OSCR

Coincidence of L1 retrotransposition and DNA repair deficiency elicits synthetic lethality in S-phase mature neurons.

Overview

Authors: Fumio Takahashi1,2, Takashi Yamamura1, Shinji Oki1
ORCID iDs: Fumio Takahashi, Shinji Oki
  1. Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan
  2. Research Fellow of Japan Society for the Promotion of Science (JSPS), 5-3-1 Kojimachi, Chiyoda, Tokyo 102-0083, Japan
Institutions: Japan Society for the Promotion of Science (Japan); National Center of Neurology and Psychiatry (Japan)
Journal: iScience, volume 29, issue 9, article 117335
Dates: received 13 November 2025; accepted 10 August 2026; published online 25 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.117335 · PMID 42698704 · PMCID PMC13542511 · OpenAlex W7204177052
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: mouse (organism), other condition (population), Alzheimer's / dementia (population)
Methods: Statistics, Evoked potentials
Keywords: neurodegeneration, Alzheimer’s disease, mouse model, neuronal cell death, LINE-1, retrotransposition, cell cycle, replication stress, Brca1, synthetic lethality
Topic: Neurogenesis and neuroplasticity mechanisms (Developmental Neuroscience, Neuroscience), according to OpenAlex
Funding: JSPS KAKENHI (23KJ2199, 24k18634, 20K07895, 25K10652, 23K24802); National Institute of Neuroscience Intramural Research Grant for Neurological and Psychiatric Disorders (30-5/1-4); Mitsubishi Foundation Research Grants in the Natural Sciences
Citations: not cited yet (Europe PMC); 84 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1016/j.isci.2026.117335.

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Version 2, 28 September 2026

  • Authors: added Fumio Takahashi (0009-0007-6793-4894); Shinji Oki (0000-0002-9007-0701); removed Fumio Takahashi; Shinji Oki

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 10 keywords, 3 funders, 84 references.

Cite

This paper

Takahashi, F., Yamamura, T., & Oki, S. (2026). Coincidence of L1 retrotransposition and DNA repair deficiency elicits synthetic lethality in S-phase mature neurons. iScience, 29(9), 117335. https://doi.org/10.1016/j.isci.2026.117335

BibTeX

@article{takahashi2026coincidence,
author = {Takahashi, Fumio and Yamamura, Takashi and Oki, Shinji},
title = {{Coincidence of L1 retrotransposition and DNA repair deficiency elicits synthetic lethality in S-phase mature neurons}},
journal = {iScience},
year = {2026},
month = aug,
volume = {29},
number = {9},
pages = {117335},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.117335},
url = {https://doi.org/10.1016/j.isci.2026.117335},
pmid = {42698704},
pmcid = {PMC13542511}
}

RIS

TY - JOUR
AU - Takahashi, Fumio
AU - Yamamura, Takashi
AU - Oki, Shinji
TI - Coincidence of L1 retrotransposition and DNA repair deficiency elicits synthetic lethality in S-phase mature neurons
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/08/25
VL - 29
IS - 9
SP - 117335
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.117335
UR - https://doi.org/10.1016/j.isci.2026.117335
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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