations: cited by 1 paper (Europe PMC); 60 references in the paper
Research resources: IL-17 PE RRID:AB_10584331, Ly6c PE RRID:AB_10804510, T-bet PE-Cy7 RRID:AB_11042699, CD3 PE-CF594 RRID:AB_11154041, CD44 APC-eFluor 780 RRID:AB_1272244, FoxP3 eFluor 450 RRID:AB_1518812, CD115 APC RRID:AB_2085221, Donkey anti-rabbit AF594 RRID:AB_2340621, NK1.1 BV711 RRID:AB_2563286, CD64 PE/Cy7 RRID:AB_2563904, Ly6g BV711 RRID:AB_2565971, iNOS APC RRID:AB_2573244, Ly6C PE-Cy7 RRID:AB_2573503, CD44 PE-efluor 610 RRID:AB_2574554, Cx3cr1 Pacific Blue RRID:AB_2632858, CD11c eFluor 506 RRID:AB_2637427, CD4 BV650 RRID:AB_2738083, MHCII SB780 RRID:AB_2744917, F4/80 APC/Cy7 RRID:AB_2894638, TNFα PE RRID:AB_466198, IFN-γ APC RRID:AB_469503, CD3 PE-Cy7 RRID:AB_469571, CD45 AF700 RRID:AB_493715, IBA1 RRID:AB_839504, CD11b PerCP-Cyanine5.5 RRID:AB_953558, CBA/J RRID:IMSR_JAX:000656, C57BL/6J RRID:IMSR_JAX:000664, ROSA26 Ai6/Ai6 RRID:IMSR_JAX:007906, Cx3cr1 CreERT2/CreERT2 RRID:IMSR_JAX:020940, Rstudio (2025.05.1) RRID:SCR_000432, R (version 4.4.0) RRID:SCR_001905, Graphpad prism 9 RRID:SCR_002798, ImageJ RRID:SCR_003070, Bioconductor RRID:SCR_006442, FlowJo V10 RRID:SCR_008520

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: — → Cell Press

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 6 keywords, 12 MeSH terms, 9 funders, 60 references, 35 RRIDs.

Cite

This paper

Babcock, I. W., Labuzan, S. A., Kelly, A. G., Schuster, A. E., Alemu, S., Sibley, L. A., Marchildon, A. E., & Harris, T. H. (2026). Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor. Cell reports, 45(6), 117411. https://doi.org/10.1016/j.celrep.2026.117411

BibTeX

@article{babcock2026enhancing,
author = {Babcock, Isaac W and Labuzan, Sydney A and Kelly, Abigail G and Schuster, Anne E and Alemu, Seblework and Sibley, Lydia A and Marchildon, Anne E and Harris, Tajie H},
title = {{Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor}},
journal = {Cell reports},
year = {2026},
month = may,
volume = {45},
number = {6},
pages = {117411},
publisher = {Cell Press},
issn = {2211-1247},
doi = {10.1016/j.celrep.2026.117411},
url = {https://doi.org/10.1016/j.celrep.2026.117411},
pmid = {42217186},
pmcid = {PMC13359089}
}

RIS

TY - JOUR
AU - Babcock, Isaac W
AU - Labuzan, Sydney A
AU - Kelly, Abigail G
AU - Schuster, Anne E
AU - Alemu, Seblework
AU - Sibley, Lydia A
AU - Marchildon, Anne E
AU - Harris, Tajie H
TI - Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor
T2 - Cell reports
J2 - Cell Rep
PY - 2026
DA - 2026/05/30
VL - 45
IS - 6
SP - 117411
SN - 2211-1247
PB - Cell Press
DO - 10.1016/j.celrep.2026.117411
UR - https://doi.org/10.1016/j.celrep.2026.117411
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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