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A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice.

Code ↔ Paper

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Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

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The authors' code

MATLAB · 18 lines · 718 B · CC-BY-4.0

  1. function [power_log, freq, time] = analysis_lfp(data, bin, window, noverlap, nfft, fs, pre)
  2. % data: K x Nsamp（每行一个trial）
  3. % 输出 power_log: (power - baseline_mean) ./ baseline_mean，逐 trial 做基线
  4. % 基线定义：time-pre <= 0（把 spectrogram 的时间轴左移 pre 秒）
  6. % ---- 计算每个 trial 的时频功率 ----
  7. K = size(data,1);
  8. [~, freq, time, P0] = spectrogram(data(1,:), window, noverlap, nfft, fs);
  9. F = numel(freq); T = numel(time);
  10. power = nan(F, T, K);
  11. power(:,:,1) = P0;
  12. for k = 2:K
  13. [~, ~, ~, power(:,:,k)] = spectrogram(data(k,:), window, noverlap, nfft, fs);
  14. end
  15. % power: F x T x K
  16. power_log = 10*log10(power)
  18. end

analysis_lfp.m, under CC-BY-4.0 · at the source

Overview

Authors: Xinsong Guo1, Mengyan Liu1, Qingcheng Xiong1, Howai Ngai1, Mingdong He1, Xinying Li1,2, Yingwei Zheng3, Fuqiang Xu4, Minghong Ma5, Ruiqi Wu1,2
ORCID iDs: Xinsong Guo, Mengyan Liu, Qingcheng Xiong, Mingdong He, Xinying Li, Minghong Ma, Ruiqi Wu
  1. Shanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Brain Function and Disorders, Ministry of Education Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China
  2. State Key Laboratory of Digital Medical Engineering, Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya 572025, China
  3. Jiangsu Key Laboratory of Brain Disease and Bioinformation, School of Basic Medicine Sciences, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China
  4. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China
  5. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
Institutions: Fudan University (China); Pudong Medical Center (China); Frontiers Center for Brain Science of the Ministry of Education (China); State Key Laboratory of Digital Medical Engineering (China); Xuzhou Medical College (China); Chinese Academy of Sciences (China); University of Pennsylvania (United States)
Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 34, article e2603853123
Dates: received 14 February 2026; accepted 9 July 2026; published online 18 August 2026; in print 25 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2603853123 · PMID 42611993 · PMCID PMC13506056 · OpenAlex W7172115842
Open access: hybrid, a free copy (OpenAlex)
Status: code verified
Categories: mouse (organism), other condition (population), systems (subfield)
Methods: Spectral & time-frequency, Single-unit activity, calcium imaging
Keywords: slow nasal breathing, perirhinal cortex, high-gamma activity, mechanosensitivity, olfactory sensory neuron
MeSH: Anxiety*, Brain*, Nose*, Animals, Interneurons, Male, Mice, Mice, Inbred C57BL, Nasal Cavity, Olfactory Bulb, Optogenetics (* major topic)
Journal subjects: Biological Sciences, Neuroscience
Topic: Olfactory and Sensory Function Studies (Sensory Systems, Neuroscience), according to OpenAlex
Funding: Shanghai Municipal Health Commission (2024ZZ2039); National Natural Science Foundation of China (31871085); Natural Science Foundation of Shanghai Municipality (21ZR1407300)
Citations: cited by 1 paper (Europe PMC); 67 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repository

Its files are read in the Code ↔ Paper reader above.

figshare 33136013

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 3 files
Software Heritage: not checked
Found in: “Data, Materials, and Software Availability”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: Signal Processing Toolbox (1 file)
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
20 files
At the source: doi.org/10.6084/m9.figshare.33136013

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 18 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1073/pnas.2603853123.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 5 keywords, 11 MeSH terms, 3 funders, 65 references.

Cite

This paper

Guo, X., Liu, M., Xiong, Q., Ngai, H., He, M., Li, X., Zheng, Y., Xu, F., Ma, M., & Wu, R. (2026). A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice. Proceedings of the National Academy of Sciences of the United States of America, 123(34), e2603853123. https://doi.org/10.1073/pnas.2603853123

BibTeX

@article{guo2026nose,
author = {Guo, Xinsong and Liu, Mengyan and Xiong, Qingcheng and Ngai, Howai and He, Mingdong and Li, Xinying and Zheng, Yingwei and Xu, Fuqiang and Ma, Minghong and Wu, Ruiqi},
title = {{A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = aug,
volume = {123},
number = {34},
pages = {e2603853123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2603853123},
url = {https://doi.org/10.1073/pnas.2603853123},
pmid = {42611993},
pmcid = {PMC13506056}
}

RIS

TY - JOUR
AU - Guo, Xinsong
AU - Liu, Mengyan
AU - Xiong, Qingcheng
AU - Ngai, Howai
AU - He, Mingdong
AU - Li, Xinying
AU - Zheng, Yingwei
AU - Xu, Fuqiang
AU - Ma, Minghong
AU - Wu, Ruiqi
TI - A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/08/18
VL - 123
IS - 34
SP - e2603853123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2603853123
UR - https://doi.org/10.1073/pnas.2603853123
LA - en
ER -

CSL-JSON

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"type": "article-journal",
"title": "A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice",
"container-title": "Proceedings of the National Academy of Sciences of the United States of America",
"author": [
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"family": "Guo",
"given": "Xinsong"
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"family": "Liu",
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{
"family": "Xiong",
"given": "Qingcheng"
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{
"family": "Ngai",
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{
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{
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"container-title-short": "Proc Natl Acad Sci U S A",
"volume": "123",
"issue": "34",
"page": "e2603853123",
"DOI": "10.1073/pnas.2603853123",
"PMID": "42611993",
"PMCID": "PMC13506056",
"ISSN": "0027-8424",
"publisher": "National Academy of Sciences",
"URL": "https://doi.org/10.1073/pnas.2603853123",
"language": "en",
"issued": {
"date-parts": [
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