Metabolic assessment of iPSC-derived neurons under ketone-enriched condition: Ketone sensor development and BHB-driven metabolic adaptation.

Overview

Authors: Rohollah Nasiri^1,2, Farzaneh Fayazbakhsh¹, Reyhaneh Sanei¹, Tingting Wu², Nayere Taebnia^3,4, Rouhollah Habibey⁵, Omid Fotouhi⁶, John Cognetti¹, Volker M Lauschke^3,4,7,8, Aman Russom^1,2, Anna Herland^1,2

ORCID iDs: Rohollah Nasiri, Volker M Lauschke

Division of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden
AIMES, Center for the Advancement of Integrated Medical and Engineering Sciences, Department of Neuroscience, Karolinska Institute, Solna, Sweden
Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
Center for Molecular Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
Department of Ophthalmology, Medical Faculty, University of Bonn, Bonn, Germany
Science for Life Laboratory, Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Genome Biology, 17165 Stockholm, Sweden
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology (IKP), Stuttgart, Germany
University of Tübingen, Tübingen, Germany

Institutions: Science for Life Laboratory (Sweden); Karolinska Institutet (Sweden); KTH Royal Institute of Technology (Sweden); University of Bonn (Germany); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (Germany); University of Tübingen (Germany)

Journal: iScience, volume 29, issue 5, article 115702

Dates: received 21 January 2025; accepted 8 April 2026; published online 13 April 2026

Type: Research article · Language: English

License: CC BY-NC-ND

Identifiers: DOI 10.1016/j.isci.2026.115702 · PMID 42088362 · PMCID PMC13138072 · OpenAlex W7154292732

Open access: gold, a free copy (OpenAlex)

Status: code on request

Categories: human (organism), cellular / molecular (subfield)

Methods: Statistics, fMRI & imaging, Single-unit activity, calcium imaging

Keywords: Analytical chemistry, Bioengineering, Cell biology

Topic: Diet and metabolism studies (Physiology, Medicine), according to OpenAlex

Funding: Vetenskapsrådet (2024-03401, 2021-02801, 2022-04060, 2022-01362, 2023-03015); Novo Nordisk (NNF23OC0085944); Robert Bosch Stiftung; European Research Council (101170408); Knut och Alice Wallenbergs Stiftelse (2015- 0178, 2020.0206)

Citations: not cited yet (Europe PMC); 37 references in the paper

Research resources: Goat Anti Mouse IgG Alexa Fluor 488 RRID:AB_2534069, MAP2 Mouse Monoclonal Antibody RRID:AB_477171

Abstract

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Read it in the paper: doi.org/10.1016/j.isci.2026.115702.

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 3 keywords, 5 funders, 36 references, 2 RRIDs.

Cite

This paper

Nasiri, R., Fayazbakhsh, F., Sanei, R., Wu, T., Taebnia, N., Habibey, R., Fotouhi, O., Cognetti, J., Lauschke, V. M., Russom, A., & Herland, A. (2026). Metabolic assessment of iPSC-derived neurons under ketone-enriched condition: Ketone sensor development and BHB-driven metabolic adaptation. iScience, 29(5), 115702. https://doi.org/10.1016/j.isci.2026.115702

BibTeX

@article{nasiri2026metabolic, author = {Nasiri, Rohollah and Fayazbakhsh, Farzaneh and Sanei, Reyhaneh and Wu, Tingting and Taebnia, Nayere and Habibey, Rouhollah and Fotouhi, Omid and Cognetti, John and Lauschke, Volker M and Russom, Aman and Herland, Anna}, title = {{Metabolic assessment of iPSC-derived neurons under ketone-enriched condition: Ketone sensor development and BHB-driven metabolic adaptation}}, journal = {iScience}, year = {2026}, month = apr, volume = {29}, number = {5}, pages = {115702}, publisher = {Elsevier}, issn = {2589-0042}, doi = {10.1016/j.isci.2026.115702}, url = {https://doi.org/10.1016/j.isci.2026.115702}, pmid = {42088362}, pmcid = {PMC13138072} }

RIS

TY - JOUR AU - Nasiri, Rohollah AU - Fayazbakhsh, Farzaneh AU - Sanei, Reyhaneh AU - Wu, Tingting AU - Taebnia, Nayere AU - Habibey, Rouhollah AU - Fotouhi, Omid AU - Cognetti, John AU - Lauschke, Volker M AU - Russom, Aman AU - Herland, Anna TI - Metabolic assessment of iPSC-derived neurons under ketone-enriched condition: Ketone sensor development and BHB-driven metabolic adaptation T2 - iScience J2 - iScience PY - 2026 DA - 2026/04/13 VL - 29 IS - 5 SP - 115702 SN - 2589-0042 PB - Elsevier DO - 10.1016/j.isci.2026.115702 UR - https://doi.org/10.1016/j.isci.2026.115702 LA - en ER -

CSL-JSON

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