Connexin 50 mediates disease-relevant alpha-synuclein oligomer propagation and neuroinflammation in neurodegenerative disease.
Overview
- Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA
- Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
- Department of Neurobiology, University of Texas Medical Branch, Galveston, TX 77555, USA
Abstract
Connexins, fundamental components of gap junctions and hemichannels, regulate intercellular communication and are emerging neurodegeneration regulators. Primary synucleinopathies and co-morbid synuclein pathologies feature pathological α-synuclein (α-Syn) aggregation, yet mechanisms driving pathogenic α-Syn propagation remain unclear. We identify that connexin 50 (Cx50) interacts with α-Syn aggregates in synucleinopathy-affected
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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Versions
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Version 2, 28 September 2026
- Authors: added Rakez Kayed (0000-0001-6216-8640); removed Rakez Kayed
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 2 keywords, 3 funders, 64 references, 28 RRIDs.
Cite
This paper
Puangmalai, N., Sengupta, U., Bhatt, N., Suthprasertporn, N., Al-Shaebi, F., Shchankin, N., Liew, J. Y., Chatterjee, T., Pansuriya, D., Balci, A. E., Aday, A., Valdebenito-Silva, S., & Kayed, R. (2026). Connexin 50 mediates disease-relevant alpha-synuclein oligomer propagation and neuroinflammation in neurodegenerative disease. iScience, 29(7), 116399. https://
BibTeX
@article{puangmalai2026c
author = {Puangmalai, Nicha and Sengupta, Urmi and Bhatt, Nemil and Suthprasertporn, Nopparat and Al-Shaebi, Fadhl and Shchankin, Nikita and Liew, Jia Yi and Chatterjee, Twisha and Pansuriya, Dhvani and Balci, Ahmet E and Aday, Abbigael and Valdebenito-Silva, Silvana and Kayed, Rakez},
title = {{Connexin 50 mediates disease-relevant alpha-synuclein oligomer propagation and neuroinflammation in neurodegenerative disease}},
journal = {iScience},
year = {2026},
month = jun,
volume = {29},
number = {7},
pages = {116399},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/
url = {https://
pmid = {42369041},
pmcid = {PMC13293656}
}
RIS
TY - JOUR
AU - Puangmalai, Nicha
AU - Sengupta, Urmi
AU - Bhatt, Nemil
AU - Suthprasertporn, Nopparat
AU - Al-Shaebi, Fadhl
AU - Shchankin, Nikita
AU - Liew, Jia Yi
AU - Chatterjee, Twisha
AU - Pansuriya, Dhvani
AU - Balci, Ahmet E
AU - Aday, Abbigael
AU - Valdebenito-Silva, Silvana
AU - Kayed, Rakez
TI - Connexin 50 mediates disease-relevant alpha-synuclein oligomer propagation and neuroinflammation in neurodegenerative disease
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/
VL - 29
IS - 7
SP - 116399
SN - 2589-0042
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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