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TCF1+CD4+ T cells and microglia co-orchestrate tertiary lymphoid structures to enhance prognosis and immunotherapy in non-small cell lung cancer with brain metastases.

Overview

Authors: Qian Yu1,2, Rongxin Liao1,2, Haoyu Zheng3,4, Lin Li5, Yusheng Huang1, Yihao Tao6, Rui Deng1,2, Hengqiu He1,2, Li Yu7, Jingyao Lin1,2, Shunping Huang1,2, Xiaoyue Zhang1,2, Zaicheng Xu1,2, Zhenzhou Yang1,2, Yuan Peng1,2
  1. Department of Cancer Center, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China
  2. Chongqing Key Laboratory of Immunotherapy, Chongqing, 400010, China
  3. Department of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China
  4. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China
  5. Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400000, China
  6. Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China
  7. Department of Endocrinology, Armed Police Hospital of Chongqing, Chongqing, 400061, China
Journal: EBioMedicine, volume 127, article 106280
Dates: received 7 November 2025; accepted 17 April 2026; published online 4 May 2026; in print May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.ebiom.2026.106280 · PMID 42085932 · PMCID PMC13157008 · OpenAlex W7160210087
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Connectivity, Machine learning
Keywords: Tertiary lymphoid structures, Brain metastases, Non-small cell lung cancer, TCF1+CD4 T cells, Microglia, CXCL12
MeSH: Brain Neoplasms*, Carcinoma, Non-Small-Cell Lung*, CD4-Positive T-Lymphocytes*, Lung Neoplasms*, Microglia*, Tertiary Lymphoid Structures*, Animals, Disease Models, Animal, Female, Humans, Immunotherapy, Lymphocytes, Tumor-Infiltrating, Male, Mice, Middle Aged, Prognosis, Tumor Microenvironment (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Citations: not cited yet (Europe PMC); 61 references in the paper
Research resources: RRID:AB_10949053, with a rat IgG antibody RRID:AB_1107769, RRID:AB_1107771, hereafter referred to as LLC RRID:CVCL_4358

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1016/j.ebiom.2026.106280.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 15 authors, 6 keywords, 17 MeSH terms, 2 funders, 60 references, 4 RRIDs.

Cite

This paper

Yu, Q., Liao, R., Zheng, H., Li, L., Huang, Y., Tao, Y., Deng, R., He, H., Yu, L., Lin, J., Huang, S., Zhang, X., Xu, Z., Yang, Z., & Peng, Y. (2026). TCF1+CD4+ T cells and microglia co-orchestrate tertiary lymphoid structures to enhance prognosis and immunotherapy in non-small cell lung cancer with brain metastases. EBioMedicine, 127, 106280. https://doi.org/10.1016/j.ebiom.2026.106280

BibTeX

@article{yu2026tcf1,
author = {Yu, Qian and Liao, Rongxin and Zheng, Haoyu and Li, Lin and Huang, Yusheng and Tao, Yihao and Deng, Rui and He, Hengqiu and Yu, Li and Lin, Jingyao and Huang, Shunping and Zhang, Xiaoyue and Xu, Zaicheng and Yang, Zhenzhou and Peng, Yuan},
title = {{TCF1+CD4+ T cells and microglia co-orchestrate tertiary lymphoid structures to enhance prognosis and immunotherapy in non-small cell lung cancer with brain metastases}},
journal = {EBioMedicine},
year = {2026},
month = may,
volume = {127},
pages = {106280},
publisher = {Elsevier},
issn = {2352-3964},
doi = {10.1016/j.ebiom.2026.106280},
url = {https://doi.org/10.1016/j.ebiom.2026.106280},
pmid = {42085932},
pmcid = {PMC13157008}
}

RIS

TY - JOUR
AU - Yu, Qian
AU - Liao, Rongxin
AU - Zheng, Haoyu
AU - Li, Lin
AU - Huang, Yusheng
AU - Tao, Yihao
AU - Deng, Rui
AU - He, Hengqiu
AU - Yu, Li
AU - Lin, Jingyao
AU - Huang, Shunping
AU - Zhang, Xiaoyue
AU - Xu, Zaicheng
AU - Yang, Zhenzhou
AU - Peng, Yuan
TI - TCF1+CD4+ T cells and microglia co-orchestrate tertiary lymphoid structures to enhance prognosis and immunotherapy in non-small cell lung cancer with brain metastases
T2 - EBioMedicine
J2 - EBioMedicine
PY - 2026
DA - 2026/05/04
VL - 127
SP - 106280
SN - 2352-3964
PB - Elsevier
DO - 10.1016/j.ebiom.2026.106280
UR - https://doi.org/10.1016/j.ebiom.2026.106280
LA - en
ER -

CSL-JSON

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