OSCR

Peripheral inflammation impairs glymphatic function, contributing to neurodegeneration in Alzheimer's disease.

Overview

Authors: Bo Xie1, Jiangru Liu1, Yitong Hao1, Xiaoshu Fu1, Simin Yang2, Chunjie Guo2, Yu Yang1
  1. Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun 130021, China
  2. Department of Radiology, The First Hospital of Jilin University, Jilin University, Changchun 130021, China
Journal: iScience, volume 29, issue 7, article 116581
Dates: received 3 February 2026; accepted 19 May 2026; published online 30 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.116581 · PMID 42491578 · PMCID PMC13378303 · OpenAlex W7166706634
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: structural MRI / diffusion (modality), Alzheimer's / dementia (population), cognitive (subfield)
Methods: Spectral & time-frequency, Connectivity, Statistics, Preprocessing, Graphs, fMRI & imaging
Keywords: Alzheimer’s disease, glymphatic system, peripheral immunity, multimodal MRI, mediation
Topic: Cerebrospinal fluid and hydrocephalus (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Citations: not cited yet (Europe PMC); 68 references in the paper
Research resources: MATLAB RRID:SCR_001622, FreeSurfer RRID:SCR_001847, FSL RRID:SCR_002823, SPM12 RRID:SCR_007037, IBM SPSS Statistics RRID:SCR_016479, Computational Anatomy Toolbox 12 (CAT12) RRID:SCR_019184, MRtrix3 RRID:SCR_024123

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2026.116581.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 5 keywords, 5 funders, 66 references, 7 RRIDs.

Cite

This paper

Xie, B., Liu, J., Hao, Y., Fu, X., Yang, S., Guo, C., & Yang, Y. (2026). Peripheral inflammation impairs glymphatic function, contributing to neurodegeneration in Alzheimer's disease. iScience, 29(7), 116581. https://doi.org/10.1016/j.isci.2026.116581

BibTeX

@article{xie2026peripheral,
author = {Xie, Bo and Liu, Jiangru and Hao, Yitong and Fu, Xiaoshu and Yang, Simin and Guo, Chunjie and Yang, Yu},
title = {{Peripheral inflammation impairs glymphatic function, contributing to neurodegeneration in Alzheimer's disease}},
journal = {iScience},
year = {2026},
month = jun,
volume = {29},
number = {7},
pages = {116581},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.116581},
url = {https://doi.org/10.1016/j.isci.2026.116581},
pmid = {42491578},
pmcid = {PMC13378303}
}

RIS

TY - JOUR
AU - Xie, Bo
AU - Liu, Jiangru
AU - Hao, Yitong
AU - Fu, Xiaoshu
AU - Yang, Simin
AU - Guo, Chunjie
AU - Yang, Yu
TI - Peripheral inflammation impairs glymphatic function, contributing to neurodegeneration in Alzheimer's disease
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/06/30
VL - 29
IS - 7
SP - 116581
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.116581
UR - https://doi.org/10.1016/j.isci.2026.116581
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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