OSCR

Sleeve gastrectomy improves cognition by enhancing central ERK/CREB/BDNF pathway through increased GIP secretion.

Overview

Authors: Zhaoyinling Wei1, Jingyun Yang1, Yingdan Qiao1, Shuo Wang1, Yuli Cai1, Ling Gao1
ORCID iDs: Yuli Cai, Ling Gao
  1. Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Institutions: Renmin Hospital of Wuhan University (China)
Journal: iScience, volume 29, issue 7, article 116292
Dates: received 20 September 2025; accepted 15 April 2026; published online 12 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.116292 · PMID 42325559 · PMCID PMC13276768 · OpenAlex W7164567047
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, fMRI & imaging
Keywords: therapeutic procedure, molecular interaction, molecular mechanism of behavior
Topic: Bariatric Surgery and Outcomes (Surgery, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82270861); Fundamental Research Funds for the Central Universities (2042020kf1079); Planned International Development Project of Wuhan University (WHU-GJZDZX TS03)
Citations: not cited yet (Europe PMC); 30 references in the paper
Research resources: Anti-ERK1/2 antibody RRID:AB_2758150, Anti-CREB antibody RRID:AB_2758389, Anti-β-actin antibody RRID:AB_2801259, Anti-Phospho-Tau (Ser396) antibody RRID:AB_2834583, Anti-Phospho-ERK1/2 antibody RRID:AB_2863871, RRID:CVCL_0321, C57BL/6J wild-type mice (male, 6 months) RRID:IMSR_JAX:000664, GraphPad Prism (v8.0.1) RRID:SCR_002798, ImageJ (image analysis) RRID:SCR_003070, G∗Power (v3.1; sample size calculation) RRID:SCR_013726, ANY-maze behavioral tracking software RRID:SCR_014014

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

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Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2026.116292.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Yuli Cai (0000-0003-3149-1167); Ling Gao (0000-0003-0714-7200); removed Yuli Cai; Ling Gao

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 3 keywords, 3 funders, 30 references, 11 RRIDs.

Cite

This paper

Wei, Z., Yang, J., Qiao, Y., Wang, S., Cai, Y., & Gao, L. (2026). Sleeve gastrectomy improves cognition by enhancing central ERK/CREB/BDNF pathway through increased GIP secretion. iScience, 29(7), 116292. https://doi.org/10.1016/j.isci.2026.116292

BibTeX

@article{wei2026sleeve,
author = {Wei, Zhaoyinling and Yang, Jingyun and Qiao, Yingdan and Wang, Shuo and Cai, Yuli and Gao, Ling},
title = {{Sleeve gastrectomy improves cognition by enhancing central ERK/CREB/BDNF pathway through increased GIP secretion}},
journal = {iScience},
year = {2026},
month = jun,
volume = {29},
number = {7},
pages = {116292},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.116292},
url = {https://doi.org/10.1016/j.isci.2026.116292},
pmid = {42325559},
pmcid = {PMC13276768}
}

RIS

TY - JOUR
AU - Wei, Zhaoyinling
AU - Yang, Jingyun
AU - Qiao, Yingdan
AU - Wang, Shuo
AU - Cai, Yuli
AU - Gao, Ling
TI - Sleeve gastrectomy improves cognition by enhancing central ERK/CREB/BDNF pathway through increased GIP secretion
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/06/12
VL - 29
IS - 7
SP - 116292
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.116292
UR - https://doi.org/10.1016/j.isci.2026.116292
LA - en
ER -

CSL-JSON

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"author": [
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"container-title-short": "iScience",
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"ISSN": "2589-0042",
"publisher": "Elsevier",
"URL": "https://doi.org/10.1016/j.isci.2026.116292",
"language": "en",
"issued": {
"date-parts": [
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}
}

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