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Sexual identity of Akh neurons shapes Nucb1-dependent metabolic and reproductive plasticity.

Overview

Authors: Narsimha Pujari1, Kamea Chevrier1, Natalie Turriff1, Yona Al-Tahir1, Dipesh Shahi1, Aidin Shaikhei Gorjan1, Alex SO Li1, Shreyas V Jois2, Erika Donà3, Maud Ferrari1, Suraj Unniappan1, Adelaine KW Leung1
ORCID iDs: Erika Donà, Adelaine KW Leung
  1. Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada
  2. Health Sciences, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
  3. Institute of Neuroscience, Consiglio Nazionale delle Ricerche (CNR), Vedano al Lambro, MB 20854, Italy
Institutions: University of Saskatchewan (Canada); National Research Council (Italy)
Journal: iScience, volume 29, issue 6, article 116097
Dates: received 25 October 2025; accepted 8 May 2026; published online 1 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.116097 · PMID 42291196 · PMCID PMC13253106 · OpenAlex W7163080168
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: cellular / molecular (subfield)
Methods: Evoked potentials, Statistics
Keywords: physiology, neuroscience, endocrinology, model organism
Topic: Neurobiology and Insect Physiology Research (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: Canadian Institutes of Health Research (PJT-192046); Canada Foundation for Innovation; National Institutes of Health (P40 OD018537); Natural Sciences and Engineering Research Council of Canada (RGPIN-05383-20); University of Saskatchewan
Citations: not cited yet (Europe PMC); 79 references in the paper
Research resources: α-mouse-GFP RRID:AB_221568, α-mouse IgG-Alexa488 RRID:AB_2534069, α-rat IgG-Alexa488 RRID:AB_2534074, α-rabbit IgG-Alexa594 RRID:AB_2534079, α-mouse-CD8a RRID:AB_467087, D. melanogaster: akh-GAL4 (III) RRID:BDSC_25684, UAS-tra-RNAi (III) RRID:BDSC_28512, UAS-mCD8::gfp RRID:BDSC_32186, TRiP Control (III) RRID:BDSC_36303, TRiP Control (II) RRID:BDSC_36304, UAS-amon-RNAi (II) RRID:BDSC_41635, D. melanogaster: UAS-nucb1-RNAi (II) RRID:BDSC_44019, D. melanogaster: ilp2-GAL4 (III) RRID:BDSC_48030, D. melanogaster: nSyb-GAL4 (III) RRID:BDSC_51941, D. melanogaster: ilp3-GAL4 (II) RRID:BDSC_52660, UAS-slob-RNAi (III) RRID:BDSC_55879, D. melanogaster: ilp5-GAL4 (II) RRID:BDSC_66007, D. melanogaster: UAS-nucb1-RNAi (III) RRID:Flybase_FBst0469982, RStudio 2025.05.0+496 RRID:SCR_000432, Uniprot, Q9VVK7 RRID:SCR_002380, GraphPad Prism v10.4.1 RRID:SCR_002798, ImageJ RRID:SCR_003070, snRNA-seq, Fly Cell Atlas RRID:SCR_005032, Adobe Illustrator RRID:SCR_010279, Biorender RRID:SCR_018361

Abstract

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Code

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Data

Datasets cited

Code and data availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2026.116097.

Versions

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Version 2, 28 September 2026

  • Authors: added Adelaine KW Leung (0000-0002-2849-4474); removed Adelaine KW Leung

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 4 keywords, 5 funders, 78 references, 25 RRIDs.

Cite

This paper

Pujari, N., Chevrier, K., Turriff, N., Al-Tahir, Y., Shahi, D., Gorjan, A. S., Li, A. S., Jois, S. V., Donà, E., Ferrari, M., Unniappan, S., & Leung, A. K. (2026). Sexual identity of Akh neurons shapes Nucb1-dependent metabolic and reproductive plasticity. iScience, 29(6), 116097. https://doi.org/10.1016/j.isci.2026.116097

BibTeX

@article{pujari2026sexual,
author = {Pujari, Narsimha and Chevrier, Kamea and Turriff, Natalie and Al-Tahir, Yona and Shahi, Dipesh and Gorjan, Aidin Shaikhei and Li, Alex SO and Jois, Shreyas V and Donà, Erika and Ferrari, Maud and Unniappan, Suraj and Leung, Adelaine KW},
title = {{Sexual identity of Akh neurons shapes Nucb1-dependent metabolic and reproductive plasticity}},
journal = {iScience},
year = {2026},
month = jun,
volume = {29},
number = {6},
pages = {116097},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.116097},
url = {https://doi.org/10.1016/j.isci.2026.116097},
pmid = {42291196},
pmcid = {PMC13253106}
}

RIS

TY - JOUR
AU - Pujari, Narsimha
AU - Chevrier, Kamea
AU - Turriff, Natalie
AU - Al-Tahir, Yona
AU - Shahi, Dipesh
AU - Gorjan, Aidin Shaikhei
AU - Li, Alex SO
AU - Jois, Shreyas V
AU - Donà, Erika
AU - Ferrari, Maud
AU - Unniappan, Suraj
AU - Leung, Adelaine KW
TI - Sexual identity of Akh neurons shapes Nucb1-dependent metabolic and reproductive plasticity
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/06/01
VL - 29
IS - 6
SP - 116097
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.116097
UR - https://doi.org/10.1016/j.isci.2026.116097
LA - en
ER -

CSL-JSON

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