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Intrinsic electrical diversity of PV<sup>+</sup> retinal ganglion cells.

Overview

Authors: Viktória Király1, Günther Zeck1, Paul Werginz1
ORCID iDs: Paul Werginz
  1. Institute of Biomedical Electronics, TU Wien, 1040 Vienna, Vienna, Austria
Institutions: TU Wien (Austria)
Journal: iScience, volume 29, issue 8, article 116842
Dates: received 5 December 2025; accepted 1 July 2026; published online 13 August 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1016/j.isci.2026.116842 · PMID 42631048 · PMCID PMC13495337 · OpenAlex W7202393719
Open access: gold, a free copy (OpenAlex)
Status: code on request
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Single-unit activity, calcium imaging, Connectivity
Keywords: retinal ganglion cells, spike generator, axon initial segment, action potential
Topic: Neuroscience and Neural Engineering (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: FWF
Citations: not cited yet (Europe PMC); 46 references in the paper
Research resources: Neurobiotin ® Tracer RRID:AB_2313575, RRID:AB_2762835, RRID:IMSR_JAX:017320, RRID:IMSR_JAX:024109

Abstract

Mouse retinal ganglion cells (RGCs) transform visual signals into spiking outputs and are known as a heterogeneous cell population. We combined electrophysiological recordings and anatomical analyses to characterize parvalbumin-positive (PV+) RGC subtypes, including ON-OFF direction selective (OODS), ON transient small receptive field (ON tr SmRF), OFF transient medium receptive field (OFF tr MeRF), and the OFF transient small receptive field (OFF tr SmRF) RGC. Intrinsic properties such as input resistance, maximum depolarization rate, and maximum rebound firing rate distinguished five functional subtypes, including one previously unmatched population. Analysis of axonal morphology revealed subtype-specific differences in axon initial segment (AIS) length and diameter. OFF tr MeRF RGCs display shortest AISs and smallest proximal axon diameter, correlating with unique near-threshold spikelets. Following axotomy, loss of the AIS reduced maximum firing rates and altered spike properties. Our results demonstrate substantial biophysical diversity among a subset of PV+ RGCs, complementing previously described differences.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

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Data

No dataset and no data link were found in the paper.

Data and code availability

Data: All data reported in this paper will be shared by the lead contact upon request.

Code: All code used in this study has been deposited at TU Wien Research Data Repository and is publicly available at https://doi.org/10.48436/jmf7t-tek93 as of the date of publication.

Additional information: Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 3, 28 September 2026

  • Authors: added Paul Werginz (0000-0002-3441-3167); removed Paul Werginz

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 4 keywords, 1 funder, 46 references, 4 RRIDs.

Cite

This paper

Király, V., Zeck, G., & Werginz, P. (2026). Intrinsic electrical diversity of PV<sup>+</sup> retinal ganglion cells. iScience, 29(8), 116842. https://doi.org/10.1016/j.isci.2026.116842

BibTeX

@article{kiraly2026intrinsic,
author = {Király, Viktória and Zeck, Günther and Werginz, Paul},
title = {{Intrinsic electrical diversity of PV\<sup\>+\</sup\> retinal ganglion cells}},
journal = {iScience},
year = {2026},
month = aug,
volume = {29},
number = {8},
pages = {116842},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.116842},
url = {https://doi.org/10.1016/j.isci.2026.116842},
pmid = {42631048},
pmcid = {PMC13495337}
}

RIS

TY - JOUR
AU - Király, Viktória
AU - Zeck, Günther
AU - Werginz, Paul
TI - Intrinsic electrical diversity of PV<sup>+</sup> retinal ganglion cells
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/08/13
VL - 29
IS - 8
SP - 116842
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.116842
UR - https://doi.org/10.1016/j.isci.2026.116842
LA - en
ER -

CSL-JSON

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