ZBP1 mediated restriction of Toxoplasma gondii in both the early acute and chronic brain stages of infection.
Overview
Abstract
ZBP1 is an innate sensor of nucleic acids in the Z-conformation and regulates immune responses via cell death pathways and nuclear factor κB signaling. Previous work has demonstrated an essential role for ZBP1 in viral restriction; however, the role ZBP1 plays in protection against other pathogens is in early stages of exploration. Toxoplasma gondii is an obligate intracellular parasite that can infect all nucleated cells and establishes a chronic infection of the brain requiring a robust innate and adaptive immune response and multiple cell death pathways for host survival. Importantly, innate sensors of T. gondii infection of the central nervous system are still being defined. Prior work has implicated caspase-1 and caspase-8 in the control of T. gondii in the brain. Because ZBP1 can activate both caspase-1 and caspase-8, we sought to explore the role of ZBP1 during T. gondii infection. During early infection, we found an increase in parasite burden; a decrease in NK1.1+ cell, neutrophil, and monocyte recruitment; and impaired NK1.1+ cell cytokine production in the peritoneum of Zbp1−/
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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Data
Datasets cited
- doi:10.5061/
dryad.4tmpg4frf , at Dryad; found in “Data availability”
Data availability
All relevant data are presented in the manuscript and the Supplementary Information files or source data are provided in a source data file. The raw data associated with this manuscript can be accessed on Dryad: https://
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 3 keywords, 13 MeSH terms, 4 funders, 106 references.
Cite
This paper
Sibley, L. A., Babcock, I. W., Amadi, N. D., Marchildon, A. E., Kelly, A. G., Labuzan, S. A., Lukens, J. R., & Harris, T. H. (2026). ZBP1 mediated restriction of Toxoplasma gondii in both the early acute and chronic brain stages of infection. ImmunoHorizons, 10(4), vlag015. https://
BibTeX
@article{sibley2026zbp1,
author = {Sibley, Lydia Anne and Babcock, Isaac William and Amadi, Naa Dedee and Marchildon, Anne Elise and Kelly, Abigail Grace and Labuzan, Sydney Ann and Lukens, John Robert and Harris, Tajie Heartsong},
title = {{ZBP1 mediated restriction of Toxoplasma gondii in both the early acute and chronic brain stages of infection}},
journal = {ImmunoHorizons},
year = {2026},
month = apr,
volume = {10},
number = {4},
pages = {vlag015},
publisher = {Oxford University Press},
issn = {2573-7732},
doi = {10.1093/
url = {https://
pmid = {41999653},
pmcid = {PMC13091654}
}
RIS
TY - JOUR
AU - Sibley, Lydia Anne
AU - Babcock, Isaac William
AU - Amadi, Naa Dedee
AU - Marchildon, Anne Elise
AU - Kelly, Abigail Grace
AU - Labuzan, Sydney Ann
AU - Lukens, John Robert
AU - Harris, Tajie Heartsong
TI - ZBP1 mediated restriction of Toxoplasma gondii in both the early acute and chronic brain stages of infection
T2 - ImmunoHorizons
J2 - Immunohorizons
PY - 2026
DA - 2026/
VL - 10
IS - 4
SP - vlag015
SN - 2573-7732
PB - Oxford University Press
DO - 10.1093/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1093/
"type": "article-journal",
"title": "ZBP1 mediated restriction of Toxoplasma gondii in both the early acute and chronic brain stages of infection",
"container-title": "ImmunoHorizons",
"author": [
{
"family": "Sibley",
"given": "Lydia Anne"
},
{
"family": "Babcock",
"given": "Isaac William"
},
{
"family": "Amadi",
"given": "Naa Dedee"
},
{
"family": "Marchildon",
"given": "Anne Elise"
},
{
"family": "Kelly",
"given": "Abigail Grace"
},
{
"family": "Labuzan",
"given": "Sydney Ann"
},
{
"family": "Lukens",
"given": "John Robert"
},
{
"family": "Harris",
"given": "Tajie Heartsong"
}
],
"container-title-short":
"volume": "10",
"issue": "4",
"page": "vlag015",
"DOI": "10.1093/
"PMID": "41999653",
"PMCID": "PMC13091654",
"ISSN": "2573-7732",
"publisher": "Oxford University Press",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
1
]
]
}
}
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