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Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis.

Overview

Authors: Romane Manceau1,2, Celena M Cherian3, Danie Majeur1,2, Colin J Miller3, Jasper D Fisher3, Frédérick Boisjoly1,2, J Beatrice Liston3, Jennifer A Bako3, Lianna W Wat3, Charlotte F Chao3, Audrey Labarre1,2, Serena Hollman3, Sanjana Prakash3, Sébastien Audet1,2, Lewis Depaauw-Holt1,2, Benjamin Rogers1,2, Anthony Bosson1, Puja Biswas3, Joyce J Y Xi3, Catrina A S Callow3
and 21 other authorsNiyoosha Yoosefi3, Neele Schikora3, Niki Shahraki3, Yi Han Xia3, Alisa Hui4, Jared VanderZwaag5, Khalil Bouyakdan1, Demetra Rodaros1, Pavel Kotchetkov6,7, Caroline Daneault8, Ghazal Fallahpour3, Martine Tetreault1,2, Marie-Ève Tremblay5, Matthieu Ruiz8,9, Baptiste Lacoste6,7,10, J Alex Parker1,2, Ciaran Murphy-Royal1,2, Tao Huan4, Stephanie Fulton1,9, Elizabeth J Rideout3, Thierry Alquier1,11
  1. Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec Canada
  2. Department of Neurosciences, Université de Montréal, Montreal, Quebec Canada
  3. Department of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia Canada
  4. Department of Chemistry, The University of British Columbia, Vancouver, British Columbia Canada
  5. Division of Medical Sciences, University of Victoria, Victoria, British Columbia Canada
  6. Regenerative Medicine and Neuroscience Programs, The Ottawa Hospital Research Institute, Ottawa, Ontario Canada
  7. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario Canada
  8. Montreal Heart Institute Research Centre, Montreal, Quebec Canada
  9. Department of Nutrition, Université de Montréal, Montreal, Quebec Canada
  10. University of Ottawa Brain and Mind Research Institute, University of Ottawa, Ottawa, Ontario Canada
  11. Department of Medicine, Université de Montréal, Montreal, Quebec Canada
Journal: Nature metabolism, volume 8, issue 5, pages 1034-1050
Dates: received 10 September 2024; accepted 5 March 2026; published online 14 April 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s42255-026-01508-w · PMID 41981110 · PMCID PMC13218936 · OpenAlex W4402668655
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials, Connectivity, fMRI & imaging
Keywords: Homeostasis, Glycerides, Hypothalamus, Cellular neuroscience, Metabolism
MeSH: Energy Metabolism*, Homeostasis*, Lipid Droplets*, Neurons*, Animals, Endoplasmic Reticulum, Female, Lipid Metabolism, Male, Mice (* major topic)
Topic: Lipid metabolism and biosynthesis (Biochemistry, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Michael Smith Health Research BC; National Institutes of Health (P40 OD018537, NIH P40OD018537, R01‐GM084947); Canadian Institutes of Health Research; National Institute of General Medical Sciences (GM084947, R01 GM084947, P40OD018537)
Citations: cited by 5 papers (Europe PMC); 76 references in the paper
Research resources: RRID:AB_10000240, RRID:AB_2340355, anti-GFP RRID:AB_2533111, Alexa Fluor 488–goat anti-mouse IgG RRID:AB_2534069, RRID:AB_2534093, Primary antibodies were anti-AGRP RRID:AB_3076273, GT1-7 RRID:CVCL_0281, N46 cells RRID:CVCL_D45, RRID:IMSR_JAX:000664, Male NPY-GFP RRID:IMSR_JAX:006417, POMC-eGFP RRID:IMSR_JAX:009593, RRID:IMSR_JAX:012899, Images were quantified using Fiji RRID:SCR_002285, GraphPad Prism RRID:SCR_002798, A Zeiss fluorescence microscope RRID:SCR_013672, RRID:SCR_016718se

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1038/s42255-026-01508-w.

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s42255-026-01508-w.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 41 authors, 5 keywords, 10 MeSH terms, 4 funders, 74 references, 16 RRIDs.

Cite

This paper

Manceau, R., Cherian, C. M., Majeur, D., Miller, C. J., Fisher, J. D., Boisjoly, F., Liston, J. B., Bako, J. A., Wat, L. W., Chao, C. F., Labarre, A., Hollman, S., Prakash, S., Audet, S., Depaauw-Holt, L., Rogers, B., Bosson, A., Biswas, P., Xi, J. J. Y., . . . Alquier, T. (2026). Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis. Nature metabolism, 8(5), 1034-1050. https://doi.org/10.1038/s42255-026-01508-w

BibTeX

@article{manceau2026neuronal,
author = {Manceau, Romane and Cherian, Celena M and Majeur, Danie and Miller, Colin J and Fisher, Jasper D and Boisjoly, Frédérick and Liston, J Beatrice and Bako, Jennifer A and Wat, Lianna W and Chao, Charlotte F and Labarre, Audrey and Hollman, Serena and Prakash, Sanjana and Audet, Sébastien and Depaauw-Holt, Lewis and Rogers, Benjamin and Bosson, Anthony and Biswas, Puja and Xi, Joyce J Y and Callow, Catrina A S and Yoosefi, Niyoosha and Schikora, Neele and Shahraki, Niki and Xia, Yi Han and Hui, Alisa and VanderZwaag, Jared and Bouyakdan, Khalil and Rodaros, Demetra and Kotchetkov, Pavel and Daneault, Caroline and Fallahpour, Ghazal and Tetreault, Martine and Tremblay, Marie-Ève and Ruiz, Matthieu and Lacoste, Baptiste and Parker, J Alex and Murphy-Royal, Ciaran and Huan, Tao and Fulton, Stephanie and Rideout, Elizabeth J and Alquier, Thierry},
title = {{Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis}},
journal = {Nature metabolism},
year = {2026},
month = apr,
volume = {8},
number = {5},
pages = {1034--1050},
publisher = {Nature Portfolio},
issn = {2522-5812},
doi = {10.1038/s42255-026-01508-w},
url = {https://doi.org/10.1038/s42255-026-01508-w},
pmid = {41981110},
pmcid = {PMC13218936}
}

RIS

TY - JOUR
AU - Manceau, Romane
AU - Cherian, Celena M
AU - Majeur, Danie
AU - Miller, Colin J
AU - Fisher, Jasper D
AU - Boisjoly, Frédérick
AU - Liston, J Beatrice
AU - Bako, Jennifer A
AU - Wat, Lianna W
AU - Chao, Charlotte F
AU - Labarre, Audrey
AU - Hollman, Serena
AU - Prakash, Sanjana
AU - Audet, Sébastien
AU - Depaauw-Holt, Lewis
AU - Rogers, Benjamin
AU - Bosson, Anthony
AU - Biswas, Puja
AU - Xi, Joyce J Y
AU - Callow, Catrina A S
AU - Yoosefi, Niyoosha
AU - Schikora, Neele
AU - Shahraki, Niki
AU - Xia, Yi Han
AU - Hui, Alisa
AU - VanderZwaag, Jared
AU - Bouyakdan, Khalil
AU - Rodaros, Demetra
AU - Kotchetkov, Pavel
AU - Daneault, Caroline
AU - Fallahpour, Ghazal
AU - Tetreault, Martine
AU - Tremblay, Marie-Ève
AU - Ruiz, Matthieu
AU - Lacoste, Baptiste
AU - Parker, J Alex
AU - Murphy-Royal, Ciaran
AU - Huan, Tao
AU - Fulton, Stephanie
AU - Rideout, Elizabeth J
AU - Alquier, Thierry
TI - Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis
T2 - Nature metabolism
J2 - Nat Metab
PY - 2026
DA - 2026/04/14
VL - 8
IS - 5
SP - 1034
EP - 1050
SN - 2522-5812
PB - Nature Portfolio
DO - 10.1038/s42255-026-01508-w
UR - https://doi.org/10.1038/s42255-026-01508-w
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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}
}

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