Noise-evoked dopamine dynamics in the nucleus accumbens and tail of the striatum.

Overview

1. Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan

Abstract

Sound is essential for threat detection. In many animals, salient sounds trigger defensive behaviors, suggesting an innate negative valence. Here, we examined how salient noise is represented in dopaminergic circuits encoding valence and saliency. In the nucleus accumbens (NAc), dopamine decreased during noise presentation in all subjects, with a subset additionally showing a transient increase at noise onset. Dopaminergic fibers from the ventral tegmental area showed corresponding patterns in the NAc. In the tail of the striatum (TS), dopamine increased in response to noise, also suggesting negative valence coding. For ramped and damped noises, dopamine dynamics are related to the temporal profile of sound intensity. Neural activity increased in both NAc and TS during noise. Together, these findings suggest that dopaminergic signaling in the NAc and TS represents noise intensity with negative valence, while NAc dopamine also reflects perceived saliency and may contribute to defensive behaviors evoked by auditory stimuli.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Data and code availability

• Data: Data reported in this paper will be shared by the lead contact upon request. • Code: This study did not report original code. • Other data: Any additional information required to reanalyze the data reported in this paper is available from the lead contact.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 3 keywords, 9 funders, 66 references, 3 RRIDs.

Cite

This paper

Furuyama, T., Ono, M., Kato, N., & Yamamoto, R. (2026). Noise-evoked dopamine dynamics in the nucleus accumbens and tail of the striatum. iScience, 29(5), 115789. https://doi.org/10.1016/j.isci.2026.115789

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1016/j.celrep.2026.117298 [code]

Midbrain endocannabinoids actuate dopamine-based action selection.

Journal: Cell reports

In common: cellular / molecular, 7 references

[2] doi:10.1038/s41467-026-73994-1 [code]

Prediction error correlates in the striosome-dopamine circuit emerge from information gain.

Journal: Nature communications

In common: 7 references

[3] doi:10.1111/ejn.70486

Dopamine in the Nucleus Accumbens Signals Salience of Auditory Deviance.

Journal: The European journal of neuroscience

In common: 6 references

[4] doi:10.1038/s42003-026-10485-5 [code]

Dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors.

Journal: Communications biology

In common: 5 references

[5] doi:10.1016/j.isci.2026.117130 [code]

Region-specific weighting of sensory intensity and reward prediction error by dopamine signals.

Journal: iScience

In common: 5 references

[6] doi:10.1038/s41467-026-70519-8 [code]

Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward.

Journal: Nature communications

In common: cellular / molecular, 4 references

[7] doi:10.7554/elife.93664 [code]

Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing.

Journal: eLife

In common: cellular / molecular, 4 references

[8] doi:10.1113/ep094001

Distinct electrophysiology and dopaminergic modulation of medium spiny neurons across divisions of the tail striatum and the dorsolateral striatum.

Journal: Experimental physiology

In common: 4 references

[9] doi:10.1126/sciadv.aee6579 [code]

Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning.

Journal: Science advances

In common: cellular / molecular, 4 references

[10] doi:10.1038/s41467-026-77168-x [code]

Cholinergic-dependent dopamine signals in mouse dorsomedial striatum are regulated by frontal but not sensory cortices.

Journal: Nature communications

In common: 4 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.