Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis.
Overview
and 6 other authors
Vincent Prevot20,21, Alberto Pascual2,3, Rafael Fernández-Chacón2,3,4, Manuel Tena-Sempere7,8,9, Nelly Pitteloud5,6, Eva Gonzalez-Suarez1,1621 affiliations
- Tumor Biology and Immunology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain
- Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain
- Department of Medical Physiology and Biophysics, School of Medicine, University of Seville, 41009 Seville, Spain
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28029 Madrid, Spain
- Service of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital; Lausanne 1011, Switzerland
- Faculty of Biology and Medicine, University of Lausanne; Lausanne 1005, Switzerland
- Instituto Maimónides de Investigación Biomédica de Córdoba/Hospital Universitario Reina Sofia; 14004 Córdoba, Spain
- Department of Cell Biology, Physiology and Immunology, University of Córdoba; 14071 Córdoba, Spain
- CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III; 14004 Córdoba, Spain
- Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
- Grupo Fisiopatología Endocrina, Departamento de Endocrinología, Instituto de Investigación Sanitaria de Santiago de Compostela, Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), 15706 Santiago de Compostela, Spain
- Department of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), 28049 Madrid, Spain
- Department of Pediatrics, Stanford University, Stanford CA 94304, California, United States
- Department of Medicine, Endocrinology, Diabetology, and Metabolism Unit, CHUV; Lausanne 1005, Switzerland
- Departamento de Biología Celular, Facultad de Biología, Universidad de Sevilla, 41009 Seville, Spain
- Oncobell, Bellvitge Biomedical Research Institute, IDIBELL; 08908 Barcelona, Spain
- Laboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute; NW1 1AT London, United Kingdom
- Centre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, E1 4NS London, UK
- Tumor Microenvironment and Immunomodulation Unit, Instituto de Salud Carlos III (ISCIII), 28222 Madrid, Spain
- Lille University, Inserm, CHU Lille, Lille Neuroscience and Cognition, UMR-S 1172, Labex DistAlz, 59000 Lille, France
- Laboratory of Development and Plasticity of the Neuroendocrine Brain, FHU 1000 Days for Health, EGID, 59045 Lille, France
Abstract
The hypothalamic-pituitary-g
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data and to no code of its authors: see the Data section.
Tracing map
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Data
Datasets cited
- geo:GSE169109, at NCBI GEO; found in the text, “Microglia, the main source of Rank in the…”
Data and materials availability
The scRNAseq results obtained in this work have been deposited at GEO, GSE240379. Mouse strains used in this study are subject to a Material Transfer Agreement and can be shared upon reasonable request and in accordance with the corresponding institutional regulations. The rest of the data used in the preparation of the manuscript are available in the main text or in the supplementary material file.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Publisher: n/a → American Association for the Advancement of Science
- Authors: added Beatriz Romero-de la Rosa (0009-0003-0432-247X); removed Beatriz Romero-de la Rosa
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 26 authors, 18 MeSH terms, 10 funders, 99 references.
Cite
This paper
Collado-Sole, A., Borjini, N., Zhai, J., Ruiz-Pino, F., Soria-Alcaide, G., Folgueira, C., García-Vilela, C., la Rosa, B. R.-d., Lopez, V., Zouaghi, Y., Jacobs, A., Mora-Romero, B., Barranco, A., Yoldi, G., Rizzoti, K., Sabio, G., Perez-Chacon, G., Santamaria, P. G., Esteban, J. A., . . . Gonzalez-Suarez, E. (2026). Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-g
BibTeX
@article{colladosole2026
author = {Collado-Sole, Alejandro and Borjini, Nozha and Zhai, Jing and Ruiz-Pino, Francisco and Soria-Alcaide, Gonzalo and Folgueira, Cintia and García-Vilela, Celia and la Rosa, Beatriz Romero-de and Lopez, Victor and Zouaghi, Yassine and Jacobs, An and Mora-Romero, Bella and Barranco, Alexandra and Yoldi, Guillermo and Rizzoti, Karine and Sabio, Guadalupe and Perez-Chacon, Gema and Santamaria, Patricia G and Esteban, Jose Antonio and Journiac, Nathalie and Prevot, Vincent and Pascual, Alberto and Fernández-Chacón, Rafael and Tena-Sempere, Manuel and Pitteloud, Nelly and Gonzalez-Suarez, Eva},
title = {{Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-g
journal = {Science (New York, N.Y.)},
year = {2026},
month = may,
volume = {392},
number = {6800},
pages = {eaeb6999},
publisher = {American Association for the Advancement of Science},
issn = {0036-8075},
doi = {10.1126/
url = {https://
pmid = {41818388},
pmcid = {PMC7619046}
}
RIS
TY - JOUR
AU - Collado-Sole, Alejandro
AU - Borjini, Nozha
AU - Zhai, Jing
AU - Ruiz-Pino, Francisco
AU - Soria-Alcaide, Gonzalo
AU - Folgueira, Cintia
AU - García-Vilela, Celia
AU - la Rosa, Beatriz Romero-de
AU - Lopez, Victor
AU - Zouaghi, Yassine
AU - Jacobs, An
AU - Mora-Romero, Bella
AU - Barranco, Alexandra
AU - Yoldi, Guillermo
AU - Rizzoti, Karine
AU - Sabio, Guadalupe
AU - Perez-Chacon, Gema
AU - Santamaria, Patricia G
AU - Esteban, Jose Antonio
AU - Journiac, Nathalie
AU - Prevot, Vincent
AU - Pascual, Alberto
AU - Fernández-Chacón, Rafael
AU - Tena-Sempere, Manuel
AU - Pitteloud, Nelly
AU - Gonzalez-Suarez, Eva
TI - Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-g
T2 - Science (New York, N.Y.)
J2 - Science
PY - 2026
DA - 2026/
VL - 392
IS - 6800
SP - eaeb6999
SN - 0036-8075
PB - American Association for the Advancement of Science
DO - 10.1126/
UR - https://
LA - en
ER -
CSL-JSON
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