The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis.

1. Department of Pediatric Physiology, Innovation & Research Support Center, Graduate School, International University of Health and Welfare, Tokyo, Japan
2. Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan
3. Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
4. Department of Clinical Genetics, Yokohama City University Hospital, Yokohama, Japan
5. Department of Neurogenetics, Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan
6. Advanced Pediatric Medicine, Tohoku University School of Medicine, Miyagi, Japan
7. Department of Reproductive Medicine, Center for Regenerative Medicine, National Center for Child Health and Development (NCCHD), Tokyo, Japan
8. Research Center for Animal Life Science (RCALS), Shiga University of Medical Science, Otsu, Japan
9. Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Japan
10. Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
11. Department of Pediatrics, Nara Medical University, Kashihara, Japan
12. Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan
13. Department of Advanced Medical Technologies, National Cerebral and Cardiovascular Center, Osaka, Japan
14. Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland
15. Department of Ophthalmology, University of Basel, Basel, Switzerland
16. Department of Genetics and Genome Biology, University of Leicester, Leicester, UK
17. Bannu Medical College, MTI Bannu, Bannu, Pakistan
18. Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des aveugles, Lausanne, Switzerland
19. Advanced Molecular Genetics and Genomics Disease Research and Treatment Centre, Dow University of Health Sciences, Karachi, Pakistan
20. University of Groningen, University Medical Center Groningen, Department of Genetics, Nijmegen, the Netherlands
21. Department of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands
22. Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands
23. Medical Genetics Division, Pediatric Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia
24. Center for Genetics and Inherited Diseases, Taibah University, Almadinah Almunwarah, Saudi Arabia
25. Faculty of Applied Medical Sciences, Taibah University, Almadinah Almunwarah, Saudi Arabia
26. Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
27. Department of Pediatric Neurology, Strasbourg University Hospital, Strasbourg, France
28. Laboratoire de Diagnostic Génétique, Institut de Génétique Médicale d'Alsace (IGMA), Hôspitaux Universitaire de Strasbourg, Strasbourg, France
29. IMPaCT-Genómica - Enfermedades Raras, Servei de Genètica, Hospital del Mar, Universitat Pompeu Fabra (UPF), Barcelona, Spain
30. Service de génétique médicale, CHU de Nantes, Nantes, France
31. Institut du thorax, INSERM, CNRS, Nantes Université, Nantes, France
32. Genetic Health Service New Zealand (Northern Hub), Auckland City Hospital, University of Auckland, Auckland, New Zealand
33. Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
34. Department of Pharmacotherapeutics, Shiga University of Medical Science, Otsu, Japan
35. Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
36. Center for Human Brain Resource Initiative (ChBRI), Niigata University, Niigata, Japan
37. Department of Pediatrics, Showa Medical University, Tokyo, Japan
38. Epilepsy Medical Center, Showa Medical University Hospital, Tokyo, Japan
39. Department of Rare Disease Genomics, Yokohama City University Hospital, Yokohama, Japan
40. Medical Genome Center, National Center of Neurology and Psychiatry, Kodaira, Japan

@article{ariyama2026mtor,
author = {Ariyama, Hirotaka and Tsukamura, Atsushi and Miyatake, Satoko and Okado, Satoko and Itabashi, Itsuki and Ogura, Ami and Suzuki, Atsunobu and Kurakawa, Hyuga and Sakaguchi, Yuki and Nakatake, Yuhki and Sanada, Ryunosuke and Terakado, Ichiro and Koshimizu, Eriko and Mizuguchi, Takeshi and Hamada, Keisuke and Ogata, Kazuhiro and Nakagawa, Eiji and Sakakibara, Takafumi and Shirai, Manabu and Fujihara, Yoshitaka and Ullah, Mukhtar and Quinodoz, Mathieu and Rivolta, Carlo and Khan, Abdul Ghafoor and Khan, Muhammad Nadeem and Ansar, Muhammad and Gerkes, Erica H and Rinne, Tuula and Stegmann, Alexander PA and Sinnema, Margje and Alghamdi, Malak Ali and Alharby, Essa and Balahmar, Reham M and Almontashiri, Naif AM and Baer, Sarah and Piton, Amélie and Curià, Carla Díes and Mercier, Sandra and Cogné, Benjamin and Yap, Patrick and Morita, Shin-ya and Kakita, Akiyoshi and Kato, Mitsuhiro and Maruo, Yoshihiro and Matsumoto, Naomichi and Mori, Masaki},
title = {{The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis}},
journal = {iScience},
year = {2026},
month = apr,
volume = {29},
number = {6},
pages = {115860},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.115860},
url = {https://doi.org/10.1016/j.isci.2026.115860},
pmid = {42164854},
pmcid = {PMC13186030}
}

TY - JOUR
AU - Ariyama, Hirotaka
AU - Tsukamura, Atsushi
AU - Miyatake, Satoko
AU - Okado, Satoko
AU - Itabashi, Itsuki
AU - Ogura, Ami
AU - Suzuki, Atsunobu
AU - Kurakawa, Hyuga
AU - Sakaguchi, Yuki
AU - Nakatake, Yuhki
AU - Sanada, Ryunosuke
AU - Terakado, Ichiro
AU - Koshimizu, Eriko
AU - Mizuguchi, Takeshi
AU - Hamada, Keisuke
AU - Ogata, Kazuhiro
AU - Nakagawa, Eiji
AU - Sakakibara, Takafumi
AU - Shirai, Manabu
AU - Fujihara, Yoshitaka
AU - Ullah, Mukhtar
AU - Quinodoz, Mathieu
AU - Rivolta, Carlo
AU - Khan, Abdul Ghafoor
AU - Khan, Muhammad Nadeem
AU - Ansar, Muhammad
AU - Gerkes, Erica H
AU - Rinne, Tuula
AU - Stegmann, Alexander PA
AU - Sinnema, Margje
AU - Alghamdi, Malak Ali
AU - Alharby, Essa
AU - Balahmar, Reham M
AU - Almontashiri, Naif AM
AU - Baer, Sarah
AU - Piton, Amélie
AU - Curià, Carla Díes
AU - Mercier, Sandra
AU - Cogné, Benjamin
AU - Yap, Patrick
AU - Morita, Shin-ya
AU - Kakita, Akiyoshi
AU - Kato, Mitsuhiro
AU - Maruo, Yoshihiro
AU - Matsumoto, Naomichi
AU - Mori, Masaki
TI - The mTOR-Dop1a-Agpat2 axis regulates nuclear phospholipid homeostasis
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/04/22
VL - 29
IS - 6
SP - 115860
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.115860
UR - https://doi.org/10.1016/j.isci.2026.115860
LA - en
ER -

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