A reversible rat model of hyposmia affects respiration-linked brain oscillations and behavior.
Overview
Abstract
Rhythmic breathing coordinates neural activity across olfactory and limbic circuits by coupling nasal airflow to oscillations in the olfactory bulb (OB) and downstream networks. To test how reduced peripheral olfactory input reshapes this respiration-linked coordination, we developed a reversible hyposmia model in rats using intranasal gadolinium chloride. This manipulation impaired hidden cookie performance for around 1 week and was accompanied by nasal epithelial damage. Hyposmia robustly decreased OB respiration-linked (1–10 Hz) and gamma (30–90 Hz) power, with smaller reductions in prefrontal cortex and ventral striatum. In the OB, oscillatory changes were confined to wakefulness, while slow-wave sleep activity was largely preserved, consistent with intact top-down drive during sleep. Additionally, hyposmia increased anxiety-like behavior and produced minor changes in recognition memory without altering locomotion or hedonic drive. Together, these findings connect peripheral nasal function to state-dependent brain synchrony and affect-related behavior.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 4 keywords, 2 funders, 95 references, 1 RRID.
Cite
This paper
Podolecka, W., Bramorska, A., & Hunt, M. J. (2026). A reversible rat model of hyposmia affects respiration-linked brain oscillations and behavior. iScience, 29(5), 115760. https://
BibTeX
@article{podolecka2026re
author = {Podolecka, Wiktoria and Bramorska, Aleksandra and Hunt, Mark Jeremy},
title = {{A reversible rat model of hyposmia affects respiration-linked brain oscillations and behavior}},
journal = {iScience},
year = {2026},
month = apr,
volume = {29},
number = {5},
pages = {115760},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/
url = {https://
pmid = {42111189},
pmcid = {PMC13157005}
}
RIS
TY - JOUR
AU - Podolecka, Wiktoria
AU - Bramorska, Aleksandra
AU - Hunt, Mark Jeremy
TI - A reversible rat model of hyposmia affects respiration-linked brain oscillations and behavior
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/
VL - 29
IS - 5
SP - 115760
SN - 2589-0042
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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"URL": "https://
"language": "en",
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